Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"GSTM1"”.
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The Association of Specific EPHX1 and GSTM1 Gene Polymorphisms with Phenytoin- or Smoking-Associated Birth Defects
… no apparent correlation between the EPHX1 and GSTM1 genotypes examined and mEH enzyme activity or phenotype associated with FHS. Our observed allele frequencies at EPHX1 codon 113 for the cigarette smoke exposure population were not comparable to allele frequencies reported by Hassett et al. …
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Functional genomics in the stroke-prone spontaneously hypertensive rat: genome wide and candidate gene analysis
… gene, glutathione s-transferse mu type 1 (Gstm1). Ingenuity pathway analysis of renal microarrays in 5 and 16-week SHRSP, normotensive Wistar Kyoto (WKY) and chromosome 2 congenic rats identified differential expression of several glutathione cycling genes. The Gstm1 promoter was …
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Assessing Hepatic Gene Expression in Response to Xenobiotic Exposure in Mice
… d 8, and glutathioneâ Sâ transferase (Gst) mu1 (Gstm1; P = 0.049) on d 11 was increased, and sulfotransferase 5a1 on d 11 decreased (P = 0.02). Sulforaphane increased expression of cytochrome P450 1a2 on d 5 (P = 0.02) and flavin containing monooxygenases 1 on d 11 (P = 0.002), both phase I …
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Genetic Polymorphisms and the Treatment Outcome in Standard-Risk Pediatric Acute Lymphoblastic Leukemia
… of disease relapse in this study cohort. The GSTM1 null genotype was associated with a decreased risk of disease relapse (HR = 0.394, 95% CI = 0.127 - 1.224, P = 0.107). A combination analysis of the GSTM1 and GSTT1 genotypes revealed a stronger association between the both the GSTM1 and GSTT1 …
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Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4-Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Production
… and a HepG2 cell line model. Co-expression of GSTM1 + MRP1 leads to increased HNE-protein adducts formation and sensitization to HNE cytotoxicity (0.44 fold). Expression of GSTM1 alone and MRP1 alone leads to moderate but significant sensitization (0.7- 0.8 fold). GSH depletion was significant …
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Genetic analysis of thymocyte apoptosis
… including Glutathione-S-Transferase M1 (GSTM1) and Nur77 expression, and NFB function, however no specific mechanism for activating GR-regulated apoptosis has been determined. Apoptosis is also induced in immature mouse thymocytes by ceramide analogues, staurosporine, and Fas stimulation, …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
… (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.
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Candidate genes other than the CFTR gene as possible modifiers of pulmonary disease severity in cystic fibrosis
… and SPD (Thr11Met), 3) antioxidant genes GSTM1 and T1 (gene deletion polymorphisms), GSTP1 (Ile105Val) and GCLC repeats, 4) mucin genes (MUC2 and MUC5B). Pulmonary disease progression and survival in patients with chronic Burkholderia cepacia complex (BCC) infection were also investigated …
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Exposure, health effects, immunological markers and biomarkers of susceptibility among Swedish rubber workers
… markers was found. Exposed workers with the GSTM1*O genotype had lower levels of TTCA compared to exposed workers with GSTM1*1 while the opposite were found for GSTT1. The effects of polymorphism in GSTA1-52 (G/A+A/A) on symptoms in exposed workers showed a consistent pattern of a protective …
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Effects of close-up dietary energy strategy and prepartal dietary monensin on hepatic mRNA expression of enzymes involved in glucose and lipid metabolism in transition cows
… stress genes (TNF, IL6, HP, GSTM1), growth hormone/IGF-1 axis genes (GHR, IGF1) and transcription factors (FOXA2, HNF4A, NR4A1, SREBPF2). In cows fed the CON diet, serum NEFA concentrations were higher at -2 and -1 week relative to calving and serum BHBA concentrations were …
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Acute Lymphoblastic Leukemia in Adolescents and Young Adults in Finland
… resulted in a model of four genes: BAK1, CDKN2B, GSTM1, and MT1F. The copy number profile combinations of these genes differentiated between AYA ALL patients at diagnosis depending on their risk of relapse. Deletions of CDKN2B and BAK1 in combination with amplification of GSTM1 and MT1F were …
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Investigating Clozapine-Induced Myocarditis in Stem Cell-Derived Cardiomyocytes from Treatment-Resistant Schizophrenia Patients: A Pharmacoepigenomic Approach
… at the promoter regions of genes such as GSTM1 and ZNF559, which was correlated with decreased gene expression. Conversely, hypermethylation in the gene bodies of AKAP7 and HLA-DRB1 was associated with increased expression. In conclusion, my study highlights the critical role of epigenetic …
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Influence of molecular and genetic factors of the organism΄s antioxidative system on cervical carcinogenesis and the role of these factors in treatment of locally advanced cervical cancer /
… significant incidence of deletions in GSTM1 and GSTT1 genes among these groups, it can be stated, that in event of polymorphism of genes mentioned above, the probability to develop cervical cancer is higher. This study may be useful in selecting groups of women at high risk of …
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Effects of essential amino acids supply and body condition prepartum on antioxidant, inflammation and mechanistic target of rapamycin pathways in adipose tissue during the periparturient period
… 1 (GPX1), GPX3, glutathione S-transferase mu 1 (GSTM1), and glutathione S-transferase alpha 4 all related to GSH metabolism. There was a diet×day effect for protein abundance of NFE2L2 and its repressor kelch like ECH associated protein 1 due to lower values at 30 d in cows fed Met versus …
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Entwicklung und Anwendung von Methoden zur Untersuchung der in vivo-Alkylierung in Abhängigkeit von der Tabakrauchexposition mit Hilfe unterschiedlicher Biomarker
… Phase-II-Enzymen der Glutathion-S-Transferasen GSTM1, GSTT1 und GSTP1 lag. Die Hauptaufgabe der vorliegenden Arbeit bestand darin, geeignete Methoden zum Nachweis der genannten Verbindungen zu entwickeln oder in geeigneter Weise weiterzuentwickeln, so dass unter den Gesichtspunkten der …
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Xenobiotic Metabolism Genes and Clubfoot
… (CYP1A1, CYP1A2, CYP1B1, CYP2A6, EPHX1, NAT2, GSTM1 and GSTT1) were genotyped in a dataset composed of nonHispanic white and Hispanic multiplex and simplex families. Only one SNP in CYP1A1, rs1048943, had significantly altered transmission in the aggregate and multiplex NHW datasets (p=0.003 …
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Genetic polymorphisms in breast cancer in relation to risk and prognosis
… of CYP2C8*3, CYP2C8*4, CYP2C9*2, CYP2C9*3, GSTM1*0 and GSTT1*0 were evaluated and haplotype blocks constructed. CYP2C8/9 *1/*4/*1/*1 was associated with a lower frequency of axillary lymph node involvement as compared with the wild type in tumors larger than 20 mm, OR 0.13 (95% CI 0.04-0.45; …
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Proteomic approaches for the identification of biomarkers of beef tenderness from Longissimus thoracis muscles and plasma of young Limousin-sired bulls
… APOA4 and HP-20 (plasma), PFKM, MYH2, PTER, GSTM1 and MYPN (muscle) were good predictors of tenderness, juiciness and chewiness. Five explanatory models were built to explain various beef quality traits, specifically, MYOZ3, BIN1 and OGN for WBSF; CACNA2D1, EIF5A, STBD1, WDR1 for tenderness; …
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Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
… common gene deletion polymorphism of GSTT1 and GSTM1 genes, for other GST genes (GSTP1 and GSTO2) SNP haplotypes were constructed. A rare GSTO2 haplotype was negatively associated with asthma susceptibility, atopy severity, and FEV1 values. Asthmatic children with a GSTT1 gene deletion, or a …
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Estudio multiple de polimorfismos genéticos en pacientes con linfoma de células B maduraú
… los genes que codifican a las enzimas: Ø GSTT1 y GSTM1; conocidas como Glutatión-transferasas participan en la desintoxicación de compuestos electrofílicos, incluyendo los agentes carcinógenos, de drogas terapéuticas, de toxinas ambientales y de productos de la tensión oxidativa, por la …
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