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Showing 1 to 13 of 13 for “"Galectins"”.
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Effects of galectins and antibodies in HIV infection; Novel Assays
… via host glycan-binding protein, such as galectins. To explore this, we examined the interaction of gp120 (the surface Env protein) with a panel of galectins, by adapting the fluorescent anisotropy (FA) assay to microscale. Galectin-8, a galectin with two carbohydrate recognition domains …
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FROM SERUM TO TISSUE: GALECTIN-BINDING GLYCOFORMS OF SERUM GLYCOPROTEINS AS FUNCTIONAL BIOMARKERS
Galectins are small soluble proteins defined by a conserved sequence motif that forms a defining β-galactoside binding site shared among galectins; adjacent binding sites give each galectin a unique fine specificity for a specific subset of galactose containing glycans. A wealth of data now …
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Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. …
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
… 22% of tumours contained T-cell aggregations. Galectins 1, 3, 4 and 7 were also found in the majority of GBM assayed; immune checkpoints galectin-9 and PD-L1 were found in 100% and 50% of assayed tumours, respectively. The perivascular location of galectin-1 approached significance (p=0.0844), …
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CH-[pi] interactions play a central role in protein recognition of carbohydrates/
… family of carbohydrate-binding proteins known as galectins. In Chapter 1, I review previous knowledge of the forces underlying carbohydrate-binding proteins and the forces they utilize to bind their ligands. In particular, I focus on CH-[pi] interactions and galectins.
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Analyzing Interactions Between Cells And Extracellular Matrix By Atomic Force Microscopy
… adhesion receptors for ECM, mediate the former, galectins, a family of animal lectins, the latter. In the second chapter of this thesis, the contributions of both receptor families to the interactions of epithelial MDCK cells with ECM proteins are presented. It was found that galectins-3 and 9 …
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… of a family of immunomodulatory proteins (galectins) in fibroblasts from rhematoid arthritis patients. Synovial fibroblasts were found to differ significantly from bone marrow and skin fibroblasts with higher expression of galectin-9 and galectin-12 in synovial fibroblasts. Galectin-9 and …
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Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization
… produces N-glycans, the preferred ligand for galectins. In tumor cells, galectins bind glycosylated receptors at the cell surface forming a lattice, that restricts receptor endocytosis and enhances its residency at the plasma membrane. In the first part of my thesis, I report that …
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The design and synthesis of fluorescent peptides and disaccharides for tumour imaging.
… Chapter 2: β-Galactoside targeting of galectin-3 Galectins are a family of intra and extra-cellular proteins which bind specifically to the β-galactoside carbohydrate residues of cellular glycoproteins. Several galectins, but most significantly galectin-3, have been found to mediate important …
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Functional properties of galectin-3. Beyond the sugar binding.
… potential of a few plant products for several galectins. We found that their activity was very weak, hence the search for more potent anti-galectin, perhaps also anti-inflammatory remedies continues.
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Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain
… 2) detailing a novel interaction between galectins and interferon-gamma to accentuate DO expression within the brain, and finally 3) discuss the ability of current anti-depressant desipramine to block these interactions and attenuate DO expression within the brain and periphery as a …
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The Role of Galectin-3 in Pathogen Sensing and Cell Autonomous Defense
… leaflet of the membrane to the host cytosol. Galectins, cytosolic host glycan binding proteins, are then able to recognize the exposed sugars and bind them. Subsequently, host defense proteins including the guanylate binding proteins (GBPs) are recruited to the damaged membrane. I propose that …