Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"GTPase activating proteins"”.
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… morphological transformations. A group of proteins linked to the regulation of cytoskeletal dynamics are the small GTPases of the Rho family. Small RhoGTPases are regulated by GTPase exchange factors (GEF) and GTPase activating proteins (GAP), which can switch GTPases into "on or off" …
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Mechanisms of Multivesicular Body Biogenesis and Exosome Release
… Exosomen gefunden.Rab Guanosin triphosphatasen (GTPases) sind Regulatoren des intrazellulären Membransortierung. Um die Wirkung der GAPs (GTPase activating proteins) auf Exosomenfreizetzung zu untersuchen, wurde ein Screen eingesetzt. Die Expression von TBC1D10B, RN-tre, TBC1D10A, TBC1D10C und …
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Genetic Analysis of Grinder Formation in Caenorhabditis Elegans: Regulation by RAB-6.2 and Its GTPase Activating Protein EAT-17
… found that eat-17 encodes an ~825 amino acid Rab GTPase activating protein with a series of C-terminal coiled-coil domains. Its closest human homolog is Evi5, a putative oncogene whose function is not currently understood. Rabs are key regulators of vesicle transport, and cycle between active, GTP …
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Dual Regulation of Phospholipase C-beta by G betagamma
… diacylglycerol (DAG). PLC-b isoforms are also GTPase activating proteins (GAPs) for Gaq, and Gbg subunits inhibit the GAP activity of PLC-b. Coordinated regulation of these activities is essential for sustained signaling at steady state. Regulation of PLC-b by Gaq and Gbg is well studied but …
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Linking WRP/srGAP3 to the Cognitive Deficits in 3p- Syndrome and Its Role in the Regulation of Dendritic Filopodia Formation
<p>Rho GTPase signaling regulates a wide variety of cellular functions in the developing and adult central nervous system. These molecular switches are in turn spatially and temporally regulated by an over abundance of positive and negative regulatory proteins: the activating guanine nucleotide …
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
Rho GTPases and their regulators such as guanosine exchange factors (GEFs) and GTPase activating proteins (GAPs) represent an important class of molecules controlling dendritic spine plasticity. Although they are typically described as cytoskeletal modulators, roles for the GTPases in endocytosis …
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Characterization of the Role of R7-RGS Proteins in Mammalian Retina and Vision
… of the Role of RGS7-family Proteins in Mammalian Retina and Vision</p><p>by</p><p>Matthew David Cain</p><p>Doctor of Philosophy in Biology and Biomedical Sciences</p><p>Molecular Cell Biology</p><p>Washington University in St. Louis, 2014</p><p>Professor Kendall J. Blumer, …
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Molecular genetic investigation of the variability of the GTPase activating protein- (GAP-) related domain of the tuberous sclerosis-2 (TSC2) gene in TSC patients and healthy subjects
… codes for tuberin. Tuberin shows homology to GTPase activating proteins (GAPs) and hamartin and tuberin may interact with one another to control the cell cycle, suggesting a tumor suppressor function for these proteins. <br>Efforts to screen patient populations for mutations in both genes in …
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Molecular Genetic Analysis of Tumor Cells and Developmenet of RNA Interferance Therpy in Neurofibromatosis Type1(NF1)
… protein, neurofibromin, functions as a Ras-GTPase activating protein, nothing is known about how it is normally regulated or its precise role in controlling Ras signaling pathways. Neurofibromin deficiency typically causes chronic activation of Ras, considered the major contributor to …
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Blood Vessel Development
Cardiovascular system is the first developing functional organ in vertebrates, and one of the fundamental organ systems through adulthoods. Cardiovascular function depends on patent blood vessel formation by endothelial cells. In this dissertation, a careful analysis of different aspects of blood …
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Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
… fatty acid and cholesterol synthesis. The Rab GTPase activating proteins Akt substrate of 160 kDa (AS160) and tre-2/USP6, BUB2, cdc16 domain family member 1 (TBC1C1) have been identified as potential targets of both protein kinase B (PKB, also known as Akt) and AMPK which mediate glucose …