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Showing 1 to 20 of 28 for “"GWA"”.
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Genome-Wide Association Analysis of Major Depressive Disorder and Its Related Phenotypes.
… Recently several genome-wide association (GWA) studies of MDD have been reported; however, few GWA studies focus on the analysis for MDD related phenotypes such as neuroticism and age at onset of MDD. The purpose of this study is to determine risk factors for MDD, identify genome-wide …
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Network-based approach for post genome-wide association study analysis in admixed populations
… some existing pathway-based approaches for GWA study analyses, by exploring different implemented methods for combining effects of multiple modest genetic variants at gene and pathway levels. We then propose a graph-based method, ancGWAS, that incorporates the signal from GWA study, and the …
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Genomic Prediction and Genetic Dissection of Yield-Related Traits in Soft Red Winter Wheat
In multiple species, genome-wide association (GWA) studies have become an increasingly prevalent method of identifying the quantitative trait loci (QTLs) that underlie complex traits. Despite this, relatively few GWA analyses using high-density genomic markers have been carried out on highly …
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The Investigation of the HLA System and Wheat Gluten in Determining Risk of Schizophrenia
Genome-wide association (GWA) studies confirmed that the HLA genes were<br/>strongly associated with schizophrenia but the HLA variants identified by GWA<br/>studies had a lower frequency in patients with schizophrenia than control subjects. The HLA molecules have function of presenting peptide …
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A Genome Wide Association Study for Fusarium Head Blight Resistance in Southern Soft Red Winter Wheat
… resistance loci using a genome wide association (GWA) approach. From 2014-2017, 360 SRWW breeding lines were evaluated in inoculated misted FHB nurseries in Fayetteville and Newport, AR and Winnsboro, LA (2017 only) in a randomized complete block design. At all locations, lines were sown in two …
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Applications and Analysis of NLP Deep Learning Models for Antibiotic's Side Effects Classifications
… and higher-dimensional generalizations of the GWA in the hopes of achieving more accurate dissimilarity-based clustering. I think these methods combined with dimensionality reduction have the potential to further enhance clustering results. In addition, the introduction of the vectorization …
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Electronic and Optical Properties of Silicon Based Semiconductors With Reduced Dimension: A Theoretical Study
… Wannier formula with envelope functions, and GWA formula in symmetrized plane-wave basis. The formulas are successfully applied to the studied materials. Moreover, the methods can be used to study other nano-materials.
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Genome-wide Genotype Imputation-Aspects of Quality, Performance and Practical Implementation
… markers allowing genome wide association (GWA) studies and meta-analysis. Hundreds of such analyses were performed in the last decades. Even though several tools for such analyses are available, an efficient SNP-data transformation tool was tool was necessary. We developed a data management …
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Dissecting key biomass and adaptation traits of Miscanthus through genetic mapping, exploring mechanisms of cold tolerance, and flowering time in Miscanthus and Saccharum
… autumn. From genome-wide association analyses (GWA) of the germplasm panel study, we detected 73 marker-trait associations for overwintering ability. We found that Korea/N China M. sinensis genetic group could be a valuable gene pool for cold tolerance. The M. sinensis Yangtze-Qinling, Southern …
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Gene By Bmi Interactions Influencing C-Reactive Protein Levels In European-Americans
… risk. Multiple Genome-Wide Association Studies (GWAS) have identified a number of genetic polymorphisms which influence CRP levels. SNPs implicated in such studies have been found in or near genes of interest including: CRP, APOE, APOC, IL-6, HNF1A, LEPR, and GCKR. A strong positive correlation …
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Identification of genetic loci underlying equine metabolic syndrome and laminitis risk
… the genome. Genome wide association analyses (GWA) use SNP genotype data to identify those key regions of the genome that are associated with a trait. The objectives of chapter 3 were to (i) perform within breed GWA to identify significant contributing loci in Welsh ponies and Morgans, and (ii) …
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Study of the organic content and mineralogy effects on the acoustic properties of the Niobrara Formation, Denver Basin
… intervals across the Greater Wattenberg Area (GWA). The Niobrara carbonate system in the Denver Basin contains a TOC range of 1-8 wt.%. Additionally, GWA is associated with a geothermal anomaly. This study investigates the effects of TOC, clay content and kerogen maturity levels on the acoustic …
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Spousal Concordance in Academic Achievements and Intelligence and Family-Based Association Studies Identified Novel Loci Associated with Intelligence.
… performed a low density genome-wide association (GWA) analysis with a family-based association test to identify genetic variants that associated with intelligence as measured by WAIS full-score IQ (FSIQ). NTM at 11q25 (rs411280, p=0.000764) and NR3C2 at 4q31.23 (rs3846329, p=0.000675) were 2 novel …
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Genetic characterization of a dominant susceptible Rpp1 allele and analysis of quantitative resistance to Asian soybean rust
… describes using genome-wide association (GWA) mapping to identify potential loci for soybean quantitative resistance to ASR. The phenotypic data was leaf disease severity scores from approximately 2,000 USDA soybean germplasm accessions in response to a mixture of four P. pachyrhizi …
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Primary biliary cholangitis: genetic risk, phenotypic stratification and disease pathogenesis
… intervention. Several genome wide association (GWA) studies have therefore been undertaken, which have successfully identified more than sixty risk loci for the disease. Candidate variants and genes have been proposed at these risk loci. However, there are limitations in interpreting these …
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Integrating bioinformatics and physiology to describe genetic effects in complex polygenic diseases
… Consortium (WTCCC) genome-wide association (GWA) studies with genome-wide expression profiling in pancreas, adipose tissue, liver, and skeletal muscle in patients with or without T2DM or animal models thereof to identify novel T2DM susceptibility loci. We identified 453 single nucleotide …
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Polygenic association in ADHD for the prediction of cognitive performance
… be achievable using currently available ADHD GWA samples. The study also demonstrates the effectiveness of case/pseudo-control imputation for dealing with major allele over-transmission bias, as well as suggesting a number of methodological improvements and directions for future polygenic …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
… however, twin and genome-wide association (GWA) studies clearly indicate that SLE has a strong genetic component. Most recently, Copy Number Variations (CNVs) have been shown to be ubiquitously present in unrelated healthy subjects and contribute substantially to phenotypic variation in the …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
… however, twin and genome-wide association (GWA) studies clearly indicate that SLE has a strong genetic component. Most recently, Copy Number Variations (CNVs) have been shown to be ubiquitously present in unrelated healthy subjects and contribute substantially to phenotypic variation in the …
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Implementation of family-integrated neonatal care by healthcare providers in a district hospital of Limpopo province
… ya tlhokomelo ya masea a sa tšwago go belegwa ye e kopanetšwego le malapa ka tshepedišo ya nyakišišo ya tiro ya tirišano le bakgathatema ba bookelo. Tlhamo wa nyakišišo ya tiro ya go rarolla mathata ya medikologo ye meraro e ile ya hlahla phethagatšo ya tlhokomelo ya masea a sa tšwago go …
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