Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 305 for “"GSH"”.
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Very low HDL cholesterol: The GSH Experience
… lipid clinic at Groote Schuur Hospital (GSH) in Cape Town, South Africa. Eligible patients were identified by searching the GSH Lipid Clinic database and data was abstracted from their folders and entered into a Redcap database. Results One hundred and twenty eight (128) patient records …
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Retrospective review of radical cystectomies at GSH 1993-2007
The objective of the thesis was to look at the epidemiology of patients needing this procedure, clinical presentation and investigation, pathology, complications related to the procedure, adjuvant and neoadjuvant treatment, and survival.
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Determination of the Oxidative Capacity of Soot Toward GSH and Characterization of Soot Physicochemical Properties
… biologically relevant antioxidant, glutathione (GSH), was optimized for use as an indicator of oxidative stress to shed light on relevant particle characteristics. This was accomplished via fluorescent spectroscopy for GSH determination by way of reaction with <em>o-</em>phthalaldehyde (OPA), a …
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Molecular characterisation of Diffuse large B-cell lymphomas (DLBCL) diagnosed at Groote Schuur Hospital (GSH)
… DLBCL cases diagnosed at Groote Schuur Hospital (GSH) between 2015 and 2021 using FISH. Methods: FISH for MYC, BCL2, and BCL6 alterations was performed on formalin-fixed paraffin wax-embedded (FFPE) tissue according to manufacturer instructions. Each case was assessed for rearrangement and CNV. …
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A Decade of Hepatitis C at the UCT/GSH Liver Clinic in the Pre-DAA era
… our HCV experience at Groote Schuur Hospital (GSH) in the Pegylated interferon (Peg-IFN) and Ribavirin (RBV) management era. Methods Patients with chronic HCV attending GSH Liver Clinic from 2002 to 2014, were included, in the analysis. Relevant data were extracted from a registry and existing …
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Role of Gsh Metabolism In Mediating Stromal-Leukemia Interaction and Promoting Cell Survival and Drug Resistance In Chronic Lymphocytic Leukemia
… a significant decrease in cellular glutathione (GSH) and an increase in basal ROS levels. However, when cultured in the presence of bone marrow stromal cells, CLL cells restored their redox balance with an increased synthesis of GSH, a decrease in spontaneous apoptosis, and an improved cell …
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Look and Leep: How are we doing? An audit of GSH colposcopy clinic from 1 January 2017 to 31 December 2021
Background: Cervical cancer persists as the second most common cancer in women in developing countries. The prevalence of cervical cancer has markedly decreased in well developed nations, primarily attributed to the implementation of efficacious screening services. Such screening services pose …
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Implementation of Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy (HERMES) for quantification of ɣ-aminobutyric acid (GABA) and glutathione (GSH)
… of ɣ-aminobutyric acid (GABA) and glutathione (GSH) quantification. These metabolites, present at low concentrations in the brain, are challenging to detect using MR spectroscopy due to the fact that their resonance frequencies overlap with those of other more abundant metabolites. The advanced …
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An analysis of the CT and CT angiogram findings of methamphetamine induced stroke in young adults (≤45 years) presenting to GSH Emergency department
… in young adults (≤ 45 years) presenting to GSH emergency department. The recreational use of methamphetamine in the Republic of South Africa is on the rise accounting for 30% of patients admitted to addiction rehabilitation centres countrywide1 . In the Western Cape province alone …
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Pengaruh ekstrak daun pegagan (Centella asiatica (L.) urban) terhadap kadar antioksidan Superoksida Dismutase (SOD) dan Glutation Superoksida Hidroksil (GSH) pada ovarium mencit (Mus musculus)
… dengan peningkatan antioksidan enzimatis SOD dan GSH. SOD dan GSH berfungsi untuk perbaikan sel sehingga dapat menghambat pertumbuhan dan perkembangan folikel dalam ovarium. Keberadaan senyawa triterpenoid saponin dan fitosterol dalam pegagan dapat menyebabkan feedback negatif pada pelepasan …
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The outcomes of intravesical botox a injections in patients with refractory overactive bladder syndrome treated in GSH from 1 January 2016 to 31 December 2018
… has been offered at Groote Schuur Hospital (GSH) in South Africa since 2012. Therefore, a review of our outcomes is necessary. Objective: Primary: 1. Determine the subjective success following intravesical Botox injections for the treatment of OABS. Secondary: 1. Describe the population of …
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Glutathione regulation during exercise: Effect of fasting-refeeding, glutathione depletion and supplementation
Glutathione (GSH) is an important intracellular and extracellular antioxidant, critical for the organism's protection against reactive oxygen species. Since prolonged aerobic exercise has shown to increase formation of reactive oxygen species, this thesis investigated the importance of GSH during …
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Human glutathione S-transferases : characterization, tissue distribution and kinetic studies
… and acidic lung glutathione S-transferases (GSH S-T) was undertaken. Purification of the basic and near-neutral GSH S-T was achieved using a combination of affinity chromatography, chromatofocusing and immunoaffinity chromatography. Affinity and ion exchange chromatography were employed in …
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
… oxidative injury murine tumors depend upon the GSH oxidation-reduction cycle. The susceptibility of tumor cells to lysis by a flux of H<sub>2</sub>O<sub>2</sub>, such as generated by granulocytes or activated macrophages, or by the enzyme glucose oxidase, was augmented by interference with the …
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Structure/toxicity relationships and fate of low molecular weight peptide toxins from cyanobacteria
Hepatic glutathione (GSH) was depleted to assess the influence of GSH on the toxicity of MCYST-LR in vivo. The GSH conjugate of MCYST-LR was also formed synthetically. There was an approximately four-fold decrease in the toxicity of the GSH derivative, as compared to the parent toxin; but the GSH …
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The Phylogenetic Analysis Of Genes Encoding Specific Steps In The Glutathione Pathway Within Industrial Beer Brewing Strains: Saccharomyces Cerevisiae, Saccharomyces Pastorinus, And The Spoilage Microbe Brettanomyces
<p>The Glutathione pathway, (GSH) is an antioxidant system in yeast that increases cell viability and contributes to the production of desirable beer flavors during industrial fermentation. Despite its importance, studies using the GSH pathway: GSH1, GSH2, GLR1, and SOD1 genes, to trace the …
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The identification, purification and characterization of the fetal rat liver glutathione S-transferase isoenzyme YcYfetus
… expression of the glutathione S-transferases (GSH S-T) in fetal rat livers in order to provide more information about the role played by this important group of enzymes in the fetus. The study commenced with an examination of the subunit composition of adult and fetal rat liver GSH S-T using …
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Structural and Functional Analysis of Substrate Recognition and Inhibition of the Multidrug Transporters MRP1 and MRP2
… agents out of the cell in a glutathione (GSH)-dependent manner, the mechanism of GSH-dependent MRP1 substrate transport has previously not been understood. Additionally, over the past three decades, multiple small-molecule inhibitors of MRP1 transport have also been identified, with the …
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Glutathione metabolism of Plasmodium falciparum
… in the future. The tripeptide glutathione (GSH) or γ-glutamylcysteinyl-glycine is the most abundant low molecular weight thiol in most eukaryotic organisms and serves a number of important functions as sulfhydryl-buffer, cofactor for enzymes and for the detoxification of xenobiotics and …
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The Mechanism of Cyanohydroxybutene Induced Glutathione Elevation: The Role of Gamma-Glutamylcysteine Synthetase
… causes a 2- and 7-fold elevation in glutathione (GSH) in liver and pancreas, respectively. The mechanism of elevation is currently unknown. In an attempt to identify the mechanism of this GSH induction, the effect of CHB on hepatic and pancreatic $\gamma$-glutamylcysteine synthetase (GCS) …
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