Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"GSK3"”.
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Gsk3 Mediates Signaling Upstream of Akt
… requirement of Glycogen Synthase Kinase 3 (GSK3), a serine-threonine kinase that participates in multiple cell signaling pathways downstream of Akt, for Akt inhibitor-induced Akt phosphorylation. siRNA-mediated knockdown of GSK3 in MDAMB231 breast cancer cells and in mouse embryonic …
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Understanding and Exploiting Wnt5a and GSK3 Signaling in Inflammatory Disease
… of atherosclerosis.Glycogen synthase kinase (GSK3), a ubiquitously expressed multifunctional serine/threonine kinase, participates in a multitude of cellular and physiological processes, ranging from cell cycle, both cell death and survival, transcription, translation, microtubule stability …
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Partial GSK3 knockdown improves muscle performance in mdx mice: investigating the cellular mechanisms
… down the enzyme glycogen synthase kinase 3 (GSK3) improved muscle strength and fatigue resistance in a preclinical model for DMD, the mdx mouse. However, the exact cellular mechanisms leading to these benefits remain unknown and is the purpose of the present thesis. To this end, male …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… understood. Glycogen synthase kinase 3 beta (GSK3b), a multifunctional serine/threonine kinase, is involved in many cellular processes. GSK3b also participates in neoplastic transformation, tumor development and regulate cancer cell metastasis. Inactivation of GSK3b contributes to tumor …
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Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
… of malignancies. Glycogen synthase kinase 3 (GSK3) was first discovered as the kinase responsible for phosphorylating and inhibiting the activity of glycogen synthase, ultimately antagonizing the storage of glucose as glycogen. Its activity counteracts the effects of insulin in glucose …
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
… Mechanismus in Hinblick auf die Rolle von GSK3 untersucht. Es konnte gezeigt werden, dass die Überexpression von GSK3 die Glucagongen Trankription verstärkte.GSK3 Inhibitoren unterdrückten die Trankripiton des Glucagongens und zeigten somit den selben Effekt wie Insulin. Untersuchungen an …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… Akt-mediated phosphorylation and inactivation of GSK3β in the kidney of male obese Zucker rats fed HSD for 48 hrs. The HSD intake resulted in proteinuria, which was significantly prevented by C21. Moreover, the expression of glomerular slit diaphragm proteins (nephrin and podocin) the estimated …
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Can low-dose lithium supplementation protect against sarcopenic obesity in ovariectomized mice?
… associated with age. Glycogen synthase kinase 3 (GSK3) is a well-known negative regulator of muscle mass, strength, and the oxidative fibre type, and has been associated with weight gain and obesity. Our lab has found that inhibiting GSK3 using low-dose lithium (Li) supplementation improves …
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
… coregulator, is phosphorylated by GSK3 Beta; in a complex with APC, AXIN, and CK1. Phosphorylation promotes ubiquitination of Beta-catenin and subsequent proteasomal degradation. When a Wnt-ligand binds to a Frizzled receptor, a signaling cascade displaces GSK3 Beta from its complex …
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
… we identified glycogen synthase kinase 3-beta (GSK3ß) inhibitors as likely candidates. We observed that pharmacological and genetic knockdown of GSK3 induced apoptosis and differentiation, preferentially in the CD133-expressing tumor-initiating fraction. In addition, GSC frequency was …
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Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes
… essentiality of Glycogen Synthase Kinase 3 (TbGSK3 short; Tb927.10.13780) and chemically validating it as a potential drug target in T. brucei. TbGSK3 recombinant protein was biochemically characterised and screened against a focussed kinase library using the KinaseGlo assay method. Further …
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Mecanismos implicados en la protección de la apoptosis neuronal en células granulares de cerebelo por lítio valproato
… la inactivación de la PKB y la activación de la GSK3. Como, además, el litio reduce la activación de las fosfatasas estudiadas planteamos la hipótesis de que el efecto neuroprotector del litio sea debido a que mantiene activa la vía antiapoptótica PI3K/PKB. Apoyando a la anterior hipótesis, hemos …
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Mécanismes de contrôle du facteur de transcription E2F4 dans les cellules épithéliales intestinales normales et cancéreuses
… ces événements: l'inhibition concomitante des GSK3?/? ou des p38?/? est aussi requise. En effet, la combinaison de l'EGF ou du FGF9 avec un inhibiteur pharmacologique des GSK3 entraîne la translocation nucléaire d'E2F4 et l'entrée en phase S. De manière analogue, l'inhibition des p38 en …
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DEVELOPMENT AND APPLICATION OF CHEMOENZYMATIC TOOLS TO VISUALIZE MAMMALIAN PHOSPHOLIPASE D SIGNALING
… a new role for glycogen synthase kinase 3 (GSK3) in regulating the transcription of PKC and PLD. This finding reveals that PKC levels are self-regulating as high PKC activity inhibits GSK3 and thus reduces its own transcription. Collectively, our studies developing and utilizing IMPACT …
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Cellular mechanisms of environmental enrichment: Novel discovery-based strategies for target identification for neuropsychiatric disorders
… target of AKT, glycogen synthase kinase 3 (GSK3) beta, with a novel adeno-associated viral (AAV) vector in the nucleus accumbens shell (NAcSh) of rats and found increases in depression-like and cocaine taking behaviors. Additionally, GSK3 beta knockdown significantly reduced the activity of …
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Gammabestrahlung führt zur CD95-abhängiger Invasivität in apoptoseresistenten Glioblastomzellen
… (ILK), der Inhibierung von GSK3 und der Expression der Matrix-Metalloproteinasen (MMPs). Caspasen sind an diesem Signalweg nicht beteiligt. Das direkte Verbindungsglied unterhalb des CD95-Rezeptors konnte in dieser Studie nicht detektiert werden. Das „phosphoprotein enriched …
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Proneural Genes in Neocortical Development
… was controlled by a simultaneous increase in GSK3 activity (Chapter 3). Furthermore I found that GSK3 inhibited Neurog2’s proneural activity through direct phosphorylation, which altered Neurog2-cofactor interactions. Next, I found that RAS/ERK signaling controlled a Neurog2-Ascl1 genetic …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… inhibition between glycogen synthase kinase 3 (GSK3) and Akt, which promote the activity of the transcription factors FoxO1 and CREB, respectively. Super-low-dose LPS mildly activated FoxO1 and pro-inflammatory gene transcription without inducing anti-inflammatory genes or activating CREB, and …
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Mechanistic Dissection of Tcf7l1-Dependent Enhancer Decommissioning During Exit from Naïve Pluripotency
… by Tcf7l1 upon releasing cells from Gsk3 inhibition. These findings suggest that Tcf7l1-mediated enhancer decommissioning serves as a critical mechanism by which pluripotent cells rapidly alter the response to signaling pathways in preparation for gastrulation, and it may be a …
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Molecular Mechanisms of Interleukin-1beta-Stimulated Regulation of Angiogenesis in Cardiac Microvascular Endothelial Cells.
… independent of MAPKs. IL-1β inactivated GSK3β via ERK1/2. Pharmacological inhibition of these signaling cascades indicated IL-1β-stimulated regulation of MMP-2 and VEGF-D occurs via ERK1/2, JNKs, and PKCα/β<sub>1</sub>-dependent mechanisms. In addition, inactivation of GSK3β inhibited …
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