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Showing 1 to 20 of 40 for “"Galleria mellonella"”.
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An analysis of the cellular and humoral immune responses of Galleria mellonella larvae
… thesis sought to establish the effects of using Galleria mellonella larvae under different conditions to determine the impact these effects could have on larval survival following infection. A number of abiotic factors known to influence the immune response of insects were assessed including …
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The development of Galleria mellonella as a model to test the toxicity of food additives
… Bombyx mori. A widely used alternative model is Galleria. mellonella larvae. G. mellonella fulfil many of the basic requirements of a useful animal infection model and have many advantages over other invertebrate systems. There are a lot of similarities between the insect and mammalian …
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Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA
… Geraniol was effective in protecting of Galleria. mellonella larva from S. sonnei and AIEC infection. The Galleria mellonella larvae were highly tolerant to geraniol - indicating the great potential of geraniol for future in vivo and clinical studies. In light of previous reports that …
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Transition Metal Complexes of Novel Phenanthroline Derivatives and their Antibacterial Activity
… also studied using the greater wax moth larvae Galleria mellonella. The Cu(II) complexes were the most active towards the Gram-positive bacteria and the increase in lipophilicity, up to a certain point, displayed an increase in antibacterial activity of the ligand and its Cu(II) complex. The …
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Sleepers and Creepers, Colony Polymorphisms in Metarhizium robertsii
… and Mixed by infecting Great Wax Moth larvae (Galleria mellonella) with conidial suspension of M. robertsii. Key genes in the conidiation pathway, such as the methyltransferase MrDIM-2, may be relevant for differentiation between the Sleeper and Creeper/Mixed phenotypes. Expression levels of …
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Epidemiology and comparative analysis of Yersinia in Ireland
… we compared their virulence towards Galleria mellonella larvae (a non-mammalian model of human bacterial infections) with the virulence of highly and mildly pathogenic Y. enterocolitica strains. Surprisingly, virulence of pathogenic and non-pathogenic Y. enterocolitica in Galleria …
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Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia
… in vitro. The insect infection model Galleria mellonella was modified to investigate antibiotic adaptation in vivo.TNFα significantly increased planktonic growth of all three bacteria, and increased biofilm formation by K. pneumoniae. TNFα was also found to significantly increase …
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The effect of active prophage carriage on the virulence of Pseudomonas aeruginosa
… (P 0.0002). Infection experiments using the Galleria mellonella model showed that prophage carriage affected virulence and survival in vivo. The WT strain killed larvae significantly faster than strains carrying prophage (P <0.0001) despite reaching a significantly lower bacterial load than …
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Efecto de la textura del suelo sobre la capacidad de desplazamiento e infectividad en laboratorio de Steinernema sp. aislameinto Licán Ray
… utilizando como hospedero larvas de Galleria mellonella (L.). En los tres ensayos se midió la mortalidad al día 3, 6 y 9 después de la aplicación de los NEP. Todas las concentraciones de NEP provocaron 100% de mortalidad en todos los suelos, excepto en suelo arcilloso, donde se …
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Establishing Sodalis species as a laboratory model of endosymbionts
… and survival in an experimental host – Galleria mellonella. The difficulties in culturing bacterial endosymbionts is highlighted; the ability, with care, to culture S. glossinidius, and the potential to compare to closely-related, free-living species such as Sodalis praecaptivus is vital …
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Role of Bacterial Lipocalin Proteins in Antimicrobial Resistance
… norfloxacin treatment significantly increased Galleria mellonella larva survival upon infection in a BcnAdependent<br/>manner. Together, my findings suggest that vitamin E can be used to increase killing by bactericidal antibiotics through interference with<br/>lipocalin binding.<br/><br/>The …
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Oxidative stress responses in Campylobacter jejuni: the role of the Peroxide Regulator PerR
… defect in growth, motility or virulence in the Galleria mellonella insect model. Analysis of microarray data using perR, fur and fur perR mutants allowed the identification of PerR-repressed genes (e.g. ahpC, katA, trxB). Differential RNA sequencing was used to identify target promoters for …
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Functional Genomic Analysis of Natural Product Biosynthesis and Secretion in Aspergillus fumigatus
… less virulent than either single mutant in the Galleria mellonella virulence model system. Significantly, pes1 was found to be involved in the biosynthesis of the conidial metabolite, fumigaclavine C, as this metabolite was absent in both A. fumigatus �akuB:�pes1 and �pes146645. In parallel …
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Comparative pathogenesis of Yersinia enterocolitica biotypes
… cell line and the alternative infection model Galleria mellonella greater wax moth larvae are the main infection models used to investigate the pathogenic potential of Y. enterocolitica biotypes. A diverse collection of Y. enterocolitica strains was used by which this strains collection is …
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Analysis of resistance nodulation division efflux pumps in Acinetobacter baumannii
… models. Using Caenorhabditis elegans and Galleria mellonella a statistically significant difference was shown in AB030 the extremely drug resistant strain. Investigation of the physiological role of adeFGH pump revealed its expression may be more important to cell metabolism and …
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Analysis of the effect of atorvastatin on the virulence of Fungal Pathogens
… common opportunistic fungal pathogen of humans. Galleria mellonella larvae are an ideal model of infection to quickly and easily evaluate the virulence of a range of human fungal pathogens. Atorvastatin is a member of the statin drug family which are the main therapeutic agents used to decrease …
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The Synthesis of Functionalized Glycosides: Coordination Chemistry, Antiparasitic Activity, Precursors to Conformationally Constrained Macrocyclic Architectures and Photophysical Properties
… potent compounds was also investigated using the Galleria Mellonella model. The use of carbohydrates as scaffolds to synthesize conformationally constrained macrocycles was also explored. To this end, several galactosyl donors were synthesized and their reactivity towards glycosylation with a …
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Hexamerine und Neuropeptide in der postembryonalen Entwicklung der Insekten
… Substanzen im Gehirn der großen Wachsmotte Galleria mellonella durch Screening einer Expressionsbibliothek mit polyklonalen Antiseren identifiziert werden. Dabei wurde das Neuropeptid Corazonin identifiziert. Die vollständige Corazonin-mRNA wurde kloniert und sequenziert. Das …
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Progressing the Synthesis, Coordination Chemistry and Biological Evaluation of Phenanthrolines
… cytotoxicity and antifungal activity using the Galleria mellonella insect model. Healthy G. mellonella larvae appeared to be unaffected by the complexes at concentrations up to 500 μg/cm3. The most active complex, [Mn2(ƞ1ƞ1μ2-oda)(phen)4(H2O)2][Mn2(ƞ1ƞ1μ2-oda)(phen)4(ƞ1-oda)2].4H2O (13), …
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