Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Gab1"”.
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Das Adapterprotein Gab1 in der Regulation der IL-6 Signaltransduktion
… pathways are initiated. One of these adapters is Gab1. It is ubiquitously expressed and mediates the activation of the MAPK and PI3K signaling pathways after stimulation with growth factors and cytokines. It was described that Gab1 is involved in the IL-6 mediated ERK-activation. However, the …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 und des feedback-Inhibitors SOCS3 in der IL-6-Signaltransduktion
… Grb2 which links SHP2 to the signal enhancer Gab1. Interestingly, experiments with SHP2 mutants displaying dysregulated phosphatase activity all resulted in a loss of Erk activation. Furthermore, it could be shown that the activation of the Ras/Raf/Erk cascade in SHP2(Ex3-/-) cells is likely …
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Quantitative mass spectrometry analysis of the early signaling dynamics of the epidermal growth factor receptor
… for distinct recruitment mechanisms for Shc and Gab1. Inhibition of phosphatase activity in the system shows unexpected behaviors in the form of specific phosphatase activity against sites on EGFR and Gab1 and ligand-independent activation of ERK. Examination of the data suggests a connection …
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Funktionelle Untersuchungen zum PTPN11-Genprodukt SHP2 und zu PTPN11 Mutanten, die dem Noonan-Syndrom zugrunde liegen
… Phosphotyrosin-Motiv von Signalpartnern (z.B. Gab1) und lässt die Phosphatase-Domäne frei und aktiv. Alle bisher gefundenen Mutationen in PTPN11 verhindern die Bindung zwischen N-SH2 und PTP, was zu einer Überaktivität der Phosphatase führt.Im Rahmen der vorliegenden Arbeit sollten drei Aspekte …
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Genome-wide association study of muscle traits in Icelandic sheep
… ADAM17, GADD45B, GRID2, SPG11, DAB2, FREM3, GAB1, KLF13, AKAP6, PNN, DOCK1 og TRRAP. GADD45B hefur virkni sem tengist stjórnun á vexti og frumudauða. Það var raðgreint í 11 sýnum, sýnin voru borin saman og borin við genið í viðmiðunarerfðamengi sauðfjár en enginn breytileiki sem hefur áhrif á …
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Regulation of hepatocyte growth factor receptor endocytic trafficking
… Recruitment of the adaptor protein Grb2, but not Gab1, was essential for ligand induced HGFR internalization. I then showed Cbl, an E3 ubiquitin ligase recruited by Grb2 to HGFR, played an essential role in receptor internalization. Furthermore, the E3 ligase activity of Cbl and ubiquitination …
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Matriptase Mediated C-Met Signaling In Breast Cancer
… activation of c-Met and the downstream targets Gab1 and Akt. In contrast, matriptase ablation led to a greatly reduced level of c-Met pathway activation. Parallel experiments using RNA silencing of matriptase in four different human breast cancer cell lines similarly demonstrated abrogation of …
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Funktionelle Charakterisierung von Daughter of Sevenless
… die Insulin-Rezeptor-Substrat (IRS) Proteine, Gab1 und Gab2 gerechnet. In dieser Arbeit wurde ein monoklonaler Maus anti-Dos Antikörper etabliert. Das Epitop dieses Antikörpers liegt im Bereich der C-terminalen 416 Aminosäuren des Dos Proteins. Mittels Westernblot Analysen wurde für Dos ein …
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Biochemical And Structural Characterization Of The Core Subunits Of Gpi Transamidase
… signal sequence. Gpi8, Gaa1, Gpi16, Gpi17 and Gab1 are the five known subunits that may encompass the fungal GPI-T; Gpi8 is the catalytic subunit, but the functions of the other subunits remain essentially unknown. In humans, different GPI-T subunits are upregulated in different cancers, making …