NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 8 of 8 for “"GTPase activation"”.

  1. Compartmentalized Rho GTPase activation is associated with effects on actin binding proteins

    Seifert, JenniferTexas Woman's University2008

    twu Repository record

  2. Investigating the mechanisms of protein synthesis using multi-resolution structural data

    Trabuco, Leonardo G.University of Illinois at Urbana-Champaign2010

    … structure of elongation factor Tu leads to its GTPase activation, a crucial step in the decoding of genetic information. Next, we investigated structural and regulatory aspects of ribosomes in complex with a protein-conducting channel, which transports certain nascent proteins across or into …

    uiuc Repository record

  3. Regulation of RhoA Activation and Actin Reorganization by Diacylglycerol Kinase

    Ard, RyanUniversité d'Ottawa / University of Ottawa2012

    Rho GTPases are critical regulators of actin cytoskeletal dynamics. The three most well characterized Rho GTPases, Rac1, RhoA and Cdc42 share a common inhibitor, RhoGDI. It is only recently becoming clear how upstream signals cause the selective release of individual Rho GTPases from RhoGDI. For …

    ottawa-retro Repository record

  4. Polyphosphate Modification of Human Proteins and a New Mechanism for Regulating Super-Enhancer Activity

    Yang, Zhiyun2026

    … the transcriptional regulator NKAP, suppressed GTPase activation of the oncogenic driver KRAS, and reduced the helicase activity of DDX55. Building on this framework, this study also identified a previously unrecognized role for polyP in transcriptional regulation through its direct interaction …

    queens Repository record

  5. Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth

    Reddy, JairusTexas Woman's University2015

    Rho family guanine nucleotide triphosphatases (GTPases) are molecular switches that play a fundamental role in axon growth and guidance by directing growth cone cytoskeletal changes through interaction with downstream effectors. Small GTPases are considered active when bound to guanosine …

    twu Repository record

  6. OVERT AND LATENT PATHWAYS OF POLARITY SPECIFICATION IN ZYGOTES: THE HAPLOID-TO-DIPLOID TRANSITION

    Rinonos, Serendipity ZapantaCase Western Reserve University School of Graduate Studies2013

    … medial pathway, independent of the Ras-like GTPase Bud1, and 2) a latent, Bud1-GTPase-dependent, non-medial pathway, elicited bydeletion of the transmembrane protein Rax1 and/or elimination of mitochondrial DNA. In zygotes which lack functional mitochondria, expression of ATP1-111, a mutant …

    ohiolink Repository record

  7. The WXXXE Effector Map Functions as a Potent and Specific Guanine Nucleotide Exchange Factor for CDC42

    Wallenfang, Adam James2010

    … Common targets for these effectors are small GTPases, particularly those controlling the actin cytoskeletal architecture. GTPases are molecular switches found within a diverse consortium of eukaryotic signaling pathways. As their name denotes, the primary enzymatic activity of GTPases is the …

    utswmed Repository record

  8. Rho GTPases in Neuronal Apoptosis and Neurodegeneration

    Stankiewicz, Trisha2001

    <p>Several studies have identified Rho family GTPases (i.e. Rho, Rac, Cdc42) as mediators of diverse critical cellular processes, such as actin cytoskeleton remodeling, gene transcription, cell-cell adhesion, and cell cycle progression. However, more recent data highlight an essential role for Rho …

    denver Repository record