Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Gammadelta T cells"”.
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The Role of Gammadelta T Cells and CD8+ Memory T Cells in Vaccinia Viral Infection
… a complex process by diverse populations of cells, that can be harnessed for tumor immunotherapies and vaccinations. Vaccinia virus (VV) is the most studied member of the poxvirus family and is responsible for the successful elimination of smallpox worldwide. It is unique among well-studied …
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An Improved Understanding of Bisphosphonates Through Computational Techniques
… as the ability to inhibit the growth of parasite cells and the ability to stimulate human gammadelta T cells. We have used computational techniques, such as CoMSIA and pharmacophore modeling, together with experimental data, to explain these secondary activities. In addition, this work has led to …
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Experimental and Computational Study of Bisphosphonates Targeting Isoprenoid Biosynthesis Pathway
… have the unexpected property of activating human gammadelta T cells to kill tumor cells. In this work, I used experimental, mainly x-ray crystallography and computational methods to understand the structure activity relationships of these bisphosphonates with their targets, farnesyl diphosphate …
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Applications of Solid State Nuclear Magnetic Resonance Spectroscopy as a Tool for Structure Based Drug Design
… of cancer immunotherapy since they stimulate gammadelta T cells of the immune system, inhibit tumor growth, have anti-parasitic, antibacterial, and herbicidal activity. I have used solid state NMR spectroscopy as a tool to obtain structural information on the binding of inhibitors like …