Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"GQ"”.
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Celebrities at Work: The Symbolic Production of Masculinities in American & British GQ Magazines in 2012
… of the 2012 editions of American and British GQ magazines. Men’s lifestyle magazines, such as GQ, are influential in helping readers make sense of themselves through representations of celebrity, fashion and style. Although the magazine began as a men’s fashion publication, contemporary …
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An analysis of linguistic features of male cosmetics advertisements from FHM (For Him) and GQ (Gentlemen's Quarterly) magazines
… advertisements. Thirty advertisements from the GQ (Gentlemen’s Quarterly) and FHM (For Him Magazine) magazines of 2015 were analysed for persuasive features. These two magazines were chosen because they are typical male magazines focusing on entertainment, travel, sex, sports and fashion. This …
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The rise of the ‘new’ lad in men’s lifestyle magazines : an analysis of GQ front covers throughout the last five decades
… with how a particular men’s lifestyle magazine, GQ, has changed its way of representing masculine identity through the last five decades. By studying the design as well as the content of the magazine front covers, a semiotic analysis is carried out in order to reveal these changes which have led …
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Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long Term Depression That Is Affected in Fragile X Syndrome
Activation of Gq-coupled group I metabotropic glutamate receptors (mGluR1, mGluR5) induces long-term synaptic depression (LTD) that requires rapid, dendritic protein synthesis. The significance of protein synthesis-dependent mGluR LTD to cognitive function is highlighted by the recent finding that …
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Structural characterization of G-Quadruplexes within duplex DNA
The G-Quadruplex (GQ) is a repetitive, guanine rich DNA sequence that occurs throughout the genome. This specific DNA motif is capable of forming an alternative DNA secondary structure similar to a rectangular prism. The most common GQ motif consists of four sets of three guanine bases separated by …
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Polarizable Simulations of the bcl-2 DNA G-Quadruplex and FMRP RNA G-Quadruplex:Duplex Junction Binding Protein
A G-quadruplex (GQ) is a type of noncanonical nucleic acid structure that can form in regions of nucleic acids rich in guanine nucleotides. The guanine bases form a square planar conformation via Hoogsteen hydrogen bonding. These stacked tetrads have inward-facing carbonyl oxygens, facilitating the …
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Determinação Quantitativa de um Derivado Tiazolidínico (3-(2-bromo-benzil)-5-(5-bromo-2-metoxi-benzilideno)-tiazolidina-2,4-diona) em Plasma de Ratos Wistar: Desenvolvimento e Validação de um Método Analítico Recife
… -metoxi-benzilideno)-tiazolidina-2,4-diona) (LPSF/GQ-113B) apresentou importante atividade antiinflamatória em ratos Wistar. Tal resultado despertou nosso interesse no desenvolvimento e validação de um método bioanalítco para determinação do LPSF/GQ-113B em fluídos biológicos. Nesse contexto, um …
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Computer-Aided Drug Design of G-quadruplex Structures: Harnessing Polarization for Rational Drug Design
G-quadruplexes (GQs) are noncanonical nucleic acid structures formed by guanine-rich se- quences that adopt stable, planar arrangements of guanines stabilized by Hoogsteen hydro- gen bonding. These structures are found throughout the human genome and in numerous pathogens, including viruses and …
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Exploring the Forces Underlying the Dynamics and Energetics of G-quadruplexes with Polarizable Molecular Dynamics Simulations
G-quadruplexes (GQs) are highly stable noncanonical nucleic acid structures that form in the DNA of human cells and play fundamental roles in maintaining genomic stability and regulating gene expression. These unique structures exert broad influence over biologically important processes and can …
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Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor
… receptor regulates reproduction by activation of Gq/11 proteins. In contrast, GnRH receptors at extrapituitary sites induce anti-proliferative effects that do not correlate with Gq/11 activation. We propose that the two endogenous ligands, GnRH I and GnRH II, and certain antagonists selectively …
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Effect of oxidative stress on human telomeric DNA structural dynamics and accessibility
… (ssTEL) that can form into a G-quadruplex (GQ). This guanine-rich sequence is prone to 8-oxoguanine (8OG) damage, which is one of the most common oxidative DNA lesions that can compromise telomere integrity. Here, we use single molecule Förster Resonance Energy Transfer (smFRET) to …
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Structural Dynamics and Electrostatic Properties of the VEGF and PIM-1 Oncogenic Promoter G-Quadruplexes from Polarizable Molecular Dynamics Simulations
G-Quadruplexes (GQs) are higher ordered nucleic acid structures that form within regions of DNA and RNA that are enriched with guanine nucleobases. These structures are highly stable and have been shown to function in genomic maintenance and regulating key biological processes. Due to their role in …
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Information theoretic and machine learning techniques for emerging genomic data analysis
… four-stranded structure called ""G-quadruplex"" (GQ). GQ structures have been proposed to regulate diverse key biological processes including transcription, replication, and translation. I present main factors that lead to GQ formation, and propose highly accurate linear regression and Gaussian …
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Gaussian Quadrature for computer aided robust design
… supplanted Monte Carlo. Gaussian Quadrature (GQ) is presented here as a new option with significant benefits for many types of engineering problems. Advantages of GQ include: as few as 2*(number of noise factors) simulation runs required to estimate performance mean and variance, errors …
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Double spin asymmetry AL̳T̳ in charged pion production from deep inelastic scattering on a transversely polarized ³He target
… momentum dependent parton distribution function gq/1T, which describes the longitudinal polarization of quarks in a transversely polarized nucleon. The gq/1T function requires an interference between wave function components differing by one unit of quark OAM, and therefore provide access to …
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Dissection of GnRH receptor-G protein coupling
… (GPCR) on pituitary gonadotropes and activates Gq/11-mediated signalling pathways to stimulate the biosynthesis and the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH). Both GnRHs have also been suggested to inhibit cellular proliferation, an action which has largely …
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Síntese, comprovação estrutural e atividade antiinflamatória de compostos tiazolidinônicos - 3, 5 - dissubstituídos
… das séries químicas LPSF/GQ e LPSF/SF, obtidos a partir da reação de adição de Michael entre a 3-(4-metil-benzil)-tiazolidina-2,4-diona (LPSF/GQ-1) ou a 3-(4-nitro-benzil)tiazolidina-2,4-diona (LPSF/SF-1) com derivados 3- aril-2-ciano-acrilatos de etila substituídos …
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A prospective investigation of joy and trait gratitude
… done with university students taking the GRAT, GQ-6, and measures of joy at two time points, seven to nine weeks apart. Data were analyzed from 149 participants recruited from psychology classes. Participants with higher trait gratitude at Time 1, as determined by the GRAT, tended to have more …
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K-theoretic Hall algebras for quivers with potential
… half of the Yangian Y[subscript MO]([subscript gQ]). The goal of this thesis is to extend these ideas to K-theory. More precisely, we construct a K-theoretic Hall algebra using category of singularities, define a filtration whose associated graded algebra is a deformation of a symmetric algebra, …
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Biased Constitutive Activity in the Uveal Melanoma Oncogene CYSLTR2 is Unique in CYSLTR2 Germline and Pan-Cancer Human Variome
… of CysLTR2-L129Q. CysLTR2 signals through the Gq/11/PLC-β pathways, so using a homogenous time resolved fluorescence (HTRF) IP1 accumulation assay, we show that CysLTR2-L129Q is a constitutively active mutant that strongly drives Gq/11 signaling pathways. However, CysLTR2-L129Q only poorly …
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