Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"GSK3 beta"”.
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… not well understood. Glycogen synthase kinase 3 beta (GSK3b), a multifunctional serine/threonine kinase, is involved in many cellular processes. GSK3b also participates in neoplastic transformation, tumor development and regulate cancer cell metastasis. Inactivation of GSK3b contributes to tumor …
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
The Wnt/Beta-catenin signaling pathway has many roles including regulation of developmental pathways, cell proliferation, and homeostasis of adult tissues. Wnt/Beta-catenin signaling activity depends on the stability and localization of Beta-catenin in the cell. In the absence of a Wnt-signal, …
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Cellular mechanisms of environmental enrichment: Novel discovery-based strategies for target identification for neuropsychiatric disorders
… target of AKT, glycogen synthase kinase 3 (GSK3) beta, with a novel adeno-associated viral (AAV) vector in the nucleus accumbens shell (NAcSh) of rats and found increases in depression-like and cocaine taking behaviors. Additionally, GSK3 beta knockdown significantly reduced the activity of …
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THE ROLE OF DOPAMINE D3 RECEPTORS IN THE CONTROL OF ALCOHOL INTAKE
… (assessed as phosphorylation of DARPP-32 and GSK3 beta) in striatum and prefrontal cortex. Forced ethanol intake increased the expression of RACK1 and BDNF in both WT and D3R-/-; in WT there was also a robust overexpression of D3R. Thus, increased expression of D3R associated with activation …
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Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
… of malignancies. Glycogen synthase kinase 3 (GSK3) was first discovered as the kinase responsible for phosphorylating and inhibiting the activity of glycogen synthase, ultimately antagonizing the storage of glucose as glycogen. Its activity counteracts the effects of insulin in glucose …