Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"GRK3"”.
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Grk3 Connects Angiogenesis and Neuroendocrine Differentiation In Prostate Cancer By Activating Hdac2 That Epigenetically Represses Tsp1 and Rest
… found that G-protein coupled receptor kinase 3 (GRK3) is a critical regulator of both angiogenesis and neuroendocrine differentiation. GRK3 expression is pronouncedly elevated in NEPC tumors from GEM models and patients. GRK3 downregulates REST (the master repressor of neuronal genes) and TSP1 (a …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… another regulator of β-adrenergic signaling, GRK3 was recently shown to be a new critical regulator of prostate cancer progressionand tumor angiogenesis. However, mechanisms of GRK3 in prostate cancer progression and its regulation by ADRB2 signaling remain unknown.</p> <p>Our …
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Mechanisms Underlying the Adverse Consequences of Stress: A Role for the Dynorphin/Kappa Opioid Receptor System, p38α MAPK, and the Serotonin Transporter
… potentiation of drug reward is mediated by GRK3 and p38α MAPK in serotonergic neurons. These results support the hypothesis that stress-induced activation of the dynorphin/KOR system mediates the aversive component of stress to produce potentiation of drug reward. Finally, I investigated …
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Ligand Bias by the Endogenous Agonists of CCR7
… and b-arrestin2 recruitment catalyzed by both GRK3 and GRK6 while CCL21 activates GRK6 alone. This differential GRK activation leads to distinct functional consequences. Only CCL19 leads to the recruitment of b-arrestin2-GFP into endocytic vesicles and classical receptor desensitization. In …