Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 235 for “"Gag"”.
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GAG inhibition of collagen-platelet interaction
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 1977
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Viscoelastic characterization of collagen-GAG scaffolds
… performed to determine whether or not collagen-GAG scaffolds exhibit linear viscoelastic behavior. Tension tests were performed on dry and hydrated engineered collagen-GAG scaffolds in order to develop a stress-strain curve. Strains that fell in the linear elastic region of these curves were …
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Molecular electromechanics : modeling electrostatic forces between GAG molecules
Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2001.
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Study of vapor induced crosslinking in collagen/GAG foams
Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1983.
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Nerve regeneration induced by collagen-GAG matrix in collagen
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1994.
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Untersuchungen zum Gag- und Pol-Protein des Prototypischen Foamyvirus (PFV)
… der Foamyviren, die ungewöhnliche Struktur des Gag-Proteins und die Gag unabhängige Pol-Expression, in ihrer Auswirkung auf Morphogenese und Zusammensetzung foamyviraler Partikel untersucht. Für die Morphogenese infektiöser Partikel sind sehr unterschiedliche Mengen der Genprodukte eines …
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Potential commercialization of a collagen-GAG scaffold for liver regeneration
… a profitable business plan based on the collagen-GAG scaffolds. A manufacturing and product sales business model was chosen due to the fairly low level of market competition and moderate barrier to entry. The intellectual property landscape is described and analyzed in terms of problematic …
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A collagen-GAG matrix for the growth of intervertebral disc tissue
Intervertebral disc (IVD) degeneration and herniation is a significant problem, more so in the aviation field. The IVD also changes during spaceflight. Current treatments for IVD problems can have unfavorable long-term consequences. This thesis investigated a porous, biodegradable …
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Physical analysis of collagen-GAG composite scaffolds for nucleus pulposus tissue regeneration
In this study biomaterial scaffolds for regeneration of nucleus pulposus were developed by freeze drying slurries with different proportions of collagen II (CII), chondroitin-6-sulfate (CS), and hyaluronic acid (HA). The scaffolds were analyzed using biochemical assays to determine final …
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Uniaxially aligned, porous collagen-GAG scaffolds for in vitro modeling of trabecular meshwork
… primarily of collagen and glycosaminoglycan (GAG). Many groups have been studying TM cells in vitro to examine their gene expression and response to drugs. However, most in vitro studies of TM cells are likely over-simplified since there is a significant difference between the planar surfaces …
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Control of covalent and non-covalent presentation of biomolecules within collagen GAG scaffolds
Mass transport continues to be a major bottleneck in the development of biomaterials. The diffusive limitation of biomaterials restricts cell viability to regions where nutrients are readily available. To overcome this transport limitation, angiogenic biomaterials that utilize biomolecular cues …
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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag
… candidate vaccines expressing HIV-1C mosaic Gag (GagM) in a proof of concept study. Gag was chosen as the most appropriate target for a T cell-based vaccine as there are many studies correlating control of HIV viral load with T cell responses to Gag. The immunogen was designed by Fischer et …
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Molecular mechanics of cartilage : quantification of GAG electrostatic interactions via high-resolution force spectroscopy
… between negatively charged glycosaminoglycan (CS-GAG) macromolecules are a major determinant of cartilage biomechanical properties. It is thought that the electrostatic component of the total intermolecular interaction is responsible for 50-75% of the equilibrium elastic modulus of cartilage in …
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A Biophysical Investigation of HIV-1 Envelope Cytoplasmic-Tail Mediated Retention in the Gag Lattice
… envelope glycoprotein, Envelope (Env), into Gag lattice assembly sites on the host-cell plasma membrane during virus biogenesis. The mechanistic nature of interaction between Gag, the structural protein, and Env, the viral spike, are dependent on the Gag matrix (MA) and Env cytoplasmic tail …
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In vitro pharmacological inhibition of myofibroblast differentiation and force generation in a collagen-GAG matrix
Induced regeneration studies from three organs in the adult mammal (skin, peripheral nerves, and the conjunctiva) suggest an antagonistic relationship between myofibroblast-mediated contraction of wounds and induced regeneration. In each instance of induced regeneration, contraction blocking was …
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An investigation into cellular attachment and contraction in collagen-GAG scaffolds with characterized pore sizes
… available surface area in a lyophilized Collagen-GAG scaffold on the infiltration and attachment of dermal fibroblasts. An updated design of the Cell Force Monitor (CFM) was used to quantify bulk cellular contractile behavior in seeded scaffolds. The effect of scaffold geometry on fibroblast …
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Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles
… the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). Furthermore, an attempt was made to produce VLP analogues to the HIV-IA …
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Untersuchungen zu Auswirkungen von GAG-Linkeropathien auf die ECM-Homöstase durch die Generierung von knockout-Modellen in Dermalfibroblasten
… die kovalente Bindung von Glykosaminoglykanen (GAG) an ihre core-Proteine gebildet. Der Tetrasaccharid-Linker bildet das Bindeglied zwischen dem core-Protein des PGs und der repetitiven Disaccharidkette des GAGs und wird von vier Glykosyltransferasen synthetisiert. Im initialen, …
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Design and characterization of an aligned collagen-GAG scaffold-membrane composite with soluble factor presentation for tendon tissue engineering
With over 32 million tendon and ligament injuries in the US each year with associated costs of $30 billion, the need for viable tendon repair strategies is becoming increasingly important. Current surgical and tissue engineering approaches have had limited success; repeat injuries and generally …
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