Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"GRPR"”.
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Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway
… express increased levels of GRP receptor (GRPR). Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, a crucial regulator of cell survival, is associated with poor outcome in neuroblastomas and our lab¡¦s previous work has shown that GRPR regulates the expression of PI3K/Akt …
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Molecular Mechanisms of Itch Sensations
… primitive. Gastrin-releasing peptide receptor: GRPR) was identified as the first itch-specific receptor in the spinal cord. GRPR cell ablation by bombesin-saporin abolished general scratching responses to pruritogens. Because GRPR mutant mice still have remained itch responses, it is possible …
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Exploring the role of Gastrin-Releasing Peptide Neurons in Circadian Time-Keeping of the Suprachiasmatic Nucleus
… and cells that express its cognate receptor (GRPR). Although implicated in retinal signalling into the SCN, its general role in the SCN is unknown. This thesis aims to determine the contributions to SCN time-keeping of not only GRP as a neuropeptide, but also of the neurons that release it …
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Radiolabeled Bombesin Analogs to Improve Prostate Cancer Diagnosis by PET Imaging
… du peptide de libération de la gastrine (GRPR) est un récepteur couplé aux protéines G. Ce récepteur est fortement exprimé dans le cancer de la prostate, il est ainsi un biomarqueur potentiel pour ce cancer. La bombésine est un peptide de 14 acides aminés qui se lie avec une forte affinité …
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From structural dynamics to drug repurposing: computational approaches in the context of precision medicine
… and the Gastrin-Releasing Peptide Receptor (GRPR) standing as highly promising candidates due to their overexpression in various cancers and diseases. Furthermore, the enzyme Cluster of Differentiation 38 (CD38), which is implicated in aggressive malignancies like myeloid leukemia, currently …
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Experimental determination of heat transfer and fluid flow over drift-emplaced canisters
… The data was valid for 150,000 {dollar}<{dollar} GrPr {dollar}<{dollar} 220,000. The results show that the heat transfer rates for natural convection from canisters in a cylindrical drift exceeded the case of long cylinders with no enclosures by 12% to 50%.
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Ανάπτυξη, βιοκατανομή και φαρμακοκινητική μελέτη πεπτιδικών αναλόγων μπομπεσίνης επισημασμένων με διαγνωστικά ραδιονουκλίδια για την αντιμετώπιση του καρκίνου
… γαστρίνης (gastrin-releasing peptide receptors, GRPrs), οι οποίοι υπερεκφράζονται στην επιφάνεια διαφόρων τύπων καρκινικών κυττάρων. Οι υποδοχείς GRP δυνητικά θα μπορούσαν να θεωρηθούν ιδανικός στόχος για την απεικόνιση νευροενδοκρινικών όγκων μετά από χορήγηση ραδιοεπισημασμένων παραγώγων ΒΝ, με …
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Identifizierung und Charakterisierung einer tumorentitätspezifisch überexprimierten Protein-Isoform eines bisher unbekannten Gens
… auf ein identifiziertes überexprimiertes Gen (GRPR), sind für die Gene bisher weder eine Funktion noch eine differentielle Expression detektiert worden. Aufgrund der signifikanten Überexpression in Lungen-Adenokarzinomen wurde das unbekannte Gen EST 5364 für eine nähere Charakterisierung …