Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"GPVI"”.
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NOVEL REGULATORS OF GPVI-MEDIATED PLATELET ACTIVATION
… sub-endothelial collagen is Glycoprotein VI (GPVI). The activation of platelets leads to platelet shape change, granular secretion, thromboxane A2 (TXA2) synthesis, and integrin IIb3-mediated platelet aggregation and thrombus formation. In the past, a lot of effort has been placed in …
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Regulation of Syk activity in GPVI-mediated platelet activation
… is initiated, mediated by Glycoprotein VI (GPVI), which results in platelet activation. A major signaling protein in GPVI signaling is Spleen tyrosine kinase (Syk). It undergoes phosphorylation and activation following GPVI stimulation. Syk's central role in this physiological process …
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Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins
GPVI activates platelets through an ITAM pathway by activation of Src and Syk kinases leading to activation of PLC\(_y\)2. CLEC-2 has been shown to activate platelets using an ITAM-like sequence in its cytoplasmic tail that is also dependent on Src and Syk kinases, but shows a partial rather than …
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CD148: a positive regulator of GPVI and \(\alpha\)II\(\beta\)3 proximal signalling in platelets
… from the main collagen activation receptor GPVI and the fibrinogen integrin \(\alpha\)II\(\beta\)3, and also plays a minor role in regulating thrombin and thromboxane A\(_\\) (TxA\(_2\) mediated aggregation and secretion via the PAR-4 and TP receptors, respectively. The molecular mechanism …
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In vitro and in vivo studies on the activating platelet collagen receptor glycoprotein VI in mice
… target. The first mAb against (mouse) GPVI, JAQ1, was generated and used to demonstrate that GPVI requires the FcRgamma-chain for its expression and function and that this receptor is the central molecule in collagen-induced platelet activation. Blocking the major collagen binding site …
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Cellular regulation of platelet glycoprotein VI : in vivo and in vitro studies in mice
… major collagen receptor on the platelet surface, GPVI. The work presented here focused on studying the cellular regulation of GPVI. In addition, a possible role for GPVI in thrombus formation induced by atherosclerotic plaque material was investigated and it was found that GPVI plays an important …
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Platelet Receptor Glycoprotein VI in Ischaemic Stroke
… The work in this thesis demonstrates that GPVI-dimer binds to fibrin also, causing platelet activation through a mechanism independent of collagen. In ischaemic stroke this is important as it not only implicates GPVI-dimer in the large-artery atherosclerotic stroke subtype, it suggests a …
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The Evolution of Platelet Responses to Collagen Under Conditions of Hemodynamic Flow
… activates platelets through the immune-type GPVI receptor, but the mechanism by which this receptor has adapted to function in platelets under conditions of rapid blood flow is unclear. Additionally, it is unknown if responses to collagen are conserved in nucleated thrombocytes found in …
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Molecular Mechanisms Underlying Differential Regulation of Platelet Dense Granule Secretion by Protein Kinase C delta
… receptors (PAR)s and glycoprotein VI (GPVI) receptors. We evaluated the role of PKCδ in platelets using two approaches - pharmacological and molecular genetic approach. In human platelets pretreated with isoform selective antagonistic RACK peptide (δV1-1)TAT, and in the murine platelets …
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Platelet surface receptors and melanoma metastasis
… war es, die Rollen der Plättchen-Rezeptoren GPVI und GPIbα bei der hämatogenen Melanom-Metastasierung zu untersuchen. Die letzten Jahrzehnte haben zunehmend Indizien für eine Beteiligung von Plättchen und Plättchen-Rezeptoren bei der hämatogenen Tumor-Metastasierung geliefert. Man weiß heute, …
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The Regulation of Phosphorylation Events in Platelets
… of platelet surface receptor Glycoprotein VI (GPVI) to exposed collagen initiates a signaling cascade, which culminates in platelet activation. Stimulation of GPVI pathways results in the generation of thromboxane and causes the platelets to secrete their granule contents. This generated …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… Soluble biomarkers, including soluble (s) GPVI, thrombopoietin, and citrullinated histone-DNA complexes, were elevated in patients with bleeding. Integrin aIIbb3 activation remained functional but viscoelastic assays showed significantly impaired clot formation parameters. The 'platelet …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… that fucoidan was not acting primarily through GPVI receptor. On the other hand, fucoidan-induced platelet activation was inhibited in platelet-specific CLEC-2 knock-out murine platelets revealing CLEC-2 as a physiological target of fucoidan. Thus, our data show fucoidan as a novel CLEC-2 …
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Adiponectin : a novel circulating anti-thrombotic factor in humans?
… conditions was inhibited by the glycoprotein VI (GPVI) blocking antibody, 10B12, but not ethylene glycol-bis (β-aminoethyl ether)-N,N,N’,N’,-tetraacetic acid (EGTA), suggesting a GPVI-dependent and integrin-independent mechanism.Together these data significantly improve our understanding of the …
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The role of platelets and their associated recruitment mechanisms, in intestinal ischaemia reperfusion injury
… platelets following intestinal IR injury, namely GPVI, GPIb-IX-V and the integrins IIb3 and 21. Intravital microscopy was utilised to monitor individual platelet adhesion and microthrombus formation in anaesthetised mice undergoing intestinal IR injury \(in\) \(vivo\) using a novel dual labelling …
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Characterization of the Tetraspanin protein Tspan18
… signalling by the platelet collagen receptor GPVI. Finally, Tspan18 mRNA was found to be relatively highly expressed in endothelial cells and peripheral blood leukocytes. Together these data suggest a role for Tspan18 in calcium signalling on these cell types.
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… and plays an important role downstream of GPVI-FcR gamma chain receptor complex activation. We studied the effects of curcumin (diferuloylmethane), which is the active ingredient found in the herbal remedy and food spice turmeric, on the GPVI-mediated platelet activation. We have found that …
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Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins
… because the platelet collagen receptor, GPVI, was unaffected. Similar to dectin-1, CLEC-2 signalling in response to its ligand, the snake venom toxin rhodocytin, was also abrogated following tetraspanin over-expression. However, stable tetraspanin over-expression only partially reduced …
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Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram
… early protein phosphorylation within the GPVI pathway, resulting in the inhibition of subsequent platelet responses. Further experiments show that other commonly used antidepressants also inhibit platelets. As with citalopram, inhibition was only observed at concentrations above those …
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A Microfluidic Approach For Investigating The Role Of Blood Flow In Thrombosis
… is more important in SIPA than VWF stretching. GPVI-bound soluble fibrin inhibits platelet activation by collagen. Developing new microfluidic models of thrombosis may lead to a better understanding of the mechanisms involved and produce diagnostic tests for thrombotic diseases.
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