Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"GalNAc"”.
-
Study of Glycan-Mediated Interactions by Photocrosslinking GlcNAc and GalNAc Analogs
… (GlcNAc) and N-acetylgalactosamine (GalNAc) analogs, GlcNDAz and GalNDAz. I will demonstrate the incorporation of GlcNDAz into N-linked glycans using complementary methods and the applications of GlcNDAz in identification of binding partners of two glycan binding proteins, galectin-1 …
-
Functional Significance of Glycoprotein Clearance by the Asialoglycoprotein Receptor and the Mannose/GalNAc-4-SO4 Receptor
… glycoproteins bearing terminal Siaalpha2,6GalNAc as well as ones bearing terminal Gal/ GalNAc and that the Mannose/GalNAc-4-SO4 receptor: MR) is capable of clearing glycoproteins bearing terminal GalNAc-4-SO4. I am taking a genetic approach identifying endogenous ligands for the ASGR and …
-
Expression Of Gal/galnac Lectin Of Entamoeba Histolytica In Transgenic Chloroplasts To Develop A Vaccine For Amebiasis
… and epithelial cells through interaction of Gal/GalNAc lectin, an amebic surface adhesin with the host glycoconjugates. The parasite then secrets the proteolytic enzymes that disrupt the intestinal mucus and epithelial barrier facilitating tissue penetration. The trophozoite then kills the host …
-
Investigations into the Functional Significance and Plasticity of O-linked Glycosylation
… by the attachment of an N-acetylgalactosamine (GalNAc) to a serine or threonine. This forms an initial structure called Thomsen-nouvelle (Tn) antigen. In healthy tissue, the Tn antigen is cryptic and further elaborated into linear or branched glycans. Failure in O-GalNAc glycan extension results …
-
Investigating asparagine-linked protein glycosylation in eukaryotic and prokaryotic systems
… heptasaccharide donor has been characterized as GalNAc-al,4- GalNAc-al,4-(Glcpl1,3)-GalNAc-al,4-GalNAc-al,4-GalNAc-al,3-Bac-al ,PP-Und, where Bac is bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose). A synthetic route was developed to access bacillosamine-phosphate, which was incorporated …
-
Molecular characterization of soybean meal trypsin inhibitors and lectins as a basis for developing approaches to mitigate their anti-nutritional effects
… cells containing N-acetyl galactosamine (GalNAc) to impede nutrient uptake into the blood. Soybean needs to be processed to get rid of these anti-nutrients before human or animal consumption. The conventional method of soybean processing which involves the moist heat treatment of soybeans …
-
Reconocimiento Molecular de Análogos de Antígenos Tn como Base para el Diseño de Vacunas Terapéuticas contra el Cáncer
… el primer carbohidrato la N-acetilgalactosamina (GalNAc). En las células tumorales se producen cambios importantes en los patrones de glicosilación de la MUC1, lo cual va asociado a la exposición de determinados antígenos que se encuentran enmascarados en las moléculas presentes en las células …
-
New insights into molecular recognition of epitopes related to MUC1 human mucin by lectins
Tn antigen ( -O-GalNAc-Ser/Thr) is one of the most specific human tumorassociated structures. This motif is implicated in HIV infection and it is expressed early in tumor cells. It has been observed that there is a direct correlation between carcinoma aggressiveness and the density of this antigen. …
-
IMPACT OF ACLY GENE SILENCING ON HEPATIC LIPID METABOLISM
… iniezioni intraperitoneali di siRNA coniugati a GalNAc, rispettivamente un siRNA di controllo negativo (GalNAc-siCtrl) e un siRNA diretto contro ACLY (GalNAc-siACLY). Gli animali sono stati mantenuti per 18 settimane in regime di dieta ad alto contenuto di colesterolo (WTD) al fine di indurre …
-
O antigen biosynthesis in Gram-negative bacteria: Characterization of alpha1,4-glucosyltransferase WclY from Escherichia coli O117 and development of glycosyltransferase inhibitors.
… found in the O antigen of E. coli O117 [D-GalNAcβ1-3-L-Rhaα1-4-D-Glcα1-4-D-Galβ1-3-D-GalNAc]n is replaced by N-acetylglucosamine (GlcNAc) in the O antigen of E. coli O107 (GalNAc is N-acetylgalactosamine, Rha is Rhamnose, Gal is galactose). The glycosyltransferases that create the …
-
The role of complex gangliosides in glial cell biology
… channels at juxtaparanode was retarded in GalNAc T -/- mice lacking all complex gangliosides, suggesting that complex gangliosides modulate the formation of nodes of Ranvier. In addition, GalNAc T -/- mice had significantly lower numbers of NG2 positive early oligodendrocyte progenitors …
-
Affinity purification of blood group A-active glycolipids on immobilized Helix pomatia lectin
… aqueous solution. Since N-acetylgalactosamine (GalNAc) is commonly found in glycolipids, three GalNAc-specific lectins were selected to develop a lectin affinity chromatographic method for glycolipids. To circumvent the difficulty of working with micelles, the autoradiographic detection of …
-
Investigations into altered cellular glycosylation associated with metastatic competence in breast cancer cell lines
… pomatia, recognises glycans terminating in α-GalNAc, and is associated with aggressive biological behaviour, poor patient prognosis and metastasis in breast and other cancers. Three breast cancer cell lines characterised to stably synthesise an array of GalNAc-glycans were employed in the work …
-
Ring-Opening of Aziridine -2 -Carboxamides by Carbohydrate C1-O Nucleophiles. Stereoselective Preparation of O-Linked Glycopeptides
… glycopeptides. The synthesis of the alpha-GalNAc-Ser class of glycopeptides is emphasized and either the alpha- or beta-glycoside can be accessed by judicious selection of solvent and metal counter-ion, even in the presence of the native carbohydrate C2-NHAc group. Other classes of …
-
Structure-based design of glycopeptides featuring unnatural tn antigens and their applications to cancer vaccination and diagnosis
… como una unidad de N-acetilgalactosamina (GalNAc) conectada mediante un enlace -O-glicosídico a un aminoácido, ya sea una serina (Ser) o una treonina (Thr), sin ningún tipo de distinción entre las mismas. Sin embargo, ambos derivados presentan diferencias en la orientación del carbohidrato …
-
Cartilage mechanobiology : the effects of loading on the fine structure and function of chondroitin sulfate glycosaminoglycans
… two genes of interest: chondroitin sulfate and GalNAc 4S,6-sulfotransferase.
-
DEVELOPMENT AND CHARACTERIZATION OF NOVEL MONOCLONAL ANTIBODIES TARGETING CARBOHYDRATE ANTIGENS IN CANCER
… anti-GlcNAc (N-Acetyl-D-Glucosamine) and anti-GalNAc (N-Acetyl-D-Galactosamine) mAbs capable of binding to TA3-Ha murine adenocarcinoma. These novel mAbs open a gateway to understanding alternative targeting of cancer cells and expand opportunities in immunotherapy and theranostics.
-
Structure-based design of unnatural glycopeptides for cancer diagnosis and therapy
… contiene (4S)-4-fluoro-L-prolina y α-S-GalNAc-Thr en posiciones clave de la secuencia y está unido de forma específica a la proteína CRM197. El método de conjugación implica la reducción selectiva y el reensamblaje de uno de los puentes disulfuro en la proteína, permitiendo la unión de …
-
RNA Therapeutics for Fibrolamellar Hepatocellular Carcinoma
… The majority of these use a carbohydrate group, GalNAc, that binds to the asialoglycoprotein receptor (ASGR), allowing targeted delivery to hepatocytes. I hypothesized that ASGR might still be sufficiently expressed in FLC tumors to deliver siRNAs to cells in vivo. I demonstrated that indeed ASGR …
-
SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES
… three-component vaccine containing the GalNAc-O-Thr (Tn) tumor specific antigen, a 20 amino acid helper T-cell epitope (YAF) derived from an outer membrane protein of Neisseria meningitides and a Rha moiety. Synthesis of the vaccine was achieved by automated Fmoc-based solid phase …
Page 1 of 2