Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 65 for “"GSC"”.
-
Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… homeodomain transcription factors Goosecoid (Gsc) and Mixl1. At the molecular level, Gsc has been described to function as a transcriptional repressor by directly binding to paired homedomain binding sites on target promoters. Here, I describe a novel mechanism of transcriptional repression by …
-
Characterization of Factors Controlling Germline Stem Cell Maintenance in Drosophila Melanogaster
… Drosophila oogenesis, a germline stem cell (GSC) divides asymmetrically to produce a renewed stem cell and a differentiated daughter cystoblast (CB) that will progress through the 14 stages of oogenesis to produce a mature egg. A myriad of factors regulate GSC maintenance; extrinsic signals …
-
REDOX HOMEOSTASIS IN THE DROSOPHILA TESTIS STEM CELL SELF-RENEWAL AND MAINTENANCE
… using the Drosophila testis germline stem cell (GSC) model. High ROS resulted in the activation of EGFR signaling, which functions to promote GSC differentiation, leading to a GSC loss. By contrast, low ROS caused an over-growth of GSC-like cells. To understand the mechanisms utilized by ROS to …
-
Broadband adaptive beamforming with low complexity and frequency invariant response
… for the generalised sidelobe canceller (GSC) structure. The GSC is an alternative implementation of the linearly constrained minimum variance beamformer, which can utilise well-known adaptive filtering algorithms, such as the least mean square (LMS) or the recursive least squares (RLS) to …
-
Smart Antennas at Handsets for the 3G Wideband CDMA Systems and Adaptive Low-Power Rake Combining Schemes
… propose a new generalized selection combining (GSC) method called minimum selection GSC (MS-GSC) and an adaptive rake combining scheme to reduce the power consumption of mobile rake receivers. The proposed MS-GSC selects a minimum number of branches as long as the combined SNR is maintained …
-
Transcriptional Integration of Wnt and Nodal Signals in the Establishment of the Spemann Organizer
… the promoter of the organizer gene Goosecoid (Gsc). Sia/Twn form homodimers and heterodimers through direct homeodomain interaction and both dimer forms are found at the endogenous Gsc promoter. The Gsc promoter also contains a Nodal responsive distal element, suggesting that Sia/Twn cooperate …
-
Neuro-Fuzzy Classification of Submarine Lava Flow Morphology On the Galapagos Spreading Center, 92W
… flow fields at the Galápagos Spreading Center (GSC). The maps are used to provide quantitative estimates of the abundance and spatial distribution of lava flow morphologies, which are used as a proxy for comparing average effusion rates within two study sites at the GSC with contrasting magma …
-
Adaptive Beamforming Using a Microphone Array for Hands-Free Telephony
… results, a generalized sidelobe canceler (GSC) is developed which incorporates a beamformer. The sidelobe canceler is evaluated using both NLMS and RLS adaptation. The RLS algorithm inherently gives better results than the NLMS algorithm, though the computational complexity renders the …
-
Combined Inhibition of Lysine-Specific Demethylase 1 and Kinase Signaling as a Preclinical Treatment Strategy in Glioblastoma
… their efficacy.</p> <p>Glioblastoma stem cell (GSC) lines and normal human astrocytes (NHAs) were treated with catalytic LSD1 inhibitors, NCD38 and bomedemstat, and the LSD1 scaffolding inhibitor, seclidemstat. Cells were treated with LSD1 inhibitors alone and in combination with kinase …
-
Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… by florid angiogenesis. Glioma stem cells (GSCs), enriched through CD133 (Prominin1) selection, are highly tumorigenic and therapy resistance. However, the mechanism through which GSCs promote tumor growth was largely unknown. As we noticed that tumors derived from GSCs contain widespread …
-
Regrowth of Festuca hallii (Vasey Piper) and Stipa curtiseta [(A.S. Hitch.) Barkworth] following defoliation on a hummocky landscape in Central Saskatchewan
… (A.S. Hitch.) Barkworth. Green standing crop (GSC), dead standing crop (DSC) and above ground net primary production (ANPP) were compared to an unmowed control after a single mowing in April, May, June, July, August, September, October or November on 5 landforms including north …
-
Atrx Inactivation and Idh1-R132H Drive Preferential Sensitivity to Proton Vs. X-Ray Radiotherapy In Glioma Stem Cells
… Glioma Stem Cells (GSCs) are self-renewable, treatment resistant cells in the glioma tumor mass known to promote tumor development. In contrast to traditional photon-based radiation therapy (XRT), proton radiation therapy (PRT) may induce more complex DNA damage and …
-
TO INVESTIGATE THE ROLE OF RNF8 IN REGULATING MITOTIC PROGRESSION IN GLIOMAS
… tumour that is driven by glioma stem cells (GSCs). The E3 ubiquitin ligase RNF8, an established DNA damage response factor, has been implicated in spindle assembly checkpoint (SAC) but its exact role remains unknown. Using RNF8 proximity proteomics, we find that RNF8 interacts with MAD2 and …
-
Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
… of cells frequently called glioma stem cells (GSCs). These cells are often resistant to conventional therapies, hence are the likely culprits of tumor recurrence. Here, we describe the derivation of a human GSC line, NNI-8. Our method preserves the karyotypic integrity of the primary tumor, and …
-
Towards the separation of linear α-olefins from industrial process streams using transition metal stationary phases
… was investigated. Gas solid chromatography (GSC) was found to be a quick and efficient technique for screening ion exchange resins and zeolites as potential support materials in olefin separation. Using GSC, the efficiency of Ag⁺ exchanged resin in retaining olefins relative to alkanes in a …
-
Identification of a novel autonomous role for Ecdysone Receptor during Drosophila ovarian germ cell differentiation
… the division of Drosophila germline stem cells (GSCs) and differentiation of their daughter cells to produce viable oocytes. The steroid hormone, ecdysone, is known to promote GSC self-renewal; however, due to lack of compatible genetic tools, potential autonomous roles in the germline have not …
-
Investigating the coordination of germline stem cell fate by ecdysone signaling and BMP signaling in the Drosophila ovary
Germline stem cells (GSCs) receive multiple secreted signals that regulate their fate. How these signals are integrated to balance self-renewal with differentiation are not well understood. Here, we use the Drosophila ovary as a model to understand how signal convergence is achieved. Ecdysone …
-
In vitro investigation of the effect of disulfiram on hypoxia induced NFκB, epithelial to mesenchymal transition and cancer stem cells in glioblastoma cell lines
… that hypoxia induces GBM stem-like-cells (GSCs), which are highly invasive and resistant to all chemotherapeutic agents, the detailed molecular pathways linking hypoxia, GSC traits and chemoresistance remain obscure. Evidence shows that hypoxia induces cancer stem cell phenotypes via …
-
Simulation and Mathematical Tools for Performance Analysis of Low-Complexity Receivers
… a sub-optimal generalized selection combining (GSC) diversity receiver over generalized fading channel models. The GSC receiver adaptively combines a subset of M diversity paths with the highest instantaneous signal-to-noise ratios (SNR) out of the total L available diversity paths. The …
-
The effects of graduated stimulus change on learning efficiency in a visual discrimination task
… indicated that graduated stimulus change (GSC) learners committed significantly fewer errors learning the discriminations and mastered significantly more of the training tasks presented than did trial-and-error learners. There was no significant difference between the two groups in the …
Page 1 of 4