Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"GREMLIN"”.
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GREMLIN: GOES radar estimation via machine learning to inform NWP
… Rapid Refresh (RAP/HRRR). Development of the GREMLIN (GOES Radar Estimation via Machine Learning to Inform NWP) convolutional neural network (CNN) will be described. This includes the creation of a hierarchy of open source datasets, and will emphasize the importance of the neural network loss …
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An Investigative Study Into the Relationship of Bone Morphogenetic Protein Antagonist Expression and Osteocyte Density by Region and Quadrant
… mice were immunohistochemically stained for gremlin and noggin expression and also underwent methyl green staining to determine osteocyte presence. Bone sections were divided into four quadrants (cranial, caudal, medial and lateral) and three regions (proximal, mid shaft and distal), followed …
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Effects of early nutrition on the wnt and bone morphogenic protein pathways in the developing intestine
… sFRP3, sFRP4, frizzled 6, DKK1 (Wnt pathway), gremlin (BMP pathway), TNF-a, HNF-4α and osteopontin (OPN) was measured by RT-qPCR. Piglets fed the F+P diet had greater acetate concentration and lower pH in the ileum at day 14 and in the colon at day 7 and day 14 than F piglets. Butyrate …
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Protein structure determination using evolutionary information
… limitation of the method, we applied our method (GREMLIN) to predict residue-residue level interactions between proteins and within a protein. These contacts were used to predict the structure of 58 protein families and complexes. Nine of these structures have since been determined with …
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Geotemporal Dreams (or, the Prophet)
… specifics still to be determined, and the Full Gremlin ensemble has been secured for this performance.
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Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
… is altered in IBD for as yet unknown reasons. Gremlin 1+ (Grem1) Mesenchymal Stromal progenitor Cells (MSCs) are progenitors of CMFs under homeostasis, but their fate during IBD immunopathogenesis is unknown. I hypothesize that PD-L1 expressed by CMFs is a critical driver of immune imbalance in …
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Limbs gone batty : the role of the anterior-posterior patterning signal, Sonic Hedgehog, in the development of the unique bat limb
… parallel the reported up-regulation of Fgf8, Gremlin and Bmp2 in the interdigital tissue of C. perspicillata (Weatherbee et al. 2006) and support the hypothesis that the Shh-Fgfpositive feedback loop is re-initiated in the interdigital tissue of the bat limbs. The cell survival and …
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Specific forms of TCF7L2 protein define the Wnt pathway dependent genetic program
… organoid media growth factors, R-spondin1 and Gremlin-1, that were produced from bacterial expression and optimised for organoid culture. I further investigated whether R-spondin1 could be further engineered to increase its potency in organoid growth media. My strategy was to introduce …
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The Role of Gremlin1 in Multiple Myeloma
… defined. The studies presented here show that Gremlin1 (Grem1), a highly conserved protein, which is abundantly secreted by a subset of BM mesenchymal stromal cells, plays a critical role in MM disease development. We describe, for the first time, a novel positive feedback loop between MM PCs …
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Nucleosome-independent permanently condensed chromosome: investigation of novel nuclear organisation in the dinoflagellates
Dinoflagellates hold vast diversities and are major contributors to overall marine primary production. Close relatives to the apicomplexan parasites and ciliates, the dinoflagellates, however, have a shockingly different nuclear biology. The dinoflagellates have massively inflated genomes (2-245 …