Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"GPR65"”.
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The role of GPR65 and GALC in Multiple Sclerosis: Establishing the functional consequences of an MS associated variant on chromosome 14q31.3
… surface receptor G-protein coupled receptor 65 (GPR65). In my thesis I attempted to validate and replicate this finding, and also to explore the possibility of other pH dependent effects of this SNP. In order to undertake this work, I first developed a system capable of maintain cultured cells at …
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Proton-sensing G protein-coupled receptor signalling in inflammation
… and intracellular trafficking of the PS-GPCR GPR65 was interrogated in response to stimulation with protons as well as two other reported agonists. These studies highlighted that a synthetic agonist (BTB09089), with higher selectivity for GPR65 over other PS-GPCRs, was able to recapitulate …
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THE EFFECTS OF ACIDOSIS ON SURVIVAL PATHWAYS IN LYMPHOID MALIGNANCIES
… of the acid-sensing G protein-coupled receptor GPR65, an oncogene found to be expressed in a number of human cancers. Additional studies on the regulation of pro-apoptotic Bcl-2 family members led to the discovery that acidosis blocks a pro-apoptotic function of c-Jun to elevate PUMA expression. …