Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"GSK3B"”.
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… understood. Glycogen synthase kinase 3 beta (GSK3b), a multifunctional serine/threonine kinase, is involved in many cellular processes. GSK3b also participates in neoplastic transformation, tumor development and regulate cancer cell metastasis. Inactivation of GSK3b contributes to tumor …
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Gsk3B Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties and Is A Novel Drug Target For Triple-Negative Breast Cancer
<h1><strong>Abstract</strong><strong></strong></h1> <p><strong>GSK3β regulates Epithelial-Mesenchymal-Transition and Cancer Stem Cell properties and is a novel drug target for Triple-Negative Breast Cancer.</strong></p> <p>Geraldine Vidhya Raja, MS.</p> <p>Advisory Professor: Sendurai Mani, …
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Mechanisms Regulating The P120-Catenin/Kaiso Pathway
… of destruction-complex components such as GSK3b or Axin promotes p120-catenin degradation, and consequently, is able to rescue developmental phenotypes resulting from p120 over-expression during early <em>Xenopus</em> embryonic development. Conversely, as predicted, the in vivo depletion of …
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The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study
… single nucleotide polymorphisms (SNPs) within GSK3B, AKT1, ARRB2, GRIA2 and PPPARGC1A could be associated with the incidence and severity of lithium-induced side effects.
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
… in einem GAL4-System gezeigt. Rekombinantes GSK3b phosphorilierte die Transaktivierungsdomäne von Pax6 und ein CBP-Fragment, das die Aminosäuren 2040-2305 enthielt. Dies konnte durch in vitro Kinase assays gezeigt werden. Die Ergebnisse zeigen, das GSK3-b in die Regulation des Glucagongens …
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Regulation of Reparative Macrophage Transition by the B-cell Adapter for PI3K (BCAP)
… of BCAP hinders inactivation of FOXO1 and GSK3b that contributes to their enhanced inflammatory state. BCAP deficiency also results in defective aerobic glycolysis and reduced lactate production. This translates into reduced histone lactylation and decreased expression of reparative …
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Charakterisierung des mit der Alzheimer Krankheit assoziierten Genprodukts Presenilin 1 und Interaktion mit beta-Catenin
… von MDCK Zellen konnte durch Inhibition der GSK3b ein Aktivieren des Wnt-Signaltransduktionsweges nachgeahmt werden, was zu einer Anreicherung des intrazellulären bCatenins führte. Gleichzeitig konnte festgestellt werden, dass die Menge an sekretiertem Ab-Peptid in Abhängigkeit von der …
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Genetic Dissection of the Exit of Pluripotency in Mouse Embryonic Stem cells by CRISPR-based Screening
… differentiation I found that the pattern of GSK3b phosphorylation is highly correlated with differentiation phenotype. I conclude that mTORC1 is involved in pluripotency maintenance and differentiation through cross-talk with the Wnt signalling pathway. My screen has demonstrated the power of …
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Characterization of SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mx mice
… and a reduction in Ser9 phosphorylated GSK3b. However, no significant changes were seen throughout the hippocampus. Collectively, this thesis presents evidence suggesting impaired SERCA function in both C57 and D2 mdx brain – perhaps due to heightened oxidative/nitrosative stress.
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조골세포 사멸 및 분화에서 GSK3b의 역할
" Dfferentiation of osteoblasts is critically involved in bone formation and requires several signal pathways. One of the important pathways is the Wnt signaling where GSK3 plays a key role in regulation of β-catenin activity, a major effector, through phosphorylation. Glucocorticoids (GCs) are …