Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"GPR17"”.
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DEVELOPMENT OF NEW OLIGODENDROCYTE-BASED MODELS TO IDENTIFY PHARMACOLOGICAL AGENTS WITH REMYELINATING ACTIVITY
… cell membrane the G protein-coupled receptor 17 (GPR17). This expression is essential for their correct maturation; however, it needs to be downregulated to allow proper OL maturation. Accumulation of GPR17-positive cells has been observed in various neurodegenerative disease models, including …
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DISEASE-MODIFYING APPROACHES TO MULTIPLE SCLEROSIS: DESIGN AND SYNTHESIS OF NOVEL POTENTIAL THERAPEUTIC AGENTS
… compound PDMP. 2. Enhancing Remyelination via GPR17 modulation GPR17 is a G protein-coupled receptor expressed in a stage dependent manner during the maturation of the Oligodendrocyte Progenitor Cells (OPCs) and plays a key role in remyelination. Thus, we focused on the modulation of the …
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Postnatal specialization of astrocyte regional heterogeneity in the mammalian brain and improved tools for studying glia
… describe the generation and characterization of Gpr17-Cre, a novel Cre recombinase driver line sensitive and specific for the oligodendrocyte lineage and a subset of astrocytes in the central nervous system.