Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"GSK-3beta"”.
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Roles of GSK-3beta and PYK2 signaling pathways in synaptic plasticity
… pathways, glycogen synthase kinase 3 beta (GSK- 3beta) and proline-rich tyrosine kinase 2 (PYK2), in LTD at rat hippocampal synapses. GSK-3beta, a serine/threonine kinase implicated in the pathophysiology of schizophrenia, mood disorders, and Alzheimer's disease, is known to play a critical …
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Synthesis and Pharmacological Evaluation of Novel anti-TB Agents and GSK-3beta Inhibitors.
… Evaluation of Novel anti-TB Agents and GSK-3beta Inhibitors.
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… bone repair including Sox9, Runx2, beta-catenin, GSK-3beta, and Axin. Lastly, alcohol-treated mice that received LiCl showed improved callus strength, restoration of normal cartilage formation and endochondral ossification in the callus tissue, and enhanced total and activated beta-catenin protein …
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Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
… (BIO) inhibition of GSK-3beta resulted in accelerated differentiation, instead of decreased differentiation, of CD133+ cells. BIO-treated CD133- cells that were differentiated maintained multipotency while proliferating at similar rates to vehicle-treated CD133+ cells …
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The Role of Atypical PKC in the Plasticity of the Circadian Clock in the Rat Suprachiasmatic Nucleus
… of aPKC. Studies on glycogen synthase kinase-3beta (GSK-3beta) and TIMELESS show that these two proteins may be regulated by aPKC in the rat SCN. A model is proposed that describes the current understanding of the glutamate signaling pathway mediated by aPKC in the early night in the rat SCN.
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
… of NFATc3 from the nucleus by inhibition of GSK-3beta and JNK activity. Arteries of diabetic patients display increased expression of the pro-inflammatory cytokine osteopontin (OPN). Furthermore, plasma levels of OPN have been shown to correlate to the progression of diabetic nephropathy and …
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Kardioprotektion durch Postkonditionierung gesunder Rattenherzen sowie von Herzen mit kardiovaskulären Risikofaktoren: Charakterisierung der Signaltransduktion unter besonderer Betrachtung von PI3-K/Akt, mTOR, ERK1/2 und GSK-3ß
… Weiteren konnte erstmals die Inaktivierung der GSK-3ß durch eine verstärkte Phosphorylierung über einen PI3-Kinase-vermittelten Signaltransduktionsweg nachgewiesen werden. Die Zugabe des spezifischen Inhibitors TDZD-8 der GSK-3ß verringert ebenfalls die Infarktgröße signifikant. Auch konnte zum …