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Showing 1 to 20 of 41 for “"GVHD"”.

  1. Über den Einfluß von HLA-DPB1-Histoinkompatibilitäten auf die GvHD-Inzidenz nach Knochenmarktransplantationen

    Wisniewski, Ursula

    … der HLA-Merkmale A, B und DR auf die GvHD-Inzidenz nach Knochenmarkstransplantationen in einer Reihe von Untersuchungen nachgewiesen werden konnte, ist ein möglicher Einfluß von DPB1-Inkompatibilitäten bislang nicht geklärt. <br>Da für MHC-DP-Merkmale in vitro und in vivo Funktionen …

    freiburg-diss Repository record

  2. Pathogenesis of Dry Eye in Graft Versus Host Disease (GVHD): Role of Ocular Mucins and Conjunctival Fibrosis

    Shamloo, Kiumars

    … major side effect i.e Graft vs. Host Disease (GVHD). GVHD is a complex, multi-organ disease resulting from an immunological attack by donor engrafted immune cells to host organs, including the eye surface. Mostly based on the time of disease onset after transplantation, GVHD is divided into the …

    chapman Repository record

  3. Bilirubin Nanoparticle As An Anti-Inflammatory Therapy For Graft Versus Host Disease

    Pareek, Sumedha, <p>https://orcid.org/0000-0001-6492-3849</p>2019

    <p>Graft versus host disease (GvHD) caused by alloreactive donor lymphocytes is a fatal complication of hematopoietic stem cell transplant (HSCT). Myeloablative conditioning regimen, consisting of chemotherapy and/or radiation, given prior to HSCT can cause tissue damage. This non-specific tissue …

    uthsc Repository record

  4. Immunological Mechanisms of Extracorporeal Photopheresis In Cutaneous T Cell Lymphoma and Graft Versus Host Disease

    Shiue, Lisa2013

    … lymphoma (L-CTCL) and graft versus host disease (GVHD), but whether the mechanism(s) of action in these two diseases is (are) identical or different is unclear. To determine the effects of ECP <em>in vivo</em>, we studied regulatory T cells (T-regs), cytotoxic T lymphocytes (CTLs), and dendritic …

    uthsc Repository record

  5. The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease

    Liu, Liangyi2015

    Graft-versus-host disease (GVHD) remains the major complication after allogeneic hematopoietic stem cell transplantation (HSCT), resulting from immunological attack on target organs such as gastrointestinal (GI) tract, liver and skin from donor allogeneic T cells. The most common treatment for GVHD …

    iupui Repository record

  6. Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease

    Boagni, Drew, <p>0009-0001-9639-5064</p>2023

    … but can also cause graft versus host disease (GVHD), which is characterized by systemic inflammation and organ damage mediated by dysregulated donor T cells. Preclinical studies have shown invariant natural killer T cells (iNKT) cells can prevent GVHD while preserving GVL. iNKT cells are …

    uthsc Repository record

  7. Investigation of the Efficacy of a Novel CsA Formulation Alone or in Combination with Cell Therapy in a Humanised Mouse Model of GvHD

    Corbett, JenniferNational University of Ireland Maynooth2016

    … such as acute Graft versus Host Disease (aGvHD). Cyclosporine (CsA) is an immunosuppressive drug commonly used as prophylaxis and treatment of aGvHD. However, oral bioavailability of CsA is suboptimal. The elucidation of MSC and CsA interactions will be beneficial as aGvHD patients in …

    maynooth Repository record

  8. Novel clinic-laboratoristic parameters and biochemical markers of iron status affect global mortality and GVHD risk in patients undergoing allogeneic hematopoietic stem cell transplantation

    Cilloni, Daniela, Nicoli, PaoloUniversità degli Studi di Torino2019

    unito Repository record

  9. Allogeneic Double Negative T cell Therapy as a Novel Treatment for AML Patients

    Lee, Jong Bok2019

    … toxicity such as graft-vs.-host disease (GvHD) remain as major issues that hamper recipients' survival. Many forms of immunosuppressants to control GvHD increase the risk of disease relapse, and therefore, there is an unmet need for a treatment that can target chemotherapy-resistant blasts …

    toronto-retro Repository record

  10. Immune Regulatory Role of Human CD141+ Dendritic Cells in Humanised Models of Alloimmunity

    Ali, NiwaKing's College London2013

    … occurrence of Graft-versus-Host Disease (GvHD) is a prevalent and<br/>potentially lethal complication that develops following hematopoietic stem cell<br/>transplantation. Humanized mouse models of xenogeneic-GvHD based upon<br/>immunodeficient strains injected with human peripheral blood …

    kings Repository record

  11. Biodistribution and Modes of Action of Multipotent Adult Progenitor Cell therapy in Murine Models of Transplant Rejection

    Carty, FionaNational University of Ireland Maynooth2018

    … (HP) and Graft versus Host Disease (GvHD) are major barriers to the success of transplantation. Multipotent Adult Progenitor Cells (MAPC cells) have demonstrated promising safety and therapeutic profiles in experimental models and small clinical trials of transplantation and acute …

    maynooth Repository record

  12. Donor lymphocyte infusion after allogeneic stem cell transplantation in children

    이, 성욱2014

    … by the development of graft-versus-host disease (GVHD)and marrow aplasia, and the efficacy of DLIis not defined in children. So we evaluate DLI for last decade, and wantedtodescribeDLIoutcomesinasinglecenter. METHODS: We analyzed 8 patients who received a total of18 granulcyte colony stimulating …

    ajou Repository record

  13. Role of Lymphocyte Populations Following Allogeneic Haematopoietic Stem Cell Transplantation // Роля на лимфоцитните популации след алогенна трансплантация на хемопоетични стволови клетки

    Petrov, Yavor, Петров, ЯворMedical University of Varna2025

    … of complications – graft-versus-host disease (GVHD), infectious complications (viral, bacterial, fungal), non-infectious complications (dysfunction of various organs and systems), and delayed or incomplete recovery of the immune system. Following allo-HSCT, immune system reconstitution is a …

    varna Repository record

  14. Adoptive cell therapy using primary T lymphocytes with genetically engineered T cell receptors against melanoma and glioma

    Soto, CarolinaUniversity of Illinois at Urbana-Champaign2013

    … in development of graft-versus-host disease (GVHD) in some mice. In chapter 4, mice affected by GVHD were studied in detail. Clinical signs, physical GVHD presentation, and GVHD-associated histopathology were dissected to better understand the mechanisms and factors involved in the in vivo …

    uiuc Repository record

  15. A Delineation of Mesenchymal Stromal Cell Therapeutic Action in New Models of Acute and Chronic Graft versus Host Disease

    Healy, Marc E.National University of Ireland Maynooth2015

    … already demonstrated beneficial effects during GvHD and Crohn’s disease. However, the mechanisms employed by MSC therapy to modulate disease progression have not been identified. The key goals for this thesis were (1) to determine how MSC effect B cell function and to identify the mechanisms by …

    maynooth Repository record

  16. Biological Assessment of Thioamide and Amide-Containing Chalcogenorhodamine Dyes as Photosensitizers for PDT of Cancer, ECP, and GVHD & Synthesis and Evaluation of Oligothiophene-Containing Chalcogenorhodamine Dyes for Biological and Photochemical Applications

    Linder, MichelleState University of New York at Buffalo2018

    Ph.D.

    buffalo Repository record

  17. Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy

    Liu, Wei-Hsin, <p>https://orcid.org/0000-0003-4670-7485</p>2026

    … causing significant graft-versus-host disease (GvHD). These veto Tcm eliminate donor-specific T cell clones via a Fas-FasL-signaling pathway. However, the underlying mechanism of their interaction with alloreactive NK cells remains elusive. By transplanting nude mice with allogeneic T …

    uthsc Repository record

  18. THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE

    McIver, ZachariahWake Forest University2017

    … acute graft-versus-host-disease (GVHD) is caused by an attack on the recipient's tissues from donor allogeneic T cells. In cutaneous T cell lymphoma (CTCL), malignant T cells migrate throughout the skin to mediate the disease. Consequently, developing new therapeutics to …

    wfu Repository record

  19. Stimulation of donor t-cells with leukemic blast-loaded dendritic cells for the generation of leukemia-specific immunity in the context of allogeneic stem cell transplantation

    Gil Alves Portugal, Tatiana

    … often complicated by graft versus host disease (GVHD), a potential lethal effect mediated also by donor T cells that target host tissues. Since different donor T-cell subsets may be responsible for the GVHD and GVL, it is desirable to generate more specific anti-leukemia cells, which would …

    freiburg-diss Repository record

  20. Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation

    김, 형일2011

    … grade II to III acute graft-versus-host-disease (GVHD) and 3 patients developed chronic GVHD. The median survival time in all patients was 60.27 months, the 5-year survival rate was 61.0% in the IST group and 81.9%(p=0.144) in the BMT group. The factors influencing overall survival were age under …

    ajou Repository record

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