Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"GSDMD"”.
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Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer
Gasdermin D (GSDMD) has recently been identified to play a central role in pyroptosis of monocytes, through its N-terminal effector domain cleaved by activated inflammatory caspases to form pores on cell membrane. However, as the universally expressed protein in cancer cells, its function beyond …
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Characterization of GSDMD as a Positive Regulator of Breast Cancer Cell Proliferation and Mammary Tumorigenesis
… in a variety of cancers. Interestingly, GSDMD, the most well-characterized member, has been reportedly overexpressed in BC. However, its role in tumorigenesis and underlying molecular mechanisms are unknown. In this study, we ascertained the protein and mRNA expression levels of GSDMD in …
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… activates caspase-4/1 in macrophage that cleaved GSDMD, the executioner of cell pyroptosis, leading to the insertion of N-terminal effector domain into the cell membrane, driving both pore formation and IL-1β secretion without causing significant cell death. In this study, I interrogated the …
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Inflammasomes in the Intestinal Epithelium
… this we have discovered a novel mechanism of GSDMD and propose that GSDMD regulates the activity of caspases in the intestinal epithelium. Together these data expand upon the knowledge of innate immune signalling in the human intestinal epithelium, enhancing our understanding of how …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… AIM2 inflammasome responses. Gasdermin D (GSDMD) is activated by caspase-1 to generate pores on the plasma membrane to induce pyroptosis downstream of the AIM2 inflammasome. We also demonstrated that mice lacking GSDMD were highly susceptible to <em>F. novicida </em>infection. …
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OROPOUCHE VIRUS DISRUPTION OF HOST CELL FUNCTIONS: PYROPTOSIS INDUCTION AND TRANSCRIPTIONAL SUPPRESSION
… and -8, leading to the cleavage of Gasdermin D (GSDMD) and Gasdermin E (GSDME), and the release of IL-1β. Furthermore, NLRP3-deficient macrophages fail to activate caspases, cleave Gasdermins, or produce IL-1β upon infection. These results indicate that OROV infection triggers NLRP3-mediated …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… oligomerization, IL-1 maturation, gasdermin-D (Gsdmd) cleavage, and pyroptosis upon bacterial infection. RNA-seq results unveiled that the ablation of Brd4 in BMDMs suppressed the transcription of Naips and Nlrc4. Mechanistically, ChIP-seq analysis revealed that Brd4 co-localized with Irf8 and …