Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"GTP-Binding Proteins"”.
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Small gtp-binding proteins in insulin secretion
… GSIS involves interplay between small G-proteins and their regulatory factors. Herein, I tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide exchange factor [GEF] for the small G-protein Arf6, mediates the activation of Arf6, and that ARNO/Arf6 …
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The generation and characterization of transgenic mice expressing modifiers of Rho GTPases
… Recent studies have suggested that Rho family GTP-binding proteins are important components of the signalling pathways that link the reception of extracellular cues to the cytoskeleton. Rho family GTP-binding proteins regulate many different aspects of the actin cytoskeleton in a wide variety …
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Regulation of apoptosis and desmosomes by RhoE
… epidermal function. A key group of signaling proteins that have been clearly implicated in epidermal function are the Rho family of small GTP-binding proteins. This thesis focuses on one member of the family, RhoE/Rnd3, and the analysis of the role it plays in the regulation of proliferation, …
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Rab11 Regulates Lumen Formation and Morphogenesis in the Developing Pancreas
… In addition, a literature review of Rho GTPase signaling in the vasculature reinforces many of the fundamental roles of various signaling molecules that also govern pancreas development. These reports link a number of cellular processes in vivo, and presents tantalizing possibilities for …
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Hematopoietic-specific regulation of the human hex1/hex02 human rac2 genes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effects of Regional Deletion of Rab3A-interacting Molecule and PTEN on Brain Function
This dissertation describes experiments designed to delete/knockdown molecules from targeted neuronal populations to study brain region-specific behavioral functions. To this end, I utilized two different conditional knockdown techniques to study the role of the presynaptic active zone molecule …
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Rab5 Activation by the Vps9 Domain
The movement of proteins through the endocytic pathway is a complex and highly regulated process. Not only is this pathway used to internalize cellular nutrients, but it is also used to modulate a cell's response to extracellular stimuli. Internalization and subsequent trafficking of transmembrane …
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Dynamic Scaffolding in a G-Protein Signaling Cascade
The file named "mishraprashant.pdf" is the primary dissertation file. Supplemental movie files ("Mishra_Movie_S1.mpg", "Mishra_Movie_S2.mpg") are also available.
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The Small GTPase Rheb Is Required for Spermatogenesis but not Oogenesis
… evaluate the role of Rheb, a member of the small GTPase superfamily and a critical component for mTORC1 activation, in male and female gametogenesis. The function of Rheb in development and the nervous system has been extensively studied, but little was known about its role in the germline. I have …
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Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival
The transport of proteins between organelles is a highly regulated and complex process that is crucial for many of the functions required for cellular homeostasis. Many distinct proteins are involved in each trafficking step with roles in vesicle formation, budding, movement, and fusion. One class …
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Rab5 Activation by the Vps9 Domain
The movement of proteins through the endocytic pathway is a complex and highly regulated process. Not only is this pathway used to internalize cellular nutrients, but it is also used to modulate a cell's response to extracellular stimuli. Internalization and subsequent trafficking of transmembrane …
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Endolysosomal Function in Neuronal Maintenance
The file named "JIN-DISSERTATION-2018.pdf" is the primary dissertation file. All other files ("*.mp4") are supplemental files and may be viewed individually.
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The Assembly of Pathogenic Signaling Circuits by a Family of Bacterial Secreted Effector Proteins
Bacterial type III secreted effector proteins facilitate Gram-negative bacterial replication, dissemination, and immune evasion in the infected host organism. While much attention has been focused on the cell inhibitory mechanisms of these virulence factors, there is emerging evidence that …
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The regulation of the CAMP signalling pathway in the human pathogenic fungus, Paracoccidioides brasiliensis
… and Walmsley, 2000; Kronstad et al., 1998). G proteins are guanine-nucleotide (GDP or GTP) binding proteins that are generally associated with the cytoplasmic side of the plasma membrane. They receive signals from G protein-coupled receptors (GPCR). Adenylyl cyclase acts downstream of these G …
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The Role of Rac1 in Synaptic Plasticity, Learning and Memory
… system. Rac1, a protein of the Rho subfamily of GTP binding proteins (GTPases), is largely known for its involvement in cytoskeleton remodeling, and has been implicated in neuronal development, participating in the morphological changes required for migration of newborn neurons to characteristic …
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Localization and Function of Bacterial Type III and IV Effector Proteins
… relay in both space and time. Bacterial effector proteins are virulence factors that are directly secreted from the bacteria into the host cytosol and function to rewire eukaryotic signaling networks to establish an environment for bacterial survival. While much effort has gone into substrate …
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Identifizierung neuer Interaktionsproteine des humanen Septins SEPT4 (hCDCrel-2) in fetalem Gehirn
Septine sind eine neue Untergruppe der GTP-bindenden Proteine. Die Septine vermitteln ihre Funktionen als heteropolymere Komplexe. In mitotischen Zellen sind Septine vorwiegend in Zytokinese und in postmitotischen Zellen vor allem in Exozytose involviert. In dieser Doktorarbeit wurden folgende neue …
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Intracellular Lipid Surveillance Through Interplay Between a Nuclear Receptor and Rab GTPases
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The regulation of luteinizing hormone exocytosis in α-toxin permeabilized sheep anterior pituitary cells
… molecules such as ATP while larger cytosolic proteins such as lactate dehydrogenase were retained. Because of the slow exchange of small molecules through a-toxin pores a protocol was developed which combines prolonged pre-equilibration of the permeabilized cells at 0°C before stimulation with …
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Regulation of Blood Vessel Development via Rho Family GTPase Signaling
The Rho family of small GTPases has been shown to be required in endothelial cells (ECs) during blood vessel formation. However, the underlying cellular events controlled by different GTPases remain unclear. Here, we assess the cellular mechanisms by which Rho family GTPase proteins and their …
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