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Showing 1 to 20 of 28 for “"Gamma-aminobutyric acid (GABA)"”.

  1. Role of gamma-aminobutyric acid (GABA) in hypothalamic nuclear development

    McClellan, Kristy Michelle, author, Tobet, Stuart A., advisorColorado State University. Libraries2008

    … (ARC). The VMN and PVN have a unique pattern of GABA expression in elements surrounding the nuclei, with a void of GABA within the region of the developing nuclei. The ARC, on the other hand, has dense GABAergic immunoreactive elements throughout the nucleus. Because of the expression pattern of …

    colostate Repository record

  2. ΣΥΜΒΟΛΗ ΣΤΗΝ ΕΡΜΗΝΕΙΑ ΤΗΣ ΝΕΥΡΟΓΕΝΟΥΣ ΡΥΘΜΙΣΗΣ ΤΗΣ ΕΓΚΕΦΑΛΙΚΗΣ ΚΥΚΛΟΦΟΡΙΑΣ

    Angelopoulos, Elias, Αγγελόπουλος, ΗλίαςNational and Kapodistrian University of Athens1986

    TO TEST THE HYPOTHESIZED ROLE OF GAMMA-AMINOBUTYRIC ACID (GABA) ON THE CEREBRAL CIRCULATION, WE USED A PRESSURE MICRO-INJECTION SYSTEM TO SIMULTANEOUSLY ADMINISTER VARIOUS CONCENTRATIONS OF GABA AND MEASURE THE TISSUE PO22 USING AN ADJACENT PO2 MICROELECTRODE. GABA INJECTED DIRECTLY INTO THE …

    greece Repository record

  3. The Localization of GABA-Like Immunoreactivity in the Optic Lobe Neuropils and Optic Tracts of the Cockroach Leucophaea Maderae

    Guffey, David

    Gamma aminobutyric acid (GABA) is a prominent neurotransmitter found in both vertebrates and invertebrates. The action of GABA has been accepted to be inhibitory in nature, but recent evidence suggests it is both inhibitory and excitatory, depending upon time of day. The amount of GABA measured in …

    wku-diss Repository record

  4. Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance

    Xie, NaVirginia Tech2022

    … enhanced the toxicity of insecticides targeting gamma-aminobutyric acid (GABA)-gated chloride channels, indicating the potential of insect mAChRs as a target for developing novel insecticides/synergists to control resistant pests. A point mutation (A301S) in the GABA-gated chloride channel …

    vt Repository record

  5. Effect of Zolpidem, Zaleplon, and Ramelton on cognitive functioning after awakening from napping

    RIchard W. ColeThe University of Texas Medical Branch2008

    … they induce sleep by binding to the same gamma-aminobutyric acid (GABA) receptors in the central nervous system. They may be less likely than benzodiazepine medications to disrupt natural sleep rhythm and patterns which may make sleep more restful. Ramelteon (Rozerem) is a new category of …

    utmb Repository record

  6. Systemic administration of putrescine induces GABA-like behaviors in rats

    Feng, F. DavidVirginia Polytechnic Institute and State University1982

    … precursor of the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). Conversion of systemically administered putrescine to GABA in rat neural tissues has been reported. In this thesis, three experiments were conducted to characterize changes in rat behavior after putrescine …

    vt Repository record

  7. Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures

    Donovan, Maria D.University College Cork2015

    … as phenobarbital, display poor efficacy rates. Gamma-aminobutyric acid (GABA)-mediated signalling may promote excitatory neurotransmission in neonates with a birth injury due to intracellular accumulation of chloride. Bumetanide is a potential adjunct treatment for neonatal seizures, which …

    cork Repository record

  8. A Structural and Computational Study of GABAA Receptor Diversity

    Sente, AndrijaUniversity of Cambridge2022

    GABAA receptors (GABAARs) are pentameric ligand-gated ion channels that modulate the activity of neural circuits in response to binding of the neurotransmitter $\gamma$-aminobutyric acid (GABA) or small molecule therapeutics, such as benzodiazepines or general anaesthetics. GABAARs assemble from a …

    cambridge Repository record

  9. The synthesis and pharmacology of gamma-aminobutyric acid receptor mimetics

    McDonald, Jane Anne MargaretCity of London Polytechnic1981

    Gamma-aminobutyric acid (GABA) has been shown to be an important inhibitory neurotransmitter in mammalian central nervous system (CNS). GABA receptors have been previously characterized in mammalian brain using 3H-GABA itself, a potent GABA agonist, 3H-muscimol, and the GABA antagonist, …

    london-metro Repository record

  10. Investigating the protective effects of intestinal GABA[subscript A] receptor activation on an animal model of Multiple Sclerosis

    Kohl, Hannah M

    <p>Gamma aminobutyric acid (GABA) is an inhibitory neurotransmitter, produced by neurons in the central nervous system (CNS) and by some species of intestinal bacteria. GABAA receptors are found not only in the CNS, but also in T cells and within the intestines. Past studies have indicated that …

    eastern-wash Repository record

  11. Effects of GABA on inflammation and intestinal barrier disruption

    Long, Tyrel W.

    … microbiota composition, reducing frequencies of gamma-aminobutyric acid (GABA)-producing bacteria. GABA levels are reduced in the brains and circulation of MS patients. We engineered Lactococcus lactis with extra copies of gadB (glutamic acid decarboxylase) and gadC (glutamate/GABA antiporter) to …

    eastern-wash Repository record

  12. Alcohol alters the expression of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (SNAREs) and spontaneous γ-Aminobutyric Acid (GABA) release...

    Varodayan, Florence Prabha2013

    … We found that alcohol increased gamma-aminobutyric acid (GABA) release via HSF1, but had no effect on glutamatergic synaptic vesicle fusion. Collectively, these data indicate that alcohol induction of HSF1 transcriptional activity triggers a specific coordinated adaptation in …

    columbia-diss Repository record

  13. Nature of Large Vesicle Exocytosis in Pancreatic β-cells: Release of ATP and GABA

    Karanauskaite, JovitaDepartment of Clinical Sciences, Lund University2008

    … cargo. The chief inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is also found in pancreatic β-cells though its role in coordinating processes in the pancreas is unknown. Sub-cellular localization has not been fully resolved too. Electrical measurements of ATP, GABA and 5-HT release …

    lund Repository record

  14. Temporal Changes in the Levels of Gamma-Aminobutyric Acid in the Brain of the Cockroach, Leucophaea Maderae

    Newton, Jonathan

    … the biological clock, and it has been shown that gamma-aminobutyric acid (GABA) plays an important role in the vertebrate circadian system. The importance of GABA in the vertebrate SCN and its presence in the brain of the cockroach made the inhibitory neurotransmitter GABA a prime candidate for …

    wku-diss Repository record

  15. ANALYSIS BY CAPILLARY ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION: FROM SMALL MOLECULES TO WHOLE CELLS

    Massie, TaraWake Forest University2010

    … method was developed for the determination of gamma-aminobutyric acid (GABA) and other important brain biogenic amines and amino acids present in biological samples at low levels. The high efficiency and sensitivity necessary to identify toxicologically relevant changes in neurotransmitter …

    wfu Repository record

  16. GABA as a Putative Neurotransmitter in the Optic Lobes of the Crab HEMIGRAPSUS NUDUS

    Fulenwider, Carol L.

    <p>Gamma-aminobutyric acid ( GABA ) is a widely occurring inhibitory neurotransmitter in vertebrate and invertebrate neural tissue. To explore the role of GABA as a putative neurotransmitter in the optic lobes of the crab <em>Hemigrapsus nudus, </em></p> <p>light microscope autoradiography ( LM ARG …

    loma-linda Repository record

  17. Ultra-high Field MRI Methods for Precise Anatomical and Spectroscopic Measurements in the Brain and Application to Neurological and Neuropsychiatric Diseases

    Alper, Judy2022

    … We also developed a method for detecting gamma-Aminobutyric acid (GABA) with spectroscopic editing, with potential application to MDD. In summary, we have presented significant findings in biomarker detection and a novel method for spectroscopic signal editing of GABA at ultra-high field …

    cuny Repository record

  18. A study of ultra-high field strength structural and spectroscopic MR imaging in dementia with Lewy bodies and Alzheimer’s disease

    McKiernan, ElizabethUniversity of Cambridge2025

    … I also suggest that changes in concentrations of gamma-aminobutyric acid (GABA) and glutamate (the primary inhibitory and excitatory neurotransmitters in the brain) may be related to visual hallucinations and cognitive fluctuations, though these analyses were exploratory and findings tentative. In …

    cambridge Repository record

  19. Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation

    O'Loughlin, Elaine K.University College Cork2015

    … and maternal immune activation (MIA). The kainic acid (KA) model of temporal lobe epilepsy (TLE) was used to induce Ammon’s-horn sclerosis (AHS) and to investigate behavioural and cytoarchitectural changes that occur in the amygdala related to Neuropeptide Y1 receptor expression. Results showed …

    cork Repository record

  20. The Role of Gamma Oscillations and Cortical Inhibition In The Development of Working Memory In Adolescence

    Walker, Christopher P, <p>https://orcid.org/0000-0002-1042-075X</p>2020

    … was to evaluate the role of cortical gamma-band (> 30 Hz) oscillations—which are associated with working memory in adults—for the development of working memory capacity in adolescents, and to identify the extent to which the temporal profile of gamma-aminobutyric acid (GABA)-mediated …

    uthsc Repository record

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