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Showing 1 to 2 of 2 for “"GS-441524"”.
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DEVELOPING SMALL-MOLECULE PROBES AND INHIBITORS FOR ADP-RIBOSE-BINDING PROTEINS
… the tracer by incorporating the structure of GS-441524, an adenosine mimic known to bind SARS-CoV-2 Mac1. The optimized probes show hundreds to thousands-fold affinity increase for viral macrodomains, enabling cost-effective high-throughput screens. In Chapter 4, I constructed a focused …
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Great Expectations: Phosph(On)Ate Prodrugs In Drug Design—Opportunities and Limitations
… to the delivery of phosph(on)ate-containing drugs is their anionic character at physiological pH, which portends poor membrane permeability. This limitation has been successfully overcome through the use of prodrugs. When attached to the phosph(on)ate moiety, prodrugs mask the negative charge …