Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"GSTT1"”.
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Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
… the common gene deletion polymorphism of GSTT1 and GSTM1 genes, for other GST genes (GSTP1 and GSTO2) SNP haplotypes were constructed. A rare GSTO2 haplotype was negatively associated with asthma susceptibility, atopy severity, and FEV1 values. Asthmatic children with a GSTT1 gene …
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Genetic Polymorphisms and the Treatment Outcome in Standard-Risk Pediatric Acute Lymphoblastic Leukemia
… 0.107). A combination analysis of the GSTM1 and GSTT1 genotypes revealed a stronger association between the both the GSTM1 and GSTT1 normal genotype and an increased risk of leukemia relapse (HR = 2.73, 95% CI = 0.9 - 7.9, P = 0.063), compared with patients having either the GSTM1 or GSTT1 null …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
… 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.
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Effects of aflatoxin B₁ (AFB₁) on hepatic gene expression in pigs and turkeys
… 6 (FAS), glutathione S-transferase theta 1 (GSTT1), cyclin G1 (CCGN1), proteasome activator subunit 1 (PSME1), proteasome activator subunit 3 (PSME3), and cytochrome P450-2A19 (CYP2A19). There were no differences in the expression of the genes among the treatments except for GSTT1 and CYP2A19 …
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Estudio multiple de polimorfismos genéticos en pacientes con linfoma de células B maduraú
… - Determinar si la presencia de genotipos de GSTT1 constituye un factor de riesgo para el desarrollo de neoplasias maduras de células B en individuos expuestos. Considerando como factores de exposición: al tabaco, el residir en una zona próxima donde exista alta concentración de industrias …
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Influence of molecular and genetic factors of the organism΄s antioxidative system on cervical carcinogenesis and the role of these factors in treatment of locally advanced cervical cancer /
… significant incidence of deletions in GSTM1 and GSTT1 genes among these groups, it can be stated, that in event of polymorphism of genes mentioned above, the probability to develop cervical cancer is higher. This study may be useful in selecting groups of women at high risk of developing cervical …
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Entwicklung und Anwendung von Methoden zur Untersuchung der in vivo-Alkylierung in Abhängigkeit von der Tabakrauchexposition mit Hilfe unterschiedlicher Biomarker
… der Glutathion-S-Transferasen GSTM1, GSTT1 und GSTP1 lag. Die Hauptaufgabe der vorliegenden Arbeit bestand darin, geeignete Methoden zum Nachweis der genannten Verbindungen zu entwickeln oder in geeigneter Weise weiterzuentwickeln, so dass unter den Gesichtspunkten der Anwendbarkeit im …
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Xenobiotic Metabolism Genes and Clubfoot
… CYP1A2, CYP1B1, CYP2A6, EPHX1, NAT2, GSTM1 and GSTT1) were genotyped in a dataset composed of nonHispanic white and Hispanic multiplex and simplex families. Only one SNP in CYP1A1, rs1048943, had significantly altered transmission in the aggregate and multiplex NHW datasets (p=0.003 and …
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Exposure, health effects, immunological markers and biomarkers of susceptibility among Swedish rubber workers
… with GSTM1*1 while the opposite were found for GSTT1. The effects of polymorphism in GSTA1-52 (G/A+A/A) on symptoms in exposed workers showed a consistent pattern of a protective effect. The results indicate that workers in the contemporary rubber industry develop symptoms and thus, the work …
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Genetic polymorphisms in breast cancer in relation to risk and prognosis
… CYP2C8*4, CYP2C9*2, CYP2C9*3, GSTM1*0 and GSTT1*0 were evaluated and haplotype blocks constructed. CYP2C8/9 *1/*4/*1/*1 was associated with a lower frequency of axillary lymph node involvement as compared with the wild type in tumors larger than 20 mm, OR 0.13 (95% CI 0.04-0.45; P=0.001). …