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Showing 1 to 3 of 3 for “"Galunisertib"”.
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Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… treatments of HGSC models with TGFβR1 inhibitor galunisertib (LY) would increase sensitivity to chemotherapy drugs such as doxorubicin (Dox). Using several human and mouse HGSC cell models treated with LY, we observed reversal of EMT and increased Dox sensitivity. We extended these studies to a …
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… target OVA cells. TGF-β inhibition with galunisertib (LY2157299, LY) restored GzmB expression in T cells and enhanced cancer killing in co-culture. Since LY monotherapy has been clinically ineffective, we aimed to identify effective combination treatments. SHP099, a SHP2 inhibitor that …
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Investigating the Role of Indoleamine 2,3-Dioxygenase 1 and Transforming Growth Factor Beta 1 in Rebound Immune Suppression Following Chemotherapy in Osteosarcoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms