Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"GRK"”.
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Identification of A Conserved Cluster In The Rh Domain of Grk Critical For Activation By Gpcrs
… of these receptors by GPCR kinases (GRK) is a major mechanism of desensitization. Considerable evidence from studies of rhodopsin kinase and GRK2 suggests there is an allosteric docking site for the receptor distinct from the GRK catalytic site. While the agonist-activated GPCR …
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Functional characterization of the role of Imp, a Drosophila mRNA binding protein, during oogenesis
… to regulate localized expression of gurken (grk). In addition, Imp binds grk mRNA with high affinity in vitro and is concentrated at the site of grk localization in midstage oocytes. Mutation of the Imp gene does not substantially alter grk expression, but does partially suppress the grk …
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Modelling Β2Ar Regulation
… SABA-induced G protein coupled receptor kinase (GRK)-mediated β2AR regulation; (ii) Three phenomenological models of salmeterol (a LABA)-induced GRK-mediated β2AR regulation; and (iii) One semi-quantitative, unified model of SABA-induced GRK-, protein kinase A (PKA)-, and phosphodiesterase …
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Ligand Bias by the Endogenous Agonists of CCR7
… by the G-protein coupled Receptor Kinase (GRK)/ b-arrestin system. CCL19 and CCL21 are endogenous agonists for the chemokine receptor CCR7. They are known to be equipotent in promoting Gi/o mediated calcium mobilization, chemotaxis and inhibition of adenylyl cyclase activity. Here we test …
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The Pure Virtual Braid Group is Quadratic
… ideal I, the associated graded algebra grK need not in general be quadratic: although it is generated in degree 1, its relations may not be generated by homogeneous relations of degree 2. In this thesis we give a sufficient criterion (called the PVH Criterion) for grK to be quadratic. …
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Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
… and 346) and G protein coupled receptor kinases (GRKs) (serines 355, 356 and 364), ubiquitination (lysines 348, 372 and 375) and palmitoylation (cysteine 341). However, the physiological role of these modifications on β2AR signaling regulation in the heart remains unclear. This study provides new …
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Internalisation of the type II gonadotropin-releasing hormone receptor of marmoset monkey
… of G protein-coupled receptor kinases (GRKs), dynamin-1 and β-arrestin 1 and 2 with the type II GnRH receptor. The results show that internatisation of the receptor requires GRK 2 and dynamin but does not require β-arrestin 1 and 2. Furthermore, inhibitors to both the caveolae pathway as …
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Molecular Regulation of Opioid Receptor Signaling
… involving G protein-coupled receptor kinase (GRK) and arrestin. Therefore, a partial KOR agonist that does not efficiently activate arrestin-dependent signaling may produce analgesia without dysphoria. No selective KOR partial agonists are currently available, and preclinical assessment is …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory diseases. However, the understanding of how RKIP expression level is regulated is poor. In this …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory diseases. However, the understanding of how RKIP expression level is regulated is poor. In this …
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Development of a Microplate-Based Calcium Assay for Studying Desensitization of the P2Y2 Nucleotide Receptor
… of the G protein-coupled receptor kinase (GRK) family and the β-arrestins. As GRK2 and β-arrestin-1 have been demonstrated to mediate P2Y2R desensitization in rat arterial smooth muscle cells, it was hypothesized that the human homologs would mediate P2Y2R desensitization in human 1321N1 …
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Rhodopsin kinase structure: different nucleotide-binding states and implications for mechanism of activation of a G protein coupled receptor kinase
G protein coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins and downregulation. The desensitization of GPCRs is critical to render cells responsive to further stimuli and if not regulated can result in many …
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The Structural and Functional Study of GIT1 Paxillin Binding Domain
<p>The G protein coupled receptor (GPCR)-kinase (GRK) interacting protein 1 (GIT1) is a multidomain protein that plays an important role in cell adhesion, motility, cytoskeletal remodeling, and membrane trafficking. GIT1 mediates the localization of p21-activated kinase (PAK) and PAK-interactive …
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Mechanisms of Exercise-Mediated Restoration of Renal Dopamine D1 Receptor Function in Aging
… to increase D1R serine-phosphorylation via PKC/GRK-2 pathway. This causes D1R G-protein uncoupling and the inability of D1R agonist SKF-38393 to inhibit Na, K-ATPase in RPTs and subsequently promote sodium excretion in old rats. Exercise improves physiological function and reduces mortality. …
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Identifizierung der für die Agonisten-induzierte Phosphorylierung und Internalisierung relevanten Serine und Threonine in der C-terminalen Domäne des humanen Prostaglandin E2 Rezeptors, Subtyp EP4
… eine G-Protein-gekoppelter Rezeptor-Kinasen (GRK) vermittelte Phosphorylierung des Rezeptors an Serinen und Threoninen in den intrazellulären Domänen initiiert. Nach der Phosphorylierung kommt es zur Bindung des phosphorylierten Rezeptors an beta-Arrestin, was zu einer sterischen Inhibition …
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Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion
… auch durch G-Protein-gekoppelte Rezeptorkinasen (GRKs) phosphoryliert wird. Der Nachweis der Phosphorylierung nicht Ligand-gebundener Rezeptoren durch GRKs widerlegt das bisher gültige Konzept der heterologen Rezeptorregulation ausschließlich durch second-messenger -aktivierte Kinasen wie PKC und …
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Studies of Smoothened in Hedgehog Signaling Pathway
… that Gprk2, a G protein coupled receptor kinase (GRK), plays a positive role in regulating Hh signalling. I provided evidence that Gprk2 interacts with Smo Ctail. Furthermore, I identified a new CKI phosphorylation cluster that appears to be critical for Smo endocytosis and activation.
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NOVEL ROLES FOR GRK2 IN METABOLIC HOMEOSTASIS AND SKELETAL MUSCLE PHYSIOLOGY
… of G protein-coupled receptor kinase 2 (GRK2) in the physiology and pathophysiology of the heart. Adrenergic receptors are the primary target for GRK2 activity in the heart; phosphorylation by GRK2 leads to desensitization of these receptors. As such, levels of GRK2 activity in the heart …