Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"GREM1"”.
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Elucidating the role of Gremlin1 in colorectal cancer
Gremlin1 (GREM1) is a secreted bone morphogenetic protein (BMP) antagonist, involved in many biological processes, including organogenesis and tissue differentiation. Consequently, GREM1 dysregulation is implicated in many human diseases such as diabetic nephropathy, pulmonary hypertension and …
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The Role of Gremlin1 in Multiple Myeloma
… The studies presented here show that Gremlin1 (Grem1), a highly conserved protein, which is abundantly secreted by a subset of BM mesenchymal stromal cells, plays a critical role in MM disease development. We describe, for the first time, a novel positive feedback loop between MM PCs and BM …
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Interpreting transcriptional signatures and their relevance to disease biology, prognosis and treatment resistance in colorectal cancer
… DGEA was also performed to determine the role of GREM1 expression in drug resistance. Hierarchical clustering was used throughout the course of this project using the Partek Genomics Suite software. Additionally, Kaplan-Meier curves were also employed for survival analysis and boxplots were used …
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Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
… in IBD for as yet unknown reasons. Gremlin 1+ (Grem1) Mesenchymal Stromal progenitor Cells (MSCs) are progenitors of CMFs under homeostasis, but their fate during IBD immunopathogenesis is unknown. I hypothesize that PD-L1 expressed by CMFs is a critical driver of immune imbalance in IBD and …