Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"GPR55"”.
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Profiling the activity of GPR55 antagonists against recombinant and endogenous GPR55
GPR55 is a putative novel cannabinoid receptor that is capable of being activated by a subset of cannabinoid ligands and the endogenous lipid, L-α-lysophosphatidylinositol (LPI). GPR55 mRNA is expressed widely throughout the body, particularly in the brain, bone and immune tissue, and is also …
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GPR55 and N-acyl Amino Acids
<p>G-protein coupled receptor 55 (GPR55) is a novel lipid sensing receptor activated by the endogenous lipid, lysophosphatidylinositol (LPI) and is reported as a putative cannabinoid receptor. However GPR55 shares limited homology with the two cloned cannabinoid receptors (CB<sub>1</sub> and …
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Studies on the role of GPR55 in cardiovascular physiology and pathophysiology.
… the role of G-protein-coupled receptor 55 (GPR55) in atherosclerosis reported conflicting results; one reported a pro-atherogenic role for GPR55 and the other, an anti-atherogenic role for this receptor. Interestingly, another study demonstrated that the activation of GPR55 by …
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Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences.
… coupled receptor-55/Lysophosphatidylinositol (GPR55/LPI). Despite being upregulated in the setting of obesity, the function of GPR55 in obesity and other disease states remains elusive. Therefore, the present study aimed to 1) investigate the role of GPR55 in obesity by characterising the …
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Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol.
… the CB1 and CB2 receptors and an antagonist of GPR55. Moreover, is has been shown to reduce infarct size and ameliorate reductions in left ventricular function in vivo. These improvements in the pathogenesis of experimental MI are accompanied by a reduction in inflammatory cell migration to the …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… receptor G-protein coupled receptor 55 (GPR55) in a tissue specific manner. Renal expression and function of these receptors, particularly within the pathophysiological context of obesity and diabetes related renal damage is poorly understood. The research presented in this thesis …
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The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.
… 2 (CB1 and CB2), G protein-coupled receptor 55 (GPR55), G protein-coupled receptor 18 (GPR18), transient receptor potential vanilloid 1 (TRPV1) and peroxisome proliferator activated receptor alpha, delta and gamma (PPARalpha, delta and gamma) were expressed by OA chondrocytes and osteocytes in …