Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 188 for “"GTPases"”.
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Evolution of antiviral breadth in Mx GTPases
As obligate parasites, viral pathogens coopt host resources and subvert cellular processes to promote their own replication. In response, host organisms have evolved numerous countermeasures to thwart viral infection. However, the molecular basis for how host antiviral defenses overcome the …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
<p>Several studies have identified Rho family GTPases (i.e. Rho, Rac, Cdc42) as mediators of diverse critical cellular processes, such as actin cytoskeleton remodeling, gene transcription, cell-cell adhesion, and cell cycle progression. However, more recent data highlight an essential role for Rho …
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Activation of lipid kinase VPS34 by Rab GTPases
… to engage with membranes. I have found that Rab GTPases act as specific regulators for each complex. While Rab5 is a strong activator for endocytic complex II, Rab1 specifically activates the autophagic complex I. To gain insight into the activation mechanism, I obtained a 9.8 Å resolution …
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Development of stapled peptides targeting the Ral GTPases
… been substantial evidence implicating the Ral GTPases, RalA and RalB, which are activated downstream of Ras, as critical drivers of cell growth and metastasis in numerous Ras-driven cancers. Therefore, targeting this pathway may provide an effective method for inhibition of oncogenic Ras …
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Characterization of Vibrio VopS, an AMPylator of Rho GTPases
Vibrio parahaemolyticus is a gram-negative marine bacterium that causes gastroenteritis associated with the consumption of contaminated shellfish. The emergence of pandemic strains of V. parahaemolyticus has increased the need for characterization of the virulence factors of this pathogen. …
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Alleviating ribosomal stalls: functional characterization of conserved Drg GTPases
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… ability to induce expression of families of GTPases. Herein, I describe my work characterizing the immunomodulatory activity of two families of interferon-inducible GTPases: the guanylate-binding proteins (GBPs) and the immunity related GTPases (IRGs). Previous studies have associated these …
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A New Approach To Identifying Effectors and Regulators of Small GTPases
… system. It is widely accepted that small GTPases of the Ras superfamily are major regulators of membrane trafficking and signalling, ensuring specificity and efficiency through their spatiotemporal regulation.Identifying the proteins interacting with small GTPases is vital for …
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Intracellular Lipid Surveillance Through Interplay Between a Nuclear Receptor and Rab GTPases
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
The Rho family of monomeric GTPases regulates a wide range of cellular processes including cytoskeletal structure, motility, cell division, gene transcription, vesicular transport, and various enzymatic activities. Activation of Rho proteins largely depends on Rho Guanine nucleotide Exchange …
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The generation and characterization of transgenic mice expressing modifiers of Rho GTPases
… in a wide variety of organisms. Small GTPases of the Rho family have been suggested to be involved in the regulation of formation of neurites and their differentiation into axons and dendrites, but the function of Rho GTPases is not still clear in terms of axonal and dendritic growth …
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Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
The Semaphorin-Plexin signaling is important for regulating axon guidance. Binding of Semaphorin to the Plexin receptor induces the dimerization of Plexin and stimulates its cytoplasmic GAP activity towards Rap, resulting in cytoskeleton re-organization. The growth cone of an axon then turns …
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Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
… OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Rho GTPases regulate a diverse spectrum of cellular functions involved in vascular morphogenesis. Here, we show that Cdc42 and Rac1 play a key role in endothelial cell (EC) lumen and tube formation in 3D collagen matrices, and that their regulation is …
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Rho GTPases and their regulators in cell polarity of the filamentous ascomycete Neurospora crassa
Rho-GTPasen sind kleine G-Proteine der Ras-Superfamilie, die als molekulare Schalter wirken: Im GTP-gebundenen Zustand aktivieren sie eine Vielzahl von Effektorproteinen, wohingegen sie durch die Hydrolyse des GTPs wieder inaktiviert werden. Rho-GTPasen nehmen eine Schlüsselstellung in zahlreichen …
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RabAnalyser: a computational framework to explore the cell-to-cell variability of Rab GTPases organization
L'abstract è presente nell'allegato / the abstract is in the attachment
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Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration
… T-ALL cells in the tissues. Rap and Rho family GTPases play key roles in T cell adhesion and migration and are often involved in cancer progression. Most of these proteins are post-translationally isoprenylated to facilitate their anchorage to membranes, where they function to stimulate signal …
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UNDERSTANDING THE RAL GTPASES: THE REGULATION BY PROTEIN LYSINE FATTY ACYLATION, SIRT2, AND INTERACTING PROTEINS
The RAS superfamily of small GTPases are molecular switches that control a wide range of cellular processes. Detailed understanding of these small GTPases is important for elucidating cell signaling mechanisms and identifying new disease treatment strategies. My thesis is centered on understanding …
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DHHC PROTEIN ACYLTRANSFERASES CATALYZES THE LYSINE PALMITOYLATION OF MEMBERS OF THE RAS SUPERFAMILY OF SMALL GTPASES
… labeling the lysine residues of multiple GTPases. This acylation event is confirmed as lysine fatty acylation through the use of the SIRT2 in-vitro defatty-acylation assay and mutagenesis of the modification sites and P-32 NAD + assay. Knockdown of the zDHHC7 gene was able to perturb the …
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