Global ETD Search
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Showing 1 to 5 of 5 for “"GYY4137"”.
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Development of Polymeric Microparticle-Based Drug Delivery System for Sustained Delivery of H2S for Treatment of Glaucoma
… nonahydrate (Na2S·9H2O) (a model H2S donor) and GYY4137 were prepared using a non-aqueous coacervation method. Initial preparation attempts using coacervation solvent-evaporation resulted in overheating, uncontrolled solvent evaporation, polymer aggregation, and poor reproducibility. To overcome …
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UNVEILING NOVEL CARDIOPROTECTIVE EFFECTS OF GYY4137, A SLOW-RELEASING HYDROGEN SULFIDE DONOR, AND THEIR RELATIONSHIP TO NEUROHORMONAL MODULATION AND MICRORNA PROFILES DURING MYOCARDIAL ISCHEMIC INJURY.
… of slow-releasing water-soluble H2S donor GYY4137 (GYY) and their relationship to neurohormonal modulation and microRNA profiles during myocardial ischemic injury. In this study, it was found that treatment with GYY (100mg/kg/48hrs) significantly provided preservation of left ventricular …
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The protective role of hydrogen sulfide from obesity-associated metabolic stress in GLP-1 regulation
… in reactive oxygen species (ROS). The H2S donor GYY4137 partially blocked PA- ROS induction. In mice, PA-enriched Western diet (WD) elevated body weight in both sexes and elevated fasting blood glucose and lipid peroxidation in males. A single GYY4137 injection improved oral glucose tolerance in …
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Hydrogen Sulfide (H2S) and the Cardiovascular System
… this respect, slow releasing H2S donors, such as GYY4137, have played a part in elucidating the complex roles of this gas in the body and are also beginning to show promise as possible therapeutics in inflammation - an area in which the function of H2S remains ambiguous. -- This thesis attempts to …