Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"GSK-3"”.
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Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
… the Nav complex, in neurons is controlled via a GSK-3 dependent signaling pathway (Shavkunov et al., 2013). Additionally, inhibition of GSK-3 reduces the assembly of FGF14:Nav1.2 complexes, redistributes FGF14 and Nav channels from the axonal compartment to the somatodendritic compartment, and …
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GSK-3 Inhibition: A Novel Approach to Sensitization of Chemo-resistant Pancreatic Cancer Cells
… kinase glycogen synthase kinase-3 (GSK-3). GSK-3 is a key mediator of pathways such as insulin, wnt, and PI3K/Akt and has roles in proliferation, glucose metabolism, apoptosis, motility and neuroprotection. Depending on the cellular context, GSK-3 activity can promote or inhibit cell …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… phosphorylation by glycogen synthase kinase-3 (GSK-3) causing β-transducin repeat-containing protein (β-TrCP) to ubiquitinate Nrf2 by Skp1-Cul1-F-box (SCF) ubiquitin ligase through the Neh6 domain of Nrf2. Several research groups have shown that induction of ARE-driven genes can be regulated by …
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De-Risking PET Radioligand Discovery for Neurodegenerative Diseases
… (CSF-1R); 2) glycogen synthase kinase-3 (GSK-3); and 3) transactivation response DNA-binding protein with molecular weight of 43 kDa (TDP-43). Utilizing autoradiography, a putative CSF-1R binding radioligand, [3H]CPPC, did not localize to microglia in the brain tissue of a preclinical …
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Role of the PI-3K/Akt and ERK pathways in phencyclidine-induced neurotoxicity in neonatal rats and the protection by lithium and BDNF
… factor, glycogen synthase kinase-3â (GSK-3â), evoked by PCP. Furthermore, blocking either the PI-3K/Akt or the ERK pathway abolished the protective effects of lithium and BDNF. Western blot analysis revealed that the PI-3K/Akt and ERK pathways were stimulated by lithium and BDNF …
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Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
… how activation of the Wingless (Wnt) pathway via GSK-3 inhibition can provide a novel approach to improve transplantation outcomes using expanded cells. In vitro and in vivo models of HSPC function were used to evaluate the impact of expansion and GSK-3 inhibition on progenitor function while …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
… OXPHOS, promoting lung metastases by inhibiting GSK-3 activity. Prune1's mitochondrial localization and interaction with ATP5A1 highlight its role in OXPHOS-mediated ATP production. The Prune1 inhibitor (LEO-AA7.5(S)T) was shown to impair tumor metastasis, enhance cell adhesion, and inhibit …
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Bioengineering of a TAT-conjugated Peptide to Modulate the Activity of Glycogen Synthase Kinase-3 in Adult and Embryonic Stem Cells
… peptide-inhibitor of glycogen synthase kinase-3 (GSK-3). TAT-eIF2B was found to be specific for GSK-3 and had a significant positive effect on the formation of neurospheres in embryonic stem cell cultures and on the survival of myeloid progenitors in cytokine-starved fetal liver cell cultures. On …
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Platiscity of C. Elegans Germline Stem Cells Under Nutritional and Metabolic Stress
… G1 is promoted by the metabolic regulator <em>gsk-3</em>. Loss of <em>gsk-3</em> inhibits S phase entry and progression through transcriptional down-regulation of <em>cdk-2</em>. Since metabolic signaling regulates <em>gsk-3</em>, I propose that controlling G1 progression may allow the cells to …
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Discovery of Novel Glycogen Synthase Kinase-3beta Inhibitors: Molecular Modeling, Virtual Screening, and Biological Evaluation
Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine protein kinase which is engaged in a variety of signaling pathways, regulating a wide range of cellular processes. Due to its distinct regulation mechanism and unique substrate specificity in the molecular pathogenesis of …
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Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression
… is now widely accepted that GSK-3 phosphorylation of the Neh6 domain of NRF2 is fundamental for SCFβ-TrCP-mediated degradation of the transcription factor. Previous work by other groups has indicated a potential role for a priming kinase to pre-phosphorylate the Neh6 domain …
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The effect of lifestyle modification on the insulin-signaling cascade among subjects with impaired glucose tolerance
… insulin receptor substrate(IRS)-1, Akt, and GSK-3 before and after insulin stimulation in subjects of normal control(n=15) and subjects with impaired glucose tolerance(n=14). We also assessed the protein level of atypical forms of protein kinase C(PKC-ξ/λ) and active form of membrane-bound …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… cells but was subject to repression by the GSK-3 inhibitor BIO compound in both E-box (putative Snail binding site)-dependent and -independent manner. My results indicate that there are other Snail-independent transcriptional regulations involved in the regulation of RKIP expression.
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… cells but was subject to repression by the GSK-3 inhibitor BIO compound in both E-box (putative Snail binding site)-dependent and -independent manner. My results indicate that there are other Snail-independent transcriptional regulations involved in the regulation of RKIP expression.
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Studies of the anti-cancer potential of flavonoids in Human Nasopharyngeal carcinoma cells
… of the Akt-glycogen synthase kinase-3beta (GSK-3?)-cyclin D1 signaling pathway. In the last third part of this study we examined the sensitisation effect of quercetin and luteolin, both used at sub-cytotoxic concentrations on apoptosis induced by vincristine, a commonly used cancer …
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The Effect of Weight Reduction on Chronic Inflammatory Molecules and Insulin Resistance in type 2 DM
… insulin receptor substrate(IRS)-1, Akt, and GSK-3, PAC-zeta, lambda, theta, delta, alpha, beta phosphorylation before and after insulin stimulation in 15 normal control group and 13 type 2 DM group and follow up 6 month later in 8 case type 2 DM. In DM group, we try to weight reduction by …
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Signaling Pathway Inhibitor Library Screening Reveals B-Catenin/TCF4 as a Novel Telomerase Regulator in Cancer cell lines
… or LiCl (activates Wnt signaling by inhibiting GSK-3?) treatment as well as overexpression of a constitutively active form of ?-catenin (?-N ?-catenin) up regulated hTERT mRNA expression and telomerase activity (TA) in cancer cell lines. On the other hand, knocking down of endogenous ?-catenin …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… an inhibitor of glycogen synthase kinase-3 beta (GSK-3-β). We analyzed biomarkers obtained from participants in a randomized placebo-controlled trial of lithium in ART-treated individuals with moderate or severe HAND. We assayed markers at baseline and 24 weeks across several pathways hypothesized …
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