Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 348 for “"GTPase"”.
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Nanoscale Organization of The Small Gtpase Rac1
<p>Rac1 is a small, guanine-nucleotide binding protein that cycles between an inactive GDP-bound and active GTP-bound state to regulate actin-mediated motility, migration, and adhesion. Plasma membrane (PM) localization is essential for its biological activity. Rac1 PM targeting is directed by a …
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Characterization of Fluorescent biosensor for Rab11 GTPase
L'abstract è presente nell'allegato / the abstract is in the attachment
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The Arf GTPase exchange factor Sec7p interaction network:
The Golgi apparatus is the main crossroad of the intracellular trafficking network in all eukaryotic cells and plays a crucial role in the distribution of cellular material. To ensure the proper sorting and delivery of cargo proteins to their destination while maintaining Golgi homeostasis the …
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Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
Rho family GTPases act as molecular switches in the regulation of diverse cellular functions, including cell division, gene transcription and neurotransmission. In the model organism Caenorhabditis elegans, the Kalirin and Trio ortholog UNC-73 contains two RhoGEF domains that specifically activate …
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Reconstitution Of Rho Gtpase Interactions At The Membrane
… a robust morphological change. The Rho Family of GTPases play critically important roles in mediating these cellular processes. However, in order for the Rho GTPases to help regulate these processes in a tightly coordinated spatial and temporal manner, they need to be properly localized to …
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… of cytoskeletal dynamics are the small GTPases of the Rho family. Small RhoGTPases are regulated by GTPase exchange factors (GEF) and GTPase activating proteins (GAP), which can switch GTPases into "on or off" states, respectively. It is thought that GEFs and GAPs function as …
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Untersuchungen zur stimulierten GTPase von EF-Tu aus Thermus thermophilus
… geschwindigkeitsbestimmenden Schritte der DABP-GTPase und der GTPase unterscheiden sich. Bei der GTPase ist der nuklophile Angriff, bei der DABP-GTPase ein Protontransfer, vermutlich die Protonierung des gamma-Phosphates, der langsamste Schritt der Reaktion. iii) Bei der DABP-GTPase spielt, im …
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Regulation of Blood Vessel Development via Rho Family GTPase Signaling
The Rho family of small GTPases has been shown to be required in endothelial cells (ECs) during blood vessel formation. However, the underlying cellular events controlled by different GTPases remain unclear. Here, we assess the cellular mechanisms by which Rho family GTPase proteins and their …
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
<p>Activation of Rho family small G proteins is thought to be a critical event in breast cancer development and metastatic progression. Rho protein activation is stimulated by a family of enzymes known as guanine nucleotide exchange factors (Rho GEFs). The neuroepithelioma transforming gene 1 …
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The Small GTPase Rheb Is Required for Spermatogenesis but not Oogenesis
… evaluate the role of Rheb, a member of the small GTPase superfamily and a critical component for mTORC1 activation, in male and female gametogenesis. The function of Rheb in development and the nervous system has been extensively studied, but little was known about its role in the germline. I have …
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Alteration of prenylation: Effect on neurite outgrowth and Rho GTPase signaling
… of prenylation precursors that alter Rho GTPase localization and loading of GTP. We show here that lovastatin decreases neurite initiation and concurrently increases GTP loading of RhoA in the cytosol and decreases GTP loading of Racl associated with the plasma membrane. We also assess how …
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Regulation of septum formation by RHO4 GTPase signalling in Neurospora crassa
… und ist bei Eukaryoten hoch konserviert. Die Rho GTPasen sind in ihrer Funktion als Schlüsselregulatoren zahlreicher zellulärer Prozesse auch wesentlich an der Zellteilung beteiligt. Über die genauen Funktionen der Rho Proteine und deren Regulation in diesem Prozess war zu Beginn meiner Arbeit …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… One such protein <i>Af</i>Rho1 is a Rho GTPase, plays essential roles in fungal physiology and cell wall organization. In this research, I combined X-ray crystallography and fragment-based small molecule screening by BLI (Biolayer interferometry) to investigate the ligandability of …
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Identification and Characterization of Effectors/Binding Molecules for the Small GTPase Rab15
… the pericentriolar recycling\r\nendosome. Rab GTPases regulate specific membrane trafficking steps including vesicle\r\nbudding, vesicle transport and fusion with downstream target compartments. Rab\r\nfunction is mediated by the cyclical binding and hydrolysis of GTP, which in …
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Rho GTPase family members in establishment of polarity in C. elegans embryos
… by RNA-mediated interference (RNAi) of two Rho GTPases, CDC-42 and RHO-1. To examine how Rho GTPases are implemented in actin remodeling, it is important to analyze how their activity is controlled and how different activities affect polarity formation. The role of two putative Rho GTPase …
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Die GTPase Dynamin A : strukturelle und biochemische Hinweise auf einen molekularen Motor
Die GTPasen der Dynamin-Familie besitzen eine einheitliche Domänenstruktur, erfüllen aber sehr unterschiedliche biologische Funktionen, wie die Vesikelgenerierung in der Endocytose, den Erhalt der Mitochondrienmorphologie und die Abwehr von viralen Pathogenen. Während die biologische Funktion …
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Characterisation of the expression profile and endothelial function of Rho GTPase RhoJ
Rho GTPases are molecular switches that regulate many aspects of cell physiology. A number of Rho GTPases are essential for the formation of new vessels from pre-existing ones, a process known as angiogenesis. RhoJ/TCL belongs to the Cdc42 subfamily of Rho GTPases. Previous bioinformatic and …
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Signalling and function of the small Rho GTPase RhoJ in endothelial cells
RhoJ is an endothelial expressed Rho GTPase, and its knock-down impairs endothelial cell (EC) migration and tubulogenesis, increases stress fibre (SF) and focal adhesion (FA) numbers. This work aimed to determine the intracellular localisation of RhoJ, identify its binding partners, test how it is …
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