Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"GPR43"”.
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Investigation of the function, pharmacology and oligomerisation of GPR40, GPR41 and GPR43
GPR40, GPR41 and GPR43 are a small family of GPCRs. Fatty acids were identified as the ligands for these receptors in 2003. High levels of circulating fatty acids have been linked to a variety of diseases, including type 2 diabetes mellitus, cancer, and high levels of fatty acids are produced by …
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The Role of Adipose-Specific Free Fatty Acid Receptor 2 in Obesity and Associated Metabolic Dysfunction
… dysfunction. Free Fatty Acid Receptor 2 (FFA2/GPR43) has emerged as a potential modulator of adipocyte function, inflammation, and metabolism. To investigate the role of FFA2 expressed in the adipose tissue, we generated adipose-specific FFA2 knockout mice (Adipoq-F2-KO) and assessed metabolic …
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The Role of Short-Chain Fatty Acids on Intestinal Epithelial Cell Migration
… in a histone deacetylase inhibition (HDACi) and GPR43 dependent manner allows for further targeting of these pathways to circumvent some of the current pitfalls of SCFAs, mainly their ability to inhibit epithelial proliferation, which could be detrimental to ulcer healing.
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Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
… mediated by orphan G-protein receptors GPR41 and GPR43. S. typhimurium induced SPRR2 in undifferentiated cells. We conclude that SPRR2 protein expression is associated with differentiated epithelia and is regulated by PKA signaling and by by-products of the bowel flora. This is the first report to …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… To examine this, we silenced the SCFA receptor GPR43 and the bitter taste receptor T2R38 and revealed that butyrate no longer had the capacity to stimulate increased proglucagon abundance. Additionally, we also examined the abundance of SCFA transporters and noted increases in SLC5A8 in the …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… To examine this, we silenced the SCFA receptor GPR43 and the bitter taste receptor T2R38 and revealed that butyrate no longer had the capacity to stimulate increased proglucagon abundance. Additionally, we also examined the abundance of SCFA transporters and noted increases in SLC5A8 in the …
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Short Chain Fatty Acids Signaling through the G Protein-Coupled Receptor GPR41 in the Intestine.
… G protein-coupled receptors (GPCRs), Gpr41 and Gpr43. We show that Gpr41 is expressed in the intestinal enteroendocrine cells. The localization of Gpr41 to enteroendocrine cells suggests that SCFAs signaling through Gpr41 induces the enteroendocrine cells to release a soluble mediator. In this …
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Molekulare und histologische Untersuchungen zur gustatorischen Fettwahrnehmung des Menschen
… an kurz- bis langkettigen Fettsäuren abdecken (GPR43, GPR84, GPR120, CD36, KCNA5). Ein zweifelsfreier Nachweis des Proteins konnte für den auf langkettige Fettsäuren spezialisierten Rezeptor GPR120 in Typ-I- und Typ-III-Geschmackszellen der Wallpapillen erbracht werden. Etwa 85 % dieser …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
Obesity is linked to increased intestinal permeability that may contribute to low grade inflammation. Fructan prebiotics have been demonstrated to increase intestinal resistance and decrease systemic inflammation. The objective of this study was to test the effects of prebiotics on intestinal …