Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"GPR40"”.
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Investigation of the function, pharmacology and oligomerisation of GPR40, GPR41 and GPR43
GPR40, GPR41 and GPR43 are a small family of GPCRs. Fatty acids were identified as the ligands for these receptors in 2003. High levels of circulating fatty acids have been linked to a variety of diseases, including type 2 diabetes mellitus, cancer, and high levels of fatty acids are produced by …
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The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion
… T2D and obesity. Our initial characterization of GPR40 identified it as a receptor for medium- to long-chain free fatty acids (FFAs). With a marked expression in pancreatic beta-cell lines, we expected GPR40 to be involved in FFA-mediated augmentation of insulin release. This was confirmed when we …
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Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
… that the G-protein coupled receptor 40 (GPR40) is a functional FFA receptor expressed in pancreatic islets. We now show that both the acute stimulatory action of palmitate on IP3-generation, increased [Ca2+]i and insulin release as well as the long-term effects of palmitate on the …
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Nutritional modulation of the transcriptome in adipose, liver, and polymorphonuclear leukocytes in peripartal dairy cows
… for four GPCRs: G-protein coupled receptor 40 (GPR40), G-protein coupled receptor 120 (GPR120), G-protein coupled receptor 84 (GPR84), and G-protein coupled receptor 109A (GPR109A, also known as hydroxycarboxylic acid receptor 2/3, HCAR2/3), throughout the transition period (-10, +7, and +20 or …
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The impact of glucotoxicity on pancreatic β-cell function
… in the absence of hyperlipidemia almost abolish GPR40 expression in the islet cells and abrogate the FFA-induced secretory effects. We suggest that this might be an important contributing factor for dysfunction of β-cells seen in human type 2 diabetes (T2D). Furthermore we also observed that …
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Phenotypic analysis of human stem cells and their differentiation potential towards pancreatic cells
… and Oct-4. Several CB-HSCs expressed SOX-17, GPR40, and Nestin. ASCs expressed SOX-17, in addition to the characteristic ASC stem cell markers CD29 and CD90. The expression of pancreatic markers by undifferentiated HASCs, CB-HSCs, and ASCs indicates they could have the potential to …