Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"GSK3β"”.
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Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
… We report that OS resulted in phosphorylation of GSK3β (inactivation) and p38MAPK (activation) that was associated with cell cycle arrest and senescence in amnion cells. Inhibitors to GSK3β and p38MAPK verified their roles. GSK3β inactivation was associated with nuclear translocation of …
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Wnt signaling in zebrafish fin regeneration : chemical biology using a GSK3β inhibitor
… pathway using a small molecule inhibitor of GSK3β was previously shown to increase markers of bone formation in vitro. Our study utilized a zebrafish model system to study Wnt activated fin regeneration and bone growth. Wnt signaling is the first genetically identified step in fin …
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Characterization of the Effects of bFGF and GSK3β Inhibitors on Embryoid Bodies Derived from Human Pluripotent Stem Cells
… of bFGF as well as small molecule inhibitors of GSK3β on the formation, growth, cell-cell signaling and early fate decisions of human EBs. bFGF or GSK3β inhibitor treated EBs grew in size and showed evidence of cell proliferation. Control EBs that were fed only a basal serum free EB medium …
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Gsk3B Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties and Is A Novel Drug Target For Triple-Negative Breast Cancer
… <p><strong>GSK3β regulates Epithelial-Mesenchymal-Transition and Cancer Stem Cell properties and is a novel drug target for Triple-Negative Breast Cancer.</strong></p> <p>Geraldine Vidhya Raja, MS.</p> <p>Advisory Professor: Sendurai Mani, Ph.D.</p> …
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조골세포 사멸 및 분화에서 GSK3b의 역할
… through the GC receptor. Dex activated GSK3β, and inhibition of GSK3β by lithium, a pharmacological antagonist, or gene knock-down by siRNA prevented the Dex-induced apoptosis. Unexpectedly, Dex also activated p38 mitogen-activated protein kinase (p38 MAPK); however, the inhibition of …
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Use it and boost it: cognitive and physical activities modulate cognition via BDNF-TrkB signaling
… BDNF-TrkB signaling and learning contribute to GSK3β inhibition in the hippocampus and striatum. We found that GSK3β inhibition in the hippocampus and striatum increased following place and response training, but not the priming task SA. Furthermore, we found no effects of blockade of BDNF-TrkB …
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An Investigation of the Role of Insulin Deficiency and Loss of PI3K-Akt Signaling Downstream Regulators GSK3β -CREB Signaling in the Pathogenesis of the Diabetic Brain
… insulin-mediated phosphorylation of CREB/GSK3β, critical neuronal signals downstream of PI3K-Akt pathway and direct support of these proteins will prevent these neurodegenerative changes. A transgenic murine model with downregulation of CREB in the forebrain was used to complement …
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Using Drosophila to study the contribution of human kinases to tau toxicity
… to enhance tau toxicity in flies. Only human GSK3β showed a robust enhancement of tau-mediated eye degeneration. For the first time I showed that a human kinase, GSK3β, could specifically phosphorylate human tau in Drosophila on sites not targeted by endogenous fly kinases. In particular, tau …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… during HSV latency and following reactivation. GSK3β is a key effector molecule that inter-connects Akt and β-catenin mediated pathways, forming an Akt-GSK3β-β-catenin signaling axis. Analyzing the Akt-GSK3β-β-catenin signaling in response to stress hormone and NTF deprivation revealed …
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Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway
… signal-regulated kinase (ERK1/2), Akt, and GSK3β 15 min after reperfusion. Brief administration of isoflurane 3min before and 2 min after the initiation of early reperfusion reducedinfarct size (56 ± 8% of left ventricular area at risk, mean ± standard deviation) compared with controls (68 ± …
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Mechanism on Elongated Mitochondria Formation during Iorn Chelation-Induced Senescent Arrest
… we observed the interaction between Drp1 and GSK3β and also found phosphorylation of Drp1, providing the clue of Drp1 regulation by GSK3β.
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Molecular and Cellular Signaling Mechanisms Elucidating Aldose Reductase Mediated Ischemia-Reperfusion Injury in the Myocardium
… to changes in glycogen synthase kinase 3β (GSK3β) phosphorylation, and whether an increased flux via AR and resultant I/R injury is mediated by changes in autophagy.
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Tumor-like growth of mouse embryonic stem cells
… supplemented with a pharmacological inhibitor of Gsk3β, they efficiently proliferated and developed into teratomas without upregulation of Eras and c-Myc, but had upregulated Gli2 expression. These findings indicate that Gli2 expression is tightly correlated with the incidence of tumor-like growth …
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
… memory subsets. It has been recently shown that GSK3β inhibition could arrest CD8+ T cell differentiation, trigger the formation of stem cell-like memory T cells, and a more functional state of CD8+ T cells. Therefore, we analyzed the effects of GSK3β inhibition on the homeostasis and function of …
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Role of lncRNA in cancer development and progression
… down the levels of p-AKT (Thr308 & Ser473) and p-GSK3β (Ser9), and accordingly, β-catenin, cyclin D1 and c-Myc expression were decreased, but p21cip1/Waf1 expression was increased. Together these data suggest that PICART1 is a novel p53-inducible tumor suppressor lncRNA, functioning through the …
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Insulin and TOR pathways regulate cellular and organismal growth through the myc oncogene in Drosophila
… activation is conditioned to AKT-dependent GSK3β/sgg inactivation. In fact, we were able to demonstate that dMyc protein stabilization through phosphorylation is a conserved feature between Drosophila and vertebrates and requires multiple events. The final phosphorylation step, that results …
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Parp Inhibitor Upregulates Pd-L1 Expression and Enhances Cancer-Associated Immunosuppression
… mouse tumors. Mechanistically, PARPi inactivates GSK3β, which in turn enhances PARPi-mediated PD-L1 upregulation. PARPi attenuates anticancer immunity via upregulation of PD-L1, and blockade of PD-L1 re-sensitizes PARPi-treated cancer cells to T cell killing. The combination of PARPi and …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… 5-HT1A receptor-mediated phosphorylation of GSK3β in the absence of changes in its canonical upstream kinase, Akt. These data suggest fluoxetine may induce changes in phosphatase activity or that there may be a different upstream kinase mediating the phosphorylation of GSK3β in the …
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The Role of p66Shc in Stem Cells: Signalling, Identity and Apoptosis
… pluripotency even in the absence of chemical MEK/GSK3β inhibition. These effects are consistent with a model in which p66Shc acts as a competitive inhibitor of Grb2 recruitment, restraining ERK–STAT3 signalling to promote lineage priming. In NSCs, p66Shc loss conferred resistance to apoptosis …
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