Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Galectin-9"”.
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… of a family of immunomodulatory proteins (galectins) in fibroblasts from rhematoid arthritis patients. Synovial fibroblasts were found to differ significantly from bone marrow and skin fibroblasts with higher expression of galectin-9 and galectin-12 in synovial fibroblasts. Galectin-9 and …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
… Although expression of TIM-3 and its ligand galectin-9 has been demonstrated in mast cells, the transcriptional regulation of these molecules has not been well explored. Considering the emerging role of mast cells in host defense, I studied the effect of various cytokines, a TLR agonist or …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
… that out of 59 glioblastoma samples, 58 showed Galectin-1 as commonly secreted protein and galectin-1 was accumulated near T cells which were present around the blood vessels in glioblastoma samples. The galectin-1 secretion was regulated by IFN-ϒ, which might be from activated T cells. Along …
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Tim-3 and Cell Death in Murine Mercury Induced Autoimmunity
… and granulocytes. Tim-3 and its known ligand galectin-9 play a role in the down-regulation of immune responses, including experimental autoimmune encephalomyelitis and autoimmune conjunctivitis. Tim-3-Ig fusion protein, as well as blocking and stimulating anti-Tim-3 antibodies, were employed …
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A study of immune responses during antiviral treatment for hepatitis C virus infection
… Programmed cell death protein – 1 (PD-1) and Galectin-9, on T cells was studied using flow cytometry and demonstrated restoration of T cell phenotype following sustained viral response. Further work established a difference in PD-1 and Galectin 9 expression on CD8+ and CD4+ T cells between …
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
… cells. Mass spectrometry data identified galectin family members in the glioblastoma secretome. ELISA assays confirmed galectin presence in GBM-derived liquid samples; immunofluorescence confirmed their presence in tumour sections, as well as the presence of T-cells, B-cells and …
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The role of T cell Immunoglobulin Mucin domain in Herpes Simplex Virus-induced Behçet’s Disease mouse model
… arthritis compared to controls. Further, Galectin-9 (Gal-9) has been identified as a TIM-3 ligand (L) and the TIM-3-TIM-3L interaction serves as a specific down-regulator of the Th1 immune response. Behçet’s disease (BD) is a chronic, multisystemic inflammatory disorder with arthritic, …