Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Ganglioside"”.
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MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
… from presynaptic complex, and the other is gangliosides and anti-gangliosides antibodies. We found that snapin could increase current density of voltage-gated calcium channels in an isoform- and splice-variant-selective manner. Notably, the CaV2.1 and CaV2.2 channels are mutually exclusively …
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Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
… disialic acids such as present in the<br/> ganglioside GD3 that is upregulated in certain cancers. Siglec-7 is classified as<br/> an inhibitory receptor as it contains immunoreceptor tyrosine based inhibitory<br/> motifs. It has been shown to inhibit NK cytotoxicity in cellular assays …
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Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain
… extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance the rate of recovery of the neurons from the MDMA-induced effects. To assess this GM1 effect, MDMA (20 mglkg x 4 days), GM1 (40 mgkg), MDMA and GM1 or saline was …
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The role of tubulin in ganglioside-induced ramifications in cultured rat brain microglia
… morphology to an activated, amoeboid shape. Gangliosides, despite their role as microglial activators, induce microglial ramifications. To identify the cytoskeletal components involved in microglial ramification, we stimulated cells with gangliosides in the absence or presence of cytoskeletal …
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Protein engineering of botulinum toxins with enhanced ganglioside binding capacity A biophysical and computational approach
… to target neurons, comprising a low affinity ganglioside interaction followed by a higher affinity interaction with a protein receptor. A deeper understanding of the molecular nature of these interactions will facilitate the generation of modified BoNT proteins with novel characteristics and …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
<p>Gangliosides are acidic glycosphingolipids involved in cell adhesion, proliferation, and modulation of signal transduction pathways. It has been reported that tumor-shed gangliosides influence the activity of immune cells including macrophages, NK cells, and T cells. GD3 synthase (GD3S) is the …
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EFFECT OF DIETARY GLYCOMACROPEPTIDE AND CHOLESTEROL ON CORTICAL GANGLIOSIDE- AND GLYCOPROTEIN-BOUND N-ACETYLNEURAMINIC ACID IN YOUNG RATS
… cholesterol supplementation increase cortical ganglioside and glycoprotein sialic acid and cholesterol in animal models, respectively. Doseresponse studies and those varying both sialic acid and cholesterol intake are lacking. Objective: The purpose of this study was to determine the effects of …
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Development of a high-throughput shotgun-mass spectrometry method for qualitative and quantitative analysis of major mammalian brain gangliosides
… quantitively analyze the major mammalian brain ganglioside classes: GM1, GD1, GT1 and GQ1. As a starting point for the method to be developed, a modified ganglioside extraction method from Svennerholm and Ladisch was used (Svennerholm and Fredman, 1980; Ladisch and Gillard, 1985). The …
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A resonant mirror biosensor approach to understand antibody-antigen interactions in Guillain Barré Syndrome
… antibodies were found to be specific to various gangliosides and ganglioside complexes. It was also found that antibody reactivity to gangliosides is affected by membrane components. The most prevalent (20-30%) immunoglobulin in GBS is anti-GM1 (20-30%), which also binds to the LPS of the PEN …
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Thermodynamic Evidence That Ganglioside-Mediated Insertion Of Botulinum A Into The Cholinergic Nerve Ending May Precede Endocytosis And Acidification: A Langmuir Film Study
… As an alternate technique, DPPC/GT1b or total ganglioside extract (80:20) monolayers of a Langmuir Blodgett (LB) Trough were adapted to be artificial membrane models for toxin insertion studies. We conclude that LB monolayer studies are a promising candidate for BoNT/A membrane insertion …
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Charakterisierung tumor-assoziierter Glykosphingolipide von Tumoren des Gastrointestinaltraktes
… GSL-Expression in HCC. Die Expression der Ganglioside mit terminalen CD75s- und iso CD75s-Strukturen sowie der neutralen GSL Laktosylceramid (LacCer), Globotriaosylceramid (Gb3Cer) und Globotetraosylceramid (Gb4Cer) wurde in 35 HCC- und den zugehörigen benachbarten, normalen …
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Isolierung und strukturelle Charakterisierung von E-Selektin-bindenden Gangliosiden aus humanen Granulozyten
… Die Fraktion mit den als kurzkettig bezeichneten Gangliosiden enthielt hauptsächlich die Ganglioside GM3, IV3Neu5Ac-nLc4,IV6Neu5Ac-nLc4 und VI3Neu5Ac-nLc6. Die weiteren Fraktionen bestanden aus komplexen Gemischen von fukosylierten und nicht-fukosylierten Gangliosiden mit …
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Phenotypic characterisation of human iPSC neuronal models of GM2 gangliosidoses
Gangliosides are crucial components on the outer leaflet of the plasma membrane of many cells, especially neurons. Their functions are broad and varied but their high abundance in neurons leaves these cells especially vulnerable to the effects of their accumulation in ganglioside lysosomal storage …
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The role of complex gangliosides in glial cell biology
Gangliosides are a family of sialic acid-containing glycosphingolipids that are enriched in the nervous system. They are located in the outer leaflet of the plasma membrane within lipid rafts and are thought to be involved in numerous cellular events, including proliferation, differentiation, …
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Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers
… europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharide and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, …
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Identification and characterization of an enterocyte receptor for group A porcine rotavirus
… to cells. During these experiments a crude ganglioside mixture was observed to specifically block rotavirus binding. Enterocyte gangliosides were harvested from susceptible piglets and a polar lipid fraction was isolated by solvent extraction and partitioning. Throughout subsequent …
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Detection of colorectal carcinoma-associated antigens using specific antibodies against human milk oligosaccharides
… were used to detect their homologous haptens as gangliosides in the human colorectal carcinoma cell line SW'lll6. Sialyltetrasaccharide b-ceramide was detected in the monosialylganglioside fraction from human meconium and a total ganglioside fraction from SWlll6 cells on thin layer chromatograms …
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Analysis of nerve terminal dysfunction in autoimmune neuropathy
… to the disialosyl epitopes on GQ1b, GT1a and GD3 gangliosides have been produced. Antibodies to these complex gangliosides are thought to be crucial in the pathogenesis of MFS. These antibodies have recently been shown to produce complement dependent, glial and/or neuronal injury at mouse …
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