Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"GTP-binding protein"”.
-
FUNCTIONAL CHARACTERIZATION OF DENND5A/RAB6IP1 IN EARLY EMBRYONIC DEVELOPMENT
… cells, Dennd5a or Denn domain containing protein 5a is also named Rab6 interacting protein 1 (Rab6ip1), KIAA1091 (HUGE database). Rab6 is a small GTP-binding protein that involves in intra-Golgi transport. In a yeast two hybrid screen by Bruno Goud group in 1995, they used Rab6 as bait and …
-
Genetic and cytological investigation of Nucleostemin-1 in Drosophila melanogaster
Mammalian nucleostemin (NS) is a nucleolar GTP-binding protein implicated in cell cycle progression, stem cell proliferation, and ribosome assembly. Drosophila melanogaster contains a four-member nucleostemin family (NS1-4). Nucleostemin 1 (NS1) is the closest orthologue to human NS; it shares 33% …
-
Interactions of the Striatal Gene Rhes with the Dopaminergic System in Rodents
Mice that are incapable of expressing the small G protein Rhes have been generated and have shown to have abnormalities in behaviors mediated by the striatum, a region in which Rhes is highly expressed. Moreover, conditions that result in dopamine supersensitivity and a breakdown in D1/D2 synergism …
-
Mechanisms of HIV-Nef Induced Endothelial Cell Stress: Implications of HIV-Nef Protein Persistence in Aviremic HIV Patients
… production of HIV encoded pro-apoptotic protein, such as Nef in latently HIV-infected cells is a possible mechanism for vascular dysfunction underlying these diseases. HIVNef persists in two compartments in these patients: (i) extracellular vesicles (EV) of plasma and bronchoalveolar …
-
Molecular characterization of motility genes in Bacillus subtilis
… as flhF, was found to encode for a putative GTP-binding protein that displayed sequence similarities to components of the eukaryotic secretory apparatus. Subsequent biochemical analysis demonstrated that FlhF can bind to GTP and GDP, but not to ATP. FlhF is the first GTP-binding flagellar …
-
Characterization of the Saccharomyces cerevisiae gene MGP1, a novel member of the ras gene superfamily that functions in the mitochondrial biogenesis
… characterizes Mgp1p, a mitochondrial protein that functions in mitochondrial biogenesis. Mgp1p is the first protein related to the p21[superscript] H-ras oncoprotein shown to function in mitochondria;The Saccharomyces cerevisiae gene MGP1 was isolated based on its ability to restore …
-
Amyloid β Aggregation is Coupled to Cellular Metabolism and Intramitochondrial Proteostasis
… However, little is known about the dynamics of protein self-assembly, and effective inhibitors have not yet been identified. This lack of success can be associated with limitations affecting the standard techniques employed to study peptide self-assembly. Drawbacks include the inability to …
-
Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype
… aldehyde dehydrogenase 1A3 (ALDH1A3) and the GTP-binding protein/crosslinking enzyme tissue transglutaminase (tTG), two proteins suspected to have key roles in tumor initiation and the development of the malignant state, in glioma stem cells (GSCs). Additionally, I examined the contributions …
-
Dual Regulation of Phospholipase C-beta by G betagamma
Agonist-bound G protein coupled receptors (GPCRs) activate G protein heterotrimers by catalyzing release of GDP and binding of GTP to the G alpha subunit (Ga), releasing active Ga and G betagamma (Gbg) subunits. Activated alpha subunits of the Gq family and betagamma subunits of the Gi family …
-
GENOME EDITING, A NEW BIOTECNOLOGICAL APPROACH TO PRODUCE LYCOPENE-RICH PIGMENTED ORANGES
… fitoene sintasi (PSY), beta ciclasi 2 (β-LCY2) e GTP binding-protein (geni legati alla sintesi e accumulo di licopene) in polpa e albedo di arancio dolce, pompelmo e pummelo ricchi in licopene, confrontandoli con i corrispettivi mutanti non pigmentati ampliando, in questo modo, la conoscenza dei …
-
LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
Leucine-Rich Repeat Kinase 2 (LRRK2) is a large protein encompassing multiple functional domains, including kinase and GTPase enzymatic activity and several protein-protein interaction modules. It is expressed in the central nervous system (CNS) and it is among the most important genetic risk …
-
Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
The Rho family of monomeric GTPases regulates a wide range of cellular processes including cytoskeletal structure, motility, cell division, gene transcription, vesicular transport, and various enzymatic activities. Activation of Rho proteins largely depends on Rho Guanine nucleotide Exchange …
-
Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
… cytoskeleton, cell migration and cell shape. Rho GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This cycle is mediated by guanine nucleotide exchange factors (GEFs) that increase the rate of dissociation of GDP by stabilizing the nucleotide-free state of the …
-
Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… how a hyperactivating mutation of the Rac1 GTPase (Rac1P29S) harnesses Rac1's function as a regulator of actin polymer assembly to sustain cell cycle progression in growth limiting conditions. This proliferative advantage supports metastatic colonization of melanoma cells and confers …
-
The Effects of Rhes on Opioid Analgesia
… has been identified as a novel monomeric G-protein involved in dopaminergic and other signaling in the striatum. Given the many effects of opioids that involve striatal circuitry, genetically engineered mice that are incapable of making Rhes (rhes-/-) and their control littermates (rhes+/+) …
-
Studying the Molecular Mechanisms for Generating Progenitor Cells during Tail Regeneration in Ambystoma mexicanum
… are an effective tool to downregulate protein expression in urodele cells in vivo and in culture. Testing the role of two candidate genes in muscle fiber dedifferentiation, the homeobox containing transcription factor Msx1 and Rad, a GTP-binding protein of a new Ras-related protein …
-
Dissecting the Role of the Lipodystrophy Protein Seipin in the Biogenesis of the Lipid Droplet Organelle
… forces, or a regulated process driven by protein factors. The Goodman laboratory previously found evidence to suggest that seipin, mutated in the most severe cases of congenital generalized lipodystrophy, may be a key factor in the early stages of lipid droplet formation. Seipin resides at …
-
Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long Term Depression That Is Affected in Fragile X Syndrome
… depression (LTD) that requires rapid, dendritic protein synthesis. The significance of protein synthesis-dependent mGluR LTD to cognitive function is highlighted by the recent finding that mGluR-dependent LTD is enhanced and protein synthesis-independent in the mouse model of fragile X syndrome …
-
Regulation of Guanine Nucelotide Exchange in Inhibitory G Protein Alpha Subunit by Activator of G Protein Signaling 3 and Novel Regulatory Peptides
The release of GDP from the nucleotide binding pocket of G protein a subunit (Ga) is accelerated by guanine nucleotide exchange factors (GEFs) and inhibited by guanine nucleotide dissociation inhibitors (GDIs). The beta gamma subunit of heterotrimeric G protein and GoLoco motif are GDIs. Activator …
-
Cellular pathways of angiotensin II signalling in the hypertrophic myocardium
… linked to the degree of ventricular hypertrophy. GTP binding protein Gs alpha and Gi alpha subunits were assessed by ADP ribosylation, and immunodetection of Gs alpha. A diminution in the concentrations of these proteins in the hypertrophic Dahl S ventricular myocytes in comparison to Dahl R …
Page 1 of 2