Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"GPR35"”.
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Regulation of Visceral Nociception by GPR35
… for the development of new visceral analgesics. GPR35 is a G- protein-coupled receptor (GPCR) which preferentially signals through the activation of G<sub>αi/o</sub> subunits. GPR35 is designated as an “orphan” GPCR due to the ambiguity of its cognate ligand. However, a few synthetic (e.g., …
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Elucidating the biology of G-protein coupled receptor 35
G-protein coupled receptor 35 (GPR35) is an orphan G-protein coupled receptor which has attracted attention as a coding variant is linked to primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). GPR35 is also upregulated in numerous cancers. Multiple studies of GPR35 have so far fallen …
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Harnessing Deep Learning with Protein Language Models to Unveil Microbial Enzyme Function in Health and Disease
… McbB is hypothesised to synthesise ligands for GPR35, a receptor genetically linked to IBD. These discoveries, facilitated by deep learning tools, could offer new insights into IBD pathology and lead to novel therapeutic targets. In the third chapter I detail the development of CAZyLingua, the …