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Showing 1 to 3 of 3 for “"GQ Structure"”.
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Structural characterization of G-Quadruplexes within duplex DNA
The G-Quadruplex (GQ) is a repetitive, guanine rich DNA sequence that occurs throughout the genome. This specific DNA motif is capable of forming an alternative DNA secondary structure similar to a rectangular prism. The most common GQ motif consists of four sets of three guanine bases separated by …
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Exploring the Forces Underlying the Dynamics and Energetics of G-quadruplexes with Polarizable Molecular Dynamics Simulations
G-quadruplexes (GQs) are highly stable noncanonical nucleic acid structures that form in the DNA of human cells and play fundamental roles in maintaining genomic stability and regulating gene expression. These unique structures exert broad influence over biologically important processes and can …
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Single molecule studies of helicase mechanisms
… to preferentially bind to non-canonical DNA structures such as G-quadruplexes and Holliday junctions. Ensemble biochemical research has shown that BLM probably has roles in the maintenance of genome integrity by disrupting non-canonical DNA structures and migrating Holliday junctions to allow …