Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"GSTP1"”.
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Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection
… in the mammalian cell. Among GST, the Pi class (GSTP1) is the most prominent extrahepatic isoform in humans, and it is well documented that increased expression of this enzyme is present in human tumours and can contribute to anticancer drug resistance, involving many compounds which are not …
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Identifying mutational landscape and inflammatory pathways associated with lung squamous premalignant lesion progression
… has identified that Glutathione S-transferase P (GSTP1) is up-regulated in PMLs that remain stable as dysplastic lesions or progress into advanced dysplastic lesions, suggesting that there is an anti-correlation between the expression of GSTP1 and immunological responses. Understanding the …
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Tailored chemotherapy based on genomic polymorphisms for metastatic colorectal cancer treated with 5-fluorouracil plus oxaliplatin or irinotecan in Korean patients
… PCR-based RFLP 방법을 사용하여 TS, MTHFR-977, XPD-751, GSTP1-105, XRCC1-399, UGT1A1*28 유전자에 대해 분석한 후 다형성에 따라 약제를 선택하여 항암화학치료를 시행하였다. 3주기 시행 후 반응도를 평가하였다. 결과: 44명의 환자가 연구에 참여되었으며 32명의 환자에서 FOLFOX용법으로, 12명의 환자에서 FOLFIRI용법으로 치료받았다. 전체 환자에서 완전관해는 없었으며 맞춤화학치료에 대한 반응율은 43.2%(19명)였다. 유전자 다형성에서 XPD-751, …
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Cellular uptake and actions of bilberry anthocyanins in retinal pigment epithelial cells
… (HO-1) and glutathione S-transferase (GSTP1) proteins in RPE cells by 1.5- to 2-fold over untreated cells in 6 hours and, at pharmacologic doses, up-regulate HO-1 as much as 10-fold over a 24-hour period. Bilberry anthocyanins and phenolics were shown to induced increases in HO-1 and …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
… glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.
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Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
… of GSTT1 and GSTM1 genes, for other GST genes (GSTP1 and GSTO2) SNP haplotypes were constructed. A rare GSTO2 haplotype was negatively associated with asthma susceptibility, atopy severity, and FEV1 values. Asthmatic children with a GSTT1 gene deletion, or a common GSTP1 haplotype, developed …
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Enrichment of tomatoes and broccoli with specific bioactives for the reduction of prostate carcinogenesis
… apo-10’-lycopenal, on methylation of the GSTP1 promoter in LNCaP cells. GSTP1 is hypermethylated in >90% of prostate cancers, which results in complete silencing of the gene. Neither lycopene nor apo-10’-lycopenal altered mRNA expression or DNA methylation of GSTP1 indicating that lycopene …
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Candidate genes other than the CFTR gene as possible modifiers of pulmonary disease severity in cystic fibrosis
… GSTM1 and T1 (gene deletion polymorphisms), GSTP1 (Ile105Val) and GCLC repeats, 4) mucin genes (MUC2 and MUC5B). Pulmonary disease progression and survival in patients with chronic Burkholderia cepacia complex (BCC) infection were also investigated controlling for genomovar and RAPD type of …
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Chemotherapeutic drugs, 5-fluorouracil and cisplatin, differentially affect exprssion of drug metabolising enzyme genes in an oesophageal cancer cell line
… DME-encoding genes, CYP1A1, 1A2, 1B1 and GSTP1, in a human oesophageal cancer cell line.
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Comparación de perfiles de metilación de genes supresores tumorales en distintos subgrupos de tumores vesicales no músculo-invasivos
… tiempo libre de enfermedad para WT1 (p=0.019), GSTP1 (p=0.034) y BRCA1 (p=0.031) en TaBG, para CDKN2A (p=0.022), PAX6 (p=0.026), ATM (p=0.002) y RB1 (p=0.006) para T1BG y para PAX5A (p=0.04), PTEN (p=0.017) y PYCARD (p=0.007) en T1AG. En el análisis multivariado, se confirmaron los genes WT1 …
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Investigating mechanisms of ovotoxicity of Perfluorooctanoic acid and Zearalenone exposure and the influence of altered metabolic status on ovarian function
… The levels of ovarian EPHX1, CYP2E1 and GSTP1 proteins were evaluated by western blots of protein isolated from prepubertal pigs held in a thermal-neutral environment with ad libitum access to a standard swine diet, a thermal-neutral environment with a restricted access to a standard …
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Reaction of the marine flatworm Macrostomum lignano exposed to xenobiotics
… and Mdr5. Of the ROS-detoxifying enzymes, only Gstp1 showed significant upregulation. Xenobiotics also disrupt nervous system function by restricting movement and delaying regeneration. Even at low concentrations (10 µM), fipronil and imidacloprid reduce peripheral nerve function. I demonstrated …
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Identifying genetic biomarkers for diagnosis of prostate cancer in South African men
… the PCa group with p values s <0.05; IGF1, PTEN, GSTP1, SOCS3, EGR3, GPX3, TIMP3, ZNF185, DKK3, PTGS2, FOXO1, ARNTL, TNFRSF10D, CCND1, and DLC1, upregulated genes included; CDH1, MKI67, TMPRSS2, ERG, CDKN2A, FASN, and AR but were not statistically significant. At a fold change threshold of 1.5, …
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Entwicklung und Anwendung von Methoden zur Untersuchung der in vivo-Alkylierung in Abhängigkeit von der Tabakrauchexposition mit Hilfe unterschiedlicher Biomarker
… der Glutathion-S-Transferasen GSTM1, GSTT1 und GSTP1 lag. Die Hauptaufgabe der vorliegenden Arbeit bestand darin, geeignete Methoden zum Nachweis der genannten Verbindungen zu entwickeln oder in geeigneter Weise weiterzuentwickeln, so dass unter den Gesichtspunkten der Anwendbarkeit im …
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An Activity-Based Proteomics Approach for Identifying Ajoene's S-thiolation Protein Targets in Blood and Cancer Cells
… S-thioallylates glutathione S-transferase (GSTP1), which is a known cancer-therapy target in breast cancer. Overall, this study complements findings on the cancer-cell protein targets of allicin from crushed garlic, by identifying proteins regulating apoptotic and antiproliferative …
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Lutein and α-tocopherol biodistribution in animal models
… genes (CD36, SCARB1, SCARB2, LDLR, STARD3, GSTP1, BCO1, BCO2, or RPE65). Dietary regimen did not impact the expression of carotenoid-related genes except for SCARB2. However, carotenoid-related genes were differentially expressed across brain and retina regions. Breastfed infants had higher …