Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"GPR30"”.
-
Exploring the metabolic role of GPR30 in mice
Recent studies showed that GPR30, a seven-transmembrane G protein-coupled receptor, is a novel estrogen receptor (ER) that mediates some biological events elicited by estrogen in several types of cancer cells. However, its physiological or pathological role in vivo is unclear. For the first project …
-
GPR30: a role for a novel estrogen-sensing receptor in hippocampal function?
… estrogen-sensing G protein coupled receptor (GPR30) was identified, and hippocampal expression of GPR30 indicates a potential role for this receptor in modulating hippocampal function. <br/>Thus, the primary aims of this thesis were to clarify the effects of E2 on glutamatergic synaptic …
-
The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… is dedicated solely to one particular GPCR, GPR30. This receptor is shrouded in uncertainty with contradictory results and opposing views on effectors and subcellular localization. The aim of this thesis was to elucidate the signaling and membrane trafficking of GPR30 in addition to look for …
-
Estrogen Signaling in Trigeminal Nociception
… pathways. The novel estrogen receptor GPR30 (G-protein coupled receptor 30) activates mediators of signal transduction, including ERK. A goal of this study was to determine which estrogen receptor is required for behavioral sensitization. In order to determine whether GPR30 is present …
-
The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis.
… G-1, a specific agonist to the membrane receptor GPR30. These results strongly suggest that the response to estradiol involved GPR30, but not ERalpha or ERbeta. Seven ovarian cancer cell lines and 44 ovarian tumor tissue samples expressed GPR30 mRNA. Expression was lower in poorly differentiated …
-
The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… that PC12 cells express membrane ER¥á, ER©¬, GPR30, and the DAT, and that a two day NGF-©¬ treatment increased the levels of DAT and ER¥á. Low concentrations (10-14-10-8M) of E2 administered for 9 minutes caused DA efflux, which was not dependent on extracellular Ca2+-mediated exocytotic …
-
The Identification and Characterization of Estrogen Receptors in the Mouse and Human Lens and Their Role in Cataract Development
… and mRNA expression of ERalpha, ERbeta, and GPR30 were examined in the mouse and human lens; 2) to determine if the loss of ERalpha and/or ERbeta receptors will induce spontaneous development of cataracts and to examine their role in an inducible cataract model; and 3) to identify …
-
The direct effects of estradiol and several xenoestrogens on cell numbers of early- vs. late-stage prostate cancer cells
… D1 levels in LAPC-4 cells. However, ERβ and GPR30 mediated these responses in PC-3 cells. Apoptosis was initiated in LAPC-4 and PC-3 cells by E2 only, and not by DES. Necroptosis was not altered by estrogens in either cell line. We showed for the first time the presence of mERs in both early …
-
Protective role of lignan-converting bacteria on chemically-induced breast cancer in gnotobiotic rats
… (ERα and ERβ) and G-coupled protein receptor 30 (GPR30). Similar findings were observed for both insulin-like growth factor 1 (IGF-1) and epidermal growth factor receptor (EGFR) genes involved in tumor growth. Proteome analysis revealed that 24 proteins were differentially expressed in tumor …
-
A Comparison of Cultured Human Dermal Fibroblasts Derived from Terminal and Vellus Hair Bearing Skin. Differences in the expression of inhibitors of apoptosis proteins, oestrogen receptors, and responses to oestradiol under normal and wound induced conditions
… in mRNA expression of the oestrogen receptors (GPR30, ERα and ERβ) were compared between the two cell types. IAP protein expression was generally found higher during mid anagen of the hair cycle in murine skin and hair follicles. Overall, expression was slightly higher in human terminal hair …
-
G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
<p>G-protein-coupled estrogen receptor 1 (GPER) is a G-protein-coupled receptor that induces non-genomic signaling in response to some nuclear estrogen receptor ligands. To date, the distribution and functional characterization of GPER within vertebrate organs have been restricted to juvenile and …