Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"GSK-3β"”.
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Regulation of Foxc2 Expression and Function During Epithelial-Mesenchymal Transition By Gsk-3Β
… revealed two potential phosphorylation sites for GSK-3β. Furthermore, inhibition of GSK-3βsignificantly reduces FOXC2 protein. In addition, exposure of HMLE Twist cells expressing endogenous FOXC2 to the GSK-3β inhibitor, TWS119, results in accumulation of FOXC2 protein in the cytoplasm with …
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The Gsk-3Β-Fbxl21 Axis Regulates Tcap Via Ubiquitin-Mediated Proteasomal Pathway In The Cytoplasm
… tests, we identified Glycogen Synthase Kinase-3β(GSK-3β) as a regulator of FBXL21. Biochemical and molecular characterizations demonstrated that GSK-3β interacts with both FBXL21 and TCAP and affects Skp, Cullin1(Cul1), F-box containing (SCF) complex/E3 ligase-Substrate complex formation. …
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Molecular mechanisms of bioactive compounds in fruits and vegetables that inhibit pancreatic cancer and their relationship with inflammation
… serine/threonine kinase glycogen synthase kinase-3β (GSK-3β) that is known to translocate into the nuclei of pancreatic cancer cells and act as a key regulator of NF-κB transcriptional activity. The constitutively active NF-κB resulting from misregulation of this signaling cascade is an essential …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… colon cancer cells through phosphorylation of GSK-3β and activation of Tcf/Lef. Furthermore, LTD4 decrease both membranous E-cadherin and β–catenin which lead to an increase migration of HCT116 colon cancer. I also found that membrane expression of β–catenin is associated with good prognosis …
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The Regulation of Mtorc2 Kinase Activity and Complex Integrity
… of mTORC2 by glycogen synthase</p> <p>kinase-3β (GSK-3β). Under ER stress, the essential mTORC2 component, rictor,</p> <p>is phosphorylated by GSK-3β at Ser-1235. This phosphorylation event results in</p> <p>the inhibition of mTORC2 kinase activity by interrupting Akt binding to mTORC2.</p> …
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Targeting protein kinases to manage or prevent Alzheimer’s disease
… kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta (Aβ) levels is also possible through development of protein kinase C-epsilon (PKC-ϵ) activators to recover …
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Protein kinases: Structure modeling, inhibition, and protein-protein interactions
… kinase 2 (CDK2) and glycogen synthase kinase-3β (GSK-3β). We prepared a non-redundant database from 303 available CDK2 PDB structures. We removed all structural anomalies and proceeded to use the CDK2 database in studying CDK2 structure in its different states, upon ATP, ligand and cyclin …
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Investigations on the Effects of Palmitate on Neuronal Cells
… for 0, 5, or 10 minutes. Activation of AKT1 and GSK-3β was then analyzed by Western blot assay. Preliminary results suggested that while insulin-induced GSK-3β activation may not be affected by PA treatment, insulin-induced AKT1 activation appeared to be attenuated by PA treatment as compared to …
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EFFECTS OF REPEATED ARIPIPRAZOLE TREATMENT ON THE cAMP AND AKT PATHWAYS IN THE DORSAL STRIATUM OF PREADOLESCENT AND ADULT RATS
… of haloperidol significantly increased p-GSK-3β levels in young and adult rats, but neither haloperidol nor aripiprazole significantly affected GSK-3β, Akt, or p-Akt levels. Overall, the results of this thesis indicate that repeated aripiprazole and haloperidol treatment differentially …
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Cell Cycle Regulation by Post-Translational and Post-Transcriptional Mechanisms in an Anaerobic Extremist- the Anoxia Tolerant Turtle, Trachemys Scripta Elegans
… possible regulation by signaling cascades (Akt/GSK-3β and ATR/Chk2) that are known to regulate G1/G0 phases of the cell cycle. Importantly, there is extensive regulation of Cyclin D1 protein by (1) Akt/GSK-3β signaling, (2) post-translational modification, (3) an AU-rich region, and (4) …
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Effects of alcohol and ∆9-tetrahydrocannabinol on energy balance and cognitive behaviors
… and basal glycogen synthase kinase-3 beta (GSK-3β) activity in the medial prefrontal cortex (mPFC; center for executive function control), mediobasal hypothalamus (MBH; energy balance regulator), and hippocampus (HIP; involved in spatial learning) during drug abstinence. GSK-3β is a …
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Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
… cycle regulator glycogen synthase kinase (GSK) 3β and its regulation by p38MAPK in effecting senescence to further delineate the molecular mechanism involved in senescence. We report that OS resulted in phosphorylation of GSK3β (inactivation) and p38MAPK (activation) that was associated …
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Interplay Between Keratin and Vimentin Expression in Oral Cancer
… Wnt signaling removes the inhibition on GSK-3β and prevents activation of NF-κB, which decreases proliferation.</p>
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… TCAP oscillation and inhibited TCAP degradation. GSK-3β acts as an upstream kinase regulating TCAP degradation and activating FBXL21 E3 ligase function. This regulation was impaired in <em>Psttm</em> mice, and leading to reduced skeletal muscle output function.</p> <p>This dissertation highlights …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… decrease in Akt S473 phosphorylation, GSK-3β S9 phosphorylation, Akt activity, cell viability, increased apoptosis, and resulted in sensitization to proteasome inhibition-depended cell death in a synergistic manner. Proteasome inhibition using carfilzomib, an irreversible proteasome …
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Dissecting the role of cathepsin V in breast cancer
… of Akt, subsequently increases the pSer9 GSK-3β and ultimately reduces GSK-3β expression, resulting in the reduction of GATA3 degradation. These results suggest that cathepsin V enhance GATA3 stability via the PI3K/Akt-GSK3-β signalling pathway.<br/><br/>Work presented herein has also …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
… and dbcAMP stimulated phosphorylation of Akt and GSK-3β, suggesting the role of PI3K/Akt in PGE2-induced ICAM-1 expression. This inference was supported by the separate experiment using a PI3K inhibitor, LY294002, constitutive active (CA) and dominant negative (DN) Akt constructs. PGE2 induced the …
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Glycemic control and pancreatic beta cells protective effect of a lanosteryl triterpene from Protorhus longifolia in hyperlipidemic and STZ-induced diabetic rats
… expression along with increases in p-Akt, p-GSK-3β and GLUT 4 expression were observed in the RA-3 treated group vs untreated diabetic controls. Finally, the molecular basis of RA-3 in hyperlipidemic and STZ-induced type 2 diabetes in animals was studied. Diabetic animals treated with RA-3 …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… of PI3K/Akt along with subsequent activation of GSK-3β in response to low dose ATRA treatment. HL-60 cells treated with GSK-3β or proteosome inhibitors revealed marked accumulation of c-Myc both in the presence and absence of ATRA and TIS21, confirming ATRA plus TIS21 mediated c-Myc …
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