Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Gardnerella"”.
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Characterization of putative sialidase genes in Gardnerella vaginalis
Gardnerella vaginalis is a hallmark organism in the dysbiosis bacterial vaginosis (BV) in reproductive age women although its role in this condition is not currently understood. Diversity within G. vaginalis in terms of virulence factors such as sialidase activity, may explain why it is also …
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Induction of metronidazole and clindamycin resistance in gardnerella vaginalis
… opportunistic pathogenic bacteria particularly Gardnerella vaginalis. G. vaginalis is a gram-variable pleomorphic bacterium which under normal conditions is considered to exhibit low virulence. G. vaginalis is the most common bacterial species isolated from patients with BV, and isolated in over …
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Characterization of adherence, cytotoxicity and biofilm formation by Gardnerella vaginalis
… BV cases, the predominant bacterial species is Gardnerella vaginalis. It has been demonstrated that G. vaginalis forms an adherent biofilm on the vaginal epithelium of women with BV. Furthemore, evidence suggests that the high rate of recurrence associated with BV is related to incomplete …
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Characterizing the genotypic and phenotypic diversity of Gardnerella vaginalis from vaginal clinical samples
… is not well characterized, it is understood that Gardnerella vaginalis plays a critical role in BV by initiating the formation of the polymicrobial biofilm that characterizes BV and by degrading protective vaginal mucus through the release of sialidase. Recent evidence suggests that the G. …
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Determination of factors affecting the community structure of Gardnerella spp. in the vaginal microbiome
Gardnerella spp. are a hallmark of bacterial vaginosis – a vaginal dysbiosis characterized by the shift from a lactobacilli dominated vaginal microbiome to a diverse microbiome composed of many aerobic and anerobic bacteria. Gardnerella spp. are diverse both phenotypically and genotypically and …
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Screening for novel compounds produced by Actinobacteria and Gardnerella vaginalis that impact HIV-1 infection
… and the BV-associated bacterium (BVAB) Gardnerella vaginalis (GV) could impact HIV infection. NPs from 23 actinobacteria strains were extracted and tested on pseudovirus (PSV) infection. Ten strains showed a range of anti-viral activity from 50 µg/mL to 25 µg/mL, and the identity of the …
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The effect of bacterial vaginosis on HIV infection
… L. crispatus, are displaced by anaerobes such as Gardnerella spp., consistently isolated from the FRT of BV-positive women. Gardnerella spp. produce a number of important virulence factors such as vaginolysin (VLY) and sialidase and are known to initiate the formation of biofilms and hence, …
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Μικροβίωμα και υπογονιμότητα
… μικροοργανισμών (π.χ., Chlamydia trachomatis, Gardnerella vaginalis), συνδέεται άμεσα με φλεγμονές, χαμηλότερα ποσοστά επιτυχίας στην εξωσωματική γονιμοποίηση (IVF) και αυξημένο κίνδυνο αποτυχίας εμφύτευσης. Επιπλέον, τα δεδομένα δείχνουν ότι το προφίλ του κολπικού μικροβιώματος μπορεί να …
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Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… vaginosis (BV) associated bacteria such as Gardnerella spp. not only increased the risk of HIV acquisition but also reduced the ability of ARVs to protect against infection. Additionally, Lactobacillus crispatus (L. crispatus) was used in this study because it has previously shown to …
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Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… vaginosis (BV) associated bacteria such as Gardnerella spp. not only increased the risk of HIV acquisition but also reduced the ability of ARVs to protect against infection. Additionally, Lactobacillus crispatus (L. crispatus) was used in this study because it has previously shown to …
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The regulation of bacterial virulence by mucin glycans
… epithelial cell killing by the vaginal pathogen Gardnerella vaginalis. Together, these results present a roadmap for the development of mucin-inspired antivirulence materials for various niches. With the rise of clinical antimicrobial resistance, these materials, which treat infections by …
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Diversity of vaginal microbiota associated with bacterial vaginosis and the impact on pregnancy outcomes in HIV-infected and uninfected women.
… crispatus dominant and 145/356 (41%) CST3 - Gardnerella vaginalis dominant. There was a high prevalence of dysbiotic vaginal communities and L. iners was the predominant taxa found in > 90% of the women. When exploring whether the vaginal microbiota is associated with pregnancy outcomes, L. …
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Baboon vaginal microbiota: an overlooked aspect of primate physiology
… in the human vagina, with Actinobacteria (Gardnerella vaginalis) and Proteobacteria present in lower numbers. By contrast, Papio baboons harbored species not only of Firmicutes but also of Fusobacteria, Bacteroidetes and Spirochaetes phyla that are not normally abundant in humans. Moreover, …
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A metagenomic approach to understanding the relationship between the vaginal microbiome and women’s reproductive health
… analysis indicated that Prevotella and Gardnerella species were more abundant in Chinese BV patients by linear discriminant analysis (LDA) effect size (LEfSe). The conclusion was that the sialidase test could separate diseased vaginal microbiomes from non-diseased ones. Prevotella and …
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Επιδημιολογική διερεύνηση λοίμωξης γεννητικού συστήματος από Chlamydia Trachomatis στον Ελλαδικό χώρο την τελευταία τριετία
… μαζί με τα C. trachomatis, το πιο συχνό ήταν η Gardnerella Vaginalis και σε ένα ποσοστό του 43% δεν είχαν ταυτόχρονη λοίμωξη από άλλο ΣΜΝ. Η έγκαιρη διάγνωση, η κατάλληλη θεραπεία και η σωστή ενημέρωση του πληθυσμού είναι καθοριστικής σημασίας για τον περιορισμό εξάπλωσης της λοίμωξης. Η …
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Gene expression patterns of the female genital tract and immunomodulation by Lactobacillus species
… vaginal epithelial (VK2) cells stimulated with Gardnerella vaginalis (ATCC 14018) were tested in vitro, RNA was extracted and used for Affymetrix Genechip whole transcript microarray analysis. This study found that significantly over-expressed genes in CMCs compared to PBMCs were mapped to …
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A study of the genital microbiotas of black South African women and men: associations with human papillomavirus and HIV infections
… the bacterial vaginosis (BV)-associated Gardnerella, Prevotella, Sneathia, and Shuttleworthia. The majority of the women had nonLactobacillus-dominated CVMs. Lactobacilli are recognised as protective against sexually transmitted infections. Among the Lactobacillus species detected in the …
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Tiny Can Be Big: The Contribution of Microbial Extracellular Vesicles to Host-Pathogen Interactions
… of their EVs - Lactobacillus gasseri and Gardnerella vaginalis - representatives of a healthy or dysbiotic microbiome, respectively. Both bacteria were shown to release EVs during their normal growth. The application of the purification step increased our confidence in their cargo. By …
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Characterisation of the HIV inhibitory activity of vaginal lactobacilli isolates from young South African women at high risk of HIV acquisition
… to lactobacilli in the presence or absence of Gardnerella vaginalis ATCC 14018 and Prevotella bivia ATCC 29303, was measured using Luminex. Growth rates, bacterial sizes, adhesion to cervical (Ca Ski) and vaginal epithelial cells (VK2), culture pH changes and D/L-lactate production by the …
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Microbial interactions with epithelial surfaces.
… the growth of several vaginal pathogens such as Gardnerella vaginalis, and Candida albicans, without inhibiting the grown of Lactobacillus crispatus, which is a predominant member of the vaginal normal flora. This finding suggests that GML may be useful as a treatment for vaginal infections such …
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