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Showing 1 to 20 of 39 for “"GSIS"”.

  1. Studies of TNF- α-induced -GSIS Inhibition in INS-1 β-cell

    김, 효은2011

    … for regulation of plasma glucose concentration. GSIS depends on coordinated glucose uptakes, oxidative metabolism nd Ca(2+)+-triggered insulin exocytosis. Imparied GSIS is a hallmark of type Ⅱ Diabetes. It has been reported that TNF-α, proinflammatory cytokine, was increased in obese type Ⅱ …

    ajou Repository record

  2. Genistein-Induced Potentiation Effect on Glucose-Stimulated Insulin Secretion (GSIS) in INS-1 β-cells

    이, 수진2011

    … activity, had a potentiation effect on GSIS (glucose-stimulated insulin secretion) in pancreatic INS-1 beta cells. Although the potentiation effect was glucose-dependent, the signal involved in potentiation effect were not intensively studied. First, to determine whether genistein has …

    ajou Repository record

  3. Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes

    Rani, SwetaDublin City University2009

    … status. Glucose stimulated insulin secretion (GSIS) is lost in long-term cultured MIN6 heterogeneous cells. MIN6 B1, a clonal sub-line derived from MIN6, has been described as highly glucose-responsive. This study aimed to investigate the GSIS function, changes in gene expression and, …

    dcu Repository record

  4. Investigation of pancreatic beta cell differentiation and function, and global profiling analysis of diabetes serum for the identification of disease biomarkers

    Hennessy, EricaDublin City University2012

    … of glucose stimulated insulin secretion (GSIS), specifically the role of microRNAs (miRNAs) in this process. TaqMan low density miRNA arrays identified a panel of 10 miRNAs down-regulated in glucose non-responsive compared to glucose responsive MIN6 cells. Functional investigations …

    dcu Repository record

  5. New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology

    Schisler, Jonathan Cummings2010

    … glucose-stimulated insulin secretion (GSIS), and a gradual diminution of beta cell mass. To identify genes that are involved in GSIS and contribute to the mature beta cell phenotype, a panel of beta cell lines with varying capacities for GSIS was employed for a candidate gene screen. …

    utswmed Repository record

  6. Small gtp-binding proteins in insulin secretion

    Jayaram, Bhavaani2011

    … leading to Glucose-stimulated insulin secretion [GSIS] might serve as therapeutic potential towards diabetes. GSIS involves interplay between small G-proteins and their regulatory factors. Herein, I tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide exchange …

    wayne-thes Repository record

  7. Pyruvate Cycling Pathways and Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells

    Ronnebaum, Sarah Marie2008

    … decreased glucose-stimulated insulin secretion (GSIS), pyruvate cycling, and NADPH. Organic acid profiling revealed that decreased pyruvate cycling was compensated by an increase in lactate and stable pyruvate levels. This work established an important role for ICDc in maintaining GSIS through …

    duke Repository record

  8. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Olsson, Anders HDepartment of Clinical Sciences, Lund University2012

    … role in glucose stimulated insulin secretion (GSIS). The overall aim of this thesis was to explore the influence of genetic and epigenetic variation on OXPHOS, islet function and T2D in humans. In study I, we identified a single nucleotide polymorphism (SNP) in TFB1M, a nuclear-encoded factor …

    lund Repository record

  9. Shared Metabolic Pathways in Fuel-Stimulated Insulin Secretion

    Odegaard, Matthew Lester2009

    … during glucose-stimulated insulin secretion (GSIS) or glutamine oxidation or ATP production during amino acid-stimulated insulin secretion (AASIS). Similar to previous findings, glucose-induced NADPH production was determined to be decreased in response to OGC suppression, whereas NADPH …

    duke Repository record

  10. TRANSFORMATIVE LEARNING AND TEACHING: USING THE NATIONAL WRITING PROJECT`S TOOLS AND PRINCIPLES TO PREPARE GRADUATE STUDENT INSTRUCTORS TO FACILITATE FIRST-YEAR COMPOSITION

    Dunn, Valerie Michelle

    … and preparing graduate student instructors (GSIs) to teach first-year composition. This question arises out of the need for knowledge-building graduate student preparation programs that keep pace with the increased demands of the first-year composition course and of the first-year composition …

    siu-theses Repository record

  11. Processes controlling the behavior of LNAPLs at groundwater surface water interfaces

    Hawkins, Alison M., author, Sale, Tom, advisor, Zimbron, Julio, committee member, Ronayne, Michael, committee memberColorado State University. Libraries2013

    … at groundwater surface water interfaces (GSIs). Governing processes were investigated via laboratory studies and a preliminary analysis of forces controlling LNAPL occurrence in unsaturated media. A total of six laboratory sand tank experiments were conducted using novel applications of …

    colostate Repository record

  12. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

    Andersson, Sofia AUnit of Islet Cell Exocytosis2012

    … with glucose stimulated insulin secretion (GSIS) and negatively with HbA1c levels. Furthermore, silencing of Syt4, Syt7 and Syt13 in INS1-832/13 cells correlate with reduced levels of GSIS. In paper IV exocytosis in human beta-cells was studied to generate a risk score consisting of 4 SNPs …

    lund Repository record

  13. The impact of glucotoxicity on pancreatic β-cell function

    Jabar Muhammed, SarheedDiabetes Centre, Lund University2012

    … impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. The data showed abnormally increased expression of inducible nitric oxide synthase (iNOS) protein in the islets from …

    lund Repository record

  14. Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population

    Grudzien, Peter2016

    … blocked by gamma-secretase inhibitors (GSIs). While GSIs are currently in clinical trials for breast cancer, it is not fully understood how these compounds will affect CSCs or if CSCs from different breast cancer phenotypes will be differentially affected.</p><p>The stem cell-like …

    loyola-thes Repository record

  15. Regulation of Exocytosis by Syntaxin 4-Munc18c Complexes

    Jewell, Jenna Lee2010

    … defects in glucose-stimulated insulin secretion (GSIS) from the pancreatic beta cells in combination with defects in peripheral (muscle and adipose) tissue glucose uptake. Both GSIS and glucose uptake are regulated by Syntaxin 4 (Syn4)-Munc18c complexes. Importantly, reports link obesity and Type …

    iupui Repository record

  16. Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis

    Yeung, Ho YanUniversity of Cambridge2020

    … promoting glucose stimulated insulin secretion (GSIS) in the pancreatic β cells and inhibiting glucagon secretion in the pancreatic α cells. Given its proven clinical efficacy in reducing long term blood glucose level, GLP-1-based treatments, such as exenatide and liraglutide, have been widely …

    cambridge Repository record

  17. Three-dimensional structure of a type III glutamine synthetase by single particle reconstruction

    Van Rooyen, Jason MacraeUniversity of the Western Cape2007

    … in relation to the extensively characterised GSIs. GSIIIs are the most recently discovered family of GSs and are the most phylogenitically distant GSs from the GSIs. Images (160) of negatively stained rGlnA, expressed in E.coli YMC11 (glnA-), were recorded at 50K magnification using a Leo 912 …

    western-cape Repository record

  18. VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE

    Garibay, DarlineCornell University2018

    … of glucose stimulated insulin secretion (GSIS), enhancement of insulin sensitivity, and decreases in appetite. Given the known role of β-cell GLP-1R signaling in the potentiation of GSIS we investigated its role in the glucoregulatory benefits of VSG utilizing an inducible β-cell GLP-1R …

    cornell Repository record

  19. Assessment of the Efficacy of a Constructed Wetland to Reduce or Remove Wastewater Effluent Estrogenicity and Toxicity Using Biomarkers in Male Fathead Minnows (Pimephales Promelas Rafinesque, 1820)

    Hemming, Jon M.University of North Texas2000

    … stream and laboratory controls. Vitellogenin, GSIs (gonado-somatic indices), HSIs (hepato-somatic indices) and secondary sexual characteristics were biomarkers used in P. promelas models to assess aqueous estrogenicity. Biological indicators used to assess general fish health included …

    unt Repository record

  20. Mechanisms of regulation of islet function by nadph oxidase

    Syed, Ismail2012

    <p>Glucose stimulated insulin secretion (GSIS) involves a series of metabolic and cationic events, leading to translocation of insulin-laden secretory granules from a distal site toward the plasma membrane for fusion and release of insulin into circulation. Vesicular transport and fusion events are …

    wayne-thes Repository record

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